False-Positive Results of SARS-CoV-2 RT-PCR in Oropharyngeal Swabs From Vaccinators

Article Otorhinolaryngology

Analysis of Factors Causing False-Negative Real-Time Polymerase Chain Reaction Results in Oropharyngeal and Nasopharyngeal Swabs of Patients With COVID-19

Akif Islek et al.

Summary: Factors such as ageusia, anosmia, early sampling, and proper swab collection can lead to more accurate RT-PCR results for COVID-19 cases. Conversely, factors like the profession of the clinician, nasal steroid use, and presence of epistaxis can increase the likelihood of false-negative results.

ENT-EAR NOSE & THROAT JOURNAL (2022)

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Article Immunology

False Coronavirus Disease 2019 Cases due to Contamination by Inactivated Virus Vaccine

Kelvin Kai-Wang To et al.

Summary: This study reports two cases where respiratory samples were contaminated with an inactivated SARS-CoV-2 vaccine strain, likely occurring at the vaccination center. Whole genome sequencing revealed adaptive deletions on the spike protein of the vaccine strain, but without observable changes in antigenicity.

CLINICAL INFECTIOUS DISEASES (2022)

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Letter Public, Environmental & Occupational Health

False Positive Results With SARS-CoV-2 RT-PCR Tests and How to Evaluate a RT-PCR-Positive Test for the Possibility of a False Positive Result

Glenn D. Braunstein et al.

JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE (2021)

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Article Medicine, General & Internal

False-negative RT-PCR for COVID-19 and a diagnostic risk score: a retrospective cohort study among patients admitted to hospital

Ankur Gupta-Wright et al.

Summary: A retrospective cohort study was conducted on patients admitted to two hospitals within an acute NHS Trust in London, UK, between March 2 and May 3, 2020, to describe the characteristics of COVID-19 patients with false-negative SARS-CoV-2 RT-PCR results. The study found that RT-PCR-negative COVID-19 is common and associated with lower mortality despite similar presentation. Additionally, a diagnostic risk score was developed and internally validated to potentially help triage patients requiring admission.

BMJ OPEN (2021)

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Article Genetics & Heredity

Molecular epidemiology of SARS-CoV-2 isolated from COVID-19 family clusters

Gunadi et al.

Summary: This study is the first comprehensive report associating the full-genome sequences of SARS-CoV-2 with epidemiological data within family clusters. Phylogenetic analysis revealed that the viruses from family cluster-1 formed a monophyletic group, while viruses from family cluster-2 formed a polyphyletic group, indicating potential different sources of infection. The study also highlights how similar spike protein mutations among family members can lead to diverse disease outcomes.

BMC MEDICAL GENOMICS (2021)

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Article Otorhinolaryngology