期刊
METABOLITES
卷 12, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/metabo12080717
关键词
GC-TOF/MS; volar skin; non-volar skin; metabolomic analysis
资金
- National Research Foundation of Korea (NRF) [2020R1G1A100826811]
- National Research Foundation of Korea - Korean government (Ministry of Science and ICT) [2020R1C1C1005206]
- National Research Foundation of Korea [2020R1C1C1005206] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Skin has heterogenous identities on different body sites. The study used metabolomics analysis to investigate the metabolic differences between volar and non-volar skin in mice. It identified various metabolites associated with amino acid metabolism, sugar metabolism, and nucleotide metabolism. These findings provide valuable information for understanding the metabolic differences between volar and non-volar skin.
Skin has heterogenous identities on different body sites despite similar cellular compositions. There are two types of skin, volar (palmoplantar) and non-volar (dorsal), which are characterized by epidermal thickness, pigmentation, and presence of hair follicles. However, the mechanisms underlying the development of these different skin types remain unclear. To investigate these, we profiled the cellular metabolites of volar and non-volar skin in mice using gas chromatography-time-of-flight/mass spectrometry (GC-TOF/MS), and further assessed the metabolic differences between them. In total, 96 metabolites from both volar and non-volar skin of mice were identified using the BinBase database system. Metabolomics analysis revealed important differences associated with amino acid metabolism (phenylalanine, tyrosine, and tryptophan biosynthesis; aspartate and glutamate metabolism), sugar metabolism (pentose phosphate pathway), and nucleotide metabolism (pyrimidine metabolism) in volar skin. Fifty metabolites were identified as potential biomarkers differentiating the physiological characteristics of these skin types. Of these, nine were highly increased whereas 41 were significantly decreased in volar skin compared with those in non-volar skin. Overall, these results provide valuable information for understanding the metabolic differences between volar and non-volar skin.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据