4.6 Article

Severe COVID-19 Is Characterised by Perturbations in Plasma Amines Correlated with Immune Response Markers, and Linked to Inflammation and Oxidative Stress

期刊

METABOLITES
卷 12, 期 7, 页码 -

出版社

MDPI
DOI: 10.3390/metabo12070618

关键词

SARS-CoV-2; COVID-19; amino acid; amine; metabolomics; cytokine; inflammation; oxidative stress

资金

  1. NWA project 'Measuring and detection of health'
  2. NWO [184.034.019]
  3. Netherlands X-omics Initiative

向作者/读者索取更多资源

This article is significant in characterizing the biochemical response of COVID-19 patients and identifying therapeutic targets. Through LC-MS platform analysis of plasma samples, the study found certain amino acids and derivatives associated with inflammatory responses, contributing to understanding the metabolic status of severe cases.
The COVID-19 pandemic raised a need to characterise the biochemical response to SARS-CoV-2 infection and find biological markers to identify therapeutic targets. In support of these aims, we applied a range of LC-MS platforms to analyse over 100 plasma samples from patients with varying COVID-19 severity and with detailed clinical information on inflammatory responses (>30 immune markers). The first publication in a series reports the results of quantitative LC-MS/MS profiling of 56 amino acids and derivatives. A comparison between samples taken from ICU and ward patients revealed a notable increase in ten post-translationally modified amino acids that correlated with markers indicative of an excessive immune response: TNF-alpha, neutrophils, markers for macrophage, and leukocyte activation. Severe patients also had increased kynurenine, positively correlated with CRP and cytokines that induce its production. ICU and ward patients with high IL-6 showed decreased levels of 22 immune-supporting and anti-oxidative amino acids and derivatives (e.g., glutathione, GABA). These negatively correlated with CRP and IL-6 and positively correlated with markers indicative of adaptive immune activation. Including corresponding alterations in convalescing ward patients, the overall metabolic picture of severe COVID-19 reflected enhanced metabolic demands to maintain cell proliferation and redox balance, alongside increased inflammation and oxidative stress.

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