4.6 Article

A Quantitative Systems Pharmacology Platform Reveals NAFLD Pathophysiological States and Targeting Strategies

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Editorial Material Gastroenterology & Hepatology

Why Do So Many Nonalcoholic Steatohepatitis Trials Fail?

Vlad Ratziu et al.

GASTROENTEROLOGY (2023)

Article Cell Biology

The Nuclear Receptor PXR in Chronic Liver Disease

Katia Sayaf et al.

Summary: PXR, a nuclear receptor involved in chronic liver diseases, plays a crucial role in liver damage progression, repair, and the neoplastic transition to hepatocellular carcinoma. By modulating the transcription of drug metabolizing enzymes and transporters, PXR is an important factor in chronic liver diseases. PXR and its modulation could be a promising pharmacological target for novel therapeutical approaches to these diseases.
Article Multidisciplinary Sciences

A network-based computational and experimental framework for repurposing compounds toward the treatment of non-alcoholic fatty liver disease

Danae Stella Zareifi et al.

Summary: This study introduces a drug repositioning approach that effectively identifies therapeutic compounds for non-alcoholic fatty liver disease. The approach combines genomic data and compound-treated cell lines to screen and validate potential drugs, resulting in the identification of six compounds with similar efficacy to known antisteatogenic drugs.

ISCIENCE (2022)

Article Chemistry, Multidisciplinary

Histone deacetylase inhibitor givinostat attenuates nonalcoholic steatohepatitis and liver fibrosis

He-ming Huang et al.

Summary: Givinostat demonstrated therapeutic potential in treating nonalcoholic steatohepatitis (NASH) by alleviating inflammation and attenuating hepatic fibrosis, as shown in both in vivo and in vitro studies.

ACTA PHARMACOLOGICA SINICA (2022)

Article Gastroenterology & Hepatology

Effects of Statin Use on the Development and Progression of Nonalcoholic Fatty Liver Disease: A Nationwide Nested Case-Control Study

Jung Il Lee et al.

Summary: The study found that the use of statins can reduce the risk of NAFLD development and liver fibrosis.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2021)

Review Gastroenterology & Hepatology

Human biomimetic liver microphysiology systems in drug development and precision medicine

Albert Gough et al.

Summary: Microphysiology systems (MPS) are miniature functional units composed of multiple cell types that mimic human organ structure and function, providing valuable insights into disease mechanisms, treatment response, and serving as important tools in precision medicine.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2021)

Article Pharmacology & Pharmacy

Analysis of reproducibility and robustness of a human microfluidic four-cell liver acinus microphysiology system (LAMPS)

Courtney Sakolish et al.

Summary: The human microfluidic liver acinus microphysiology system (LAMPS) was evaluated for drug pharmacokinetics and toxicology, showing robustness and reproducibility when seeded with primary human hepatocytes or iPSC-derived hepatocytes, and demonstrating more physiologically and clinically relevant effects compared to 2D cultures.

TOXICOLOGY (2021)

Article Medicine, Research & Experimental

Echinatin effectively protects against NLRP3 inflammasome driven diseases by targeting HSP90

Guang Xu et al.

Summary: This study identified echinatin, a component of traditional herbal medicine licorice, as a potentially novel inhibitor of NLRP3 inflammasome activation in both in vitro and in vivo models. Echinatin was shown to exert inhibitory effects through its interaction with heat-shock protein 90 (HSP90), disrupting the formation of the HSP90-NLRP3 complex. The administration of echinatin demonstrated significant suppression of NLRP3 inflammasome activation and amelioration of inflammatory conditions in mouse models, suggesting its potential as a therapeutic approach for NLRP3-driven diseases.

JCI INSIGHT (2021)

Review Biochemistry & Molecular Biology

Mechanisms and disease consequences of nonalcoholic fatty liver disease

Rohit Loomba et al.

Summary: NAFLD and NASH are leading chronic liver diseases worldwide, causing progressive liver injury that can lead to cirrhosis and hepatocellular carcinoma. These diseases are associated with hepatic glucose and lipid metabolism, and are influenced by genetic, epigenetic, and environmental factors.
Review Medicine, Research & Experimental

Quantifying the progression of non-alcoholic fatty liver disease in human biomimetic liver microphysiology systems with fluorescent protein biosensors

Manush Saydmohammed et al.

Summary: Metabolic syndrome and non-alcoholic fatty liver disease (NAFLD) are closely related, with the term metabolic dysfunction-associated fatty liver disease (MAFLD) being proposed to cover the heterogeneity in NAFLD patients. There have been advancements in developing human microphysiology system disease models of NAFLD/MAFLD for monitoring disease progression and implementing quantitative systems pharmacology to repurpose drugs and guide the development of novel therapeutics.

EXPERIMENTAL BIOLOGY AND MEDICINE (2021)

Article Multidisciplinary Sciences

A network-based approach reveals the dysregulated transcriptional regulation in non-alcoholic liver disease

Hong Yang et al.

Summary: Researchers conducted network analysis and integrative systems analysis to reveal key transcriptional regulators and biological processes involved in the progression of NAFLD, enhancing the understanding of the disease mechanism.

ISCIENCE (2021)

Editorial Material Gastroenterology & Hepatology

Redefining non-alcoholic fatty liver disease: what's in a name?

[Anonymous]

LANCET GASTROENTEROLOGY & HEPATOLOGY (2020)

Article Multidisciplinary Sciences

Characterization of the immune cell landscape of patients with NAFLD

Tom Diedrich et al.

PLOS ONE (2020)

Article Multidisciplinary Sciences

Effect of a ketogenic diet on hepatic steatosis and hepatic mitochondrial metabolism in nonalcoholic fatty liver disease

Panu K. Luukkonen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Gastroenterology & Hepatology

Obeticholic acid for the treatment of nonalcoholic steatohepatitis

Raj A. Shah et al.

EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY (2020)

Article Gastroenterology & Hepatology

A Microphysiological System for Studying Nonalcoholic Steatohepatitis

Tomasz Kostrzewski et al.

HEPATOLOGY COMMUNICATIONS (2020)

Article Biochemical Research Methods

Applications of the microphysiology systems database for experimental ADME-Tox and disease models

Mark Schurdak et al.

LAB ON A CHIP (2020)

Review Biochemistry & Molecular Biology

Recent Insight into the Role of Fibrosis in Nonalcoholic Steatohepatitis-Related Hepatocellular Carcinoma

Antonio Sircana et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Gastroenterology & Hepatology

Past, present and future perspectives in nonalcoholic fatty liver disease

Arun J. Sanyal

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2019)

Review Gastroenterology & Hepatology

From NASH to HCC: current concepts and future challenges

Quentin M. Anstee et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2019)

Review Cell Biology

The Many Roles of Cell Adhesion Molecules in Hepatic Fibrosis

Edith Hintermann et al.

Review Medicine, General & Internal

Overview of organic anion transporters and organic anion transporter polypeptides and their roles in the liver

Ting-Ting Li et al.

WORLD JOURNAL OF CLINICAL CASES (2019)

Article Biochemistry & Molecular Biology

Gene expression profile-based drug screen identifies SAHA as a novel treatment for NAFLD

Zhujun Cheng et al.

MOLECULAR OMICS (2019)

Article Biochemistry & Molecular Biology

Ensembl 2018

Daniel R. Zerbino et al.

NUCLEIC ACIDS RESEARCH (2018)

Article Biochemistry & Molecular Biology

DrugBank 5.0: a major update to the DrugBank database for 2018

David S. Wishart et al.

NUCLEIC ACIDS RESEARCH (2018)

Article Gastroenterology & Hepatology

Clinical and Economic Burden of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis

Zobair M. Younossi et al.

CLINICS IN LIVER DISEASE (2018)

Letter Gastroenterology & Hepatology

Nonalcoholic Fatty Liver Disease: Is It Time for Combination Treatment and a Diabetes-Like Approach?

Stergios A. Polyzos et al.

HEPATOLOGY (2018)

Article Pharmacology & Pharmacy

Histone deacetylase inhibition attenuates hepatic steatosis in rats with experimental Cushing's syndrome

Mina Kim et al.

KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY (2018)

Review Biochemistry & Molecular Biology

Mechanisms of NAFLD development and therapeutic strategies

Scott L. Friedman et al.

NATURE MEDICINE (2018)

Review Gastroenterology & Hepatology

Systems biology in hepatology: approaches and applications

Adil Mardinoglu et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2018)

Review Pharmacology & Pharmacy

The Role of Statins in the Management of Nonalcoholic Fatty Liver Disease

Michael Doumas et al.

CURRENT PHARMACEUTICAL DESIGN (2018)

Article Cell Biology

Hepatocyte Notch activation induces liver fibrosis in nonalcoholic steatohepatitis

Changyu Zhu et al.

SCIENCE TRANSLATIONAL MEDICINE (2018)

Article Endocrinology & Metabolism

Transcriptomic Profiling of Obesity-Related Nonalcoholic Steatohepatitis Reveals a Core Set of Fibrosis-Specific Genes

Glenn S. Gerhard et al.

JOURNAL OF THE ENDOCRINE SOCIETY (2018)

Article Biochemistry & Molecular Biology

KEGG: new perspectives on genomes, pathways, diseases and drugs

Minoru Kanehisa et al.

NUCLEIC ACIDS RESEARCH (2017)

Article Medicine, Research & Experimental

Control of oxygen tension recapitulates zone-specific functions in human liver microphysiology systems

Felipe T. Lee-Montiel et al.

EXPERIMENTAL BIOLOGY AND MEDICINE (2017)

Review Gastroenterology & Hepatology

Using Big Data to Discover Diagnostics and Therapeutics for Gastrointestinal and Liver Diseases

Benjamin Wooden et al.

GASTROENTEROLOGY (2017)

Article Pharmacology & Pharmacy

PXR: More Than Just a Master Xenobiotic Receptor

Peter O. Oladimeji et al.

MOLECULAR PHARMACOLOGY (2017)

Article Multidisciplinary Sciences

Focal Adhesion Kinase Regulates Hepatic Stellate Cell Activation and Liver Fibrosis

Xue-Ke Zhao et al.

SCIENTIFIC REPORTS (2017)

Article Medicine, General & Internal

Thiazolidinediones and Advanced Liver Fibrosis in Nonalcoholic Steatohepatitis A Meta-analysis

Giovanni Musso et al.

JAMA INTERNAL MEDICINE (2017)

Article Biochemistry & Molecular Biology

A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles

Aravind Subramanian et al.

Article Medicine, Research & Experimental

A human liver microphysiology platform for investigating physiology, drug safety, and disease models

Lawrence A. Vernetti et al.

EXPERIMENTAL BIOLOGY AND MEDICINE (2016)

Review Pathology

Nonalcoholic Fatty Liver Disease: Pathogenesis and Disease Spectrum

Timothy Hardy et al.

ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 11 (2016)

Article Biochemistry & Molecular Biology

Nuclear receptors and nonalcoholic fatty liver diseases

Matthew C. Cave et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS (2016)

Article Biotechnology & Applied Microbiology

Near-optimal probabilistic RNA-seq quantification

Nicolas L. Bray et al.

NATURE BIOTECHNOLOGY (2016)

Article Multidisciplinary Sciences

Network-based in silico drug efficacy screening

Emre Guney et al.

NATURE COMMUNICATIONS (2016)

Article Biochemistry & Molecular Biology

Treatment of Obesity with Celastrol

Junli Liu et al.

Article Endocrinology & Metabolism

High Prevalence of Nonalcoholic Fatty Liver Disease in Patients With Type 2 Diabetes Mellitus and Normal Plasma Aminotransferase Levels

Paola Portillo-Sanchez et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2015)

Article Biochemistry & Molecular Biology

limma powers differential expression analyses for RNA-sequencing and microarray studies

Matthew E. Ritchie et al.

NUCLEIC ACIDS RESEARCH (2015)

Article Pharmacology & Pharmacy

A new histone deacetylase inhibitor improves liver fibrosis in BDL rats through suppression of hepatic stellate cells

Ki Cheong Park et al.

BRITISH JOURNAL OF PHARMACOLOGY (2014)

Article Biotechnology & Applied Microbiology

voom: precision weights unlock linear model analysis tools for RNA-seq read counts

Charity W. Law et al.

GENOME BIOLOGY (2014)

Article Biochemical Research Methods

GSVA: gene set variation analysis for microarray and RNA-Seq data

Sonja Haenzelmann et al.

BMC BIOINFORMATICS (2013)

Article Gastroenterology & Hepatology

Relationship Between Methylome and Transcriptome in Patients With Nonalcoholic Fatty Liver Disease

Susan K. Murphy et al.

GASTROENTEROLOGY (2013)

Article Genetics & Heredity

Molecular Interactions between NAFLD and Xenobiotic Metabolism

Adviti Naik et al.

Frontiers in Genetics (2013)

Article Biochemical Research Methods

The sva package for removing batch effects and other unwanted variation in high-throughput experiments

Jeffrey T. Leek et al.

BIOINFORMATICS (2012)

Article Gastroenterology & Hepatology

Macrophages: Central regulators of hepatic fibrogenesis and fibrosis resolution

Prakash Ramachandran et al.

JOURNAL OF HEPATOLOGY (2012)

Article Biochemical Research Methods

Molecular signatures database (MSigDB) 3.0

Arthur Liberzon et al.

BIOINFORMATICS (2011)

Article Computer Science, Interdisciplinary Applications

Regularization Paths for Generalized Linear Models via Coordinate Descent

Jerome Friedman et al.

JOURNAL OF STATISTICAL SOFTWARE (2010)

Article Medicine, General & Internal

Oxandrolone enhances hepatic ketogenesis in adult men

Gloria Lena Vega et al.

JOURNAL OF INVESTIGATIVE MEDICINE (2008)

Article Computer Science, Interdisciplinary Applications

Cluster-wise assessment of cluster stability

Christian Hennig

COMPUTATIONAL STATISTICS & DATA ANALYSIS (2007)

Article Genetics & Heredity

Capturing heterogeneity in gene expression studies by surrogate variable analysis

Jeffrey T. Leek et al.

PLOS GENETICS (2007)

Article Gastroenterology & Hepatology

Limited therapeutic efficacy of pioglitazone on progression of hepatic fibrosis in rats

I. A. Leclercq et al.

Article Multidisciplinary Sciences

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

A Subramanian et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Biochemistry & Molecular Biology

KEGG: Kyoto Encyclopedia of Genes and Genomes

M Kanehisa et al.

NUCLEIC ACIDS RESEARCH (2000)