期刊
METABOLITES
卷 12, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/metabo12070634
关键词
rheumatoid arthritis; autoimmune disease; inflammation
资金
- Russian Science Foundation [22-15-00273]
This article discusses the connection between metabolism and inflammation in rheumatoid arthritis, exploring the changes in metabolic processes and their immunomodulatory effects, as well as the metabolic features of synovial membrane cells during inflammation and potential targets for the therapy of rheumatoid arthritis.
Rheumatoid arthritis (RA) is a progressive autoimmune disease that affects the joints. It has been proven that, with the development of RA, there are changes in the metabolism of cells located in the focus of inflammation. In this article, we describe the connection between metabolism and inflammation in the context of rheumatoid arthritis. We consider in detail the changes in metabolic processes and their subsequent immunomodulatory effects. In particular, we consider how changes in mitochondrial functioning lead to the modulation of metabolism in rheumatoid arthritis. We also describe the main features of the metabolism in cells present in the synovial membrane during inflammation, and we discuss possible targets for the therapy of rheumatoid arthritis.
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