期刊
PATHOGENS
卷 11, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/pathogens11080863
关键词
LC3-associated phagocytosis; bacterial infection; phagocyte; immune evasion
类别
资金
- National Natural Science Foundation of China [81800012, 31560271]
- Science and Technology Project of Yunnan Province [202201AS070060]
- Foundation for High-Level Talents in Health and Health Technical of Yunnan [H-2018061]
- Joint Special Project of Yunnan Science and Technology Department and Kunming Medical University [202201AY070001-015]
- Foundation for High-Level Scientific and Technological Talents Selection Special Project of Yunnan [202105AC160025]
LC3-associated phagocytosis (LAP) is a noncanonical autophagy process that plays an important role in host defense against bacterial infection. This review summarizes the mechanism of LAP in resistance to bacterial infection and the strategies bacteria use to evade LAP.
LC3-associated phagocytosis (LAP) is a noncanonical autophagy process reported in recent years and is one of the effective mechanisms of host defense against bacterial infection. During LAP, bacteria are recognized by pattern recognition receptors (PRRs), enter the body, and then recruit LC3 onto a single-membrane phagosome to form a LAPosome. LC3 conjugation can promote the fusion of the LAPosomes with lysosomes, resulting in their maturation into phagolysosomes, which can effectively kill the identified pathogens. However, to survive in host cells, bacteria have also evolved strategies to evade killing by LAP. In this review, we summarized the mechanism of LAP in resistance to bacterial infection and the ways in which bacteria escape LAP. We aim to provide new clues for developing novel therapeutic strategies for bacterial infectious diseases.
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