期刊
PATHOGENS
卷 11, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/pathogens11070731
关键词
norovirus; B-cell epitope; surrogate model; cat
类别
资金
- JSPS KAKENHI [19K06407]
This study analyzed the B-cell linear epitope in the P domain of feline norovirus (FNoV) and found that elevated levels of antibodies against this epitope can improve viral shedding and clinical symptoms in FNoV-infected cats. These findings provide important insights into NoV infections in both humans and cats.
Norovirus (NoV) infection remains a major public health concern worldwide. Appropriate animal models are essential for the development of effective NoV vaccines. We previously established the feline NoV (FNoV)-cat model as a surrogate animal model for human NoV infection. In the present study, we analyzed the B-cell linear epitope in the P domain of FNoV to confirm the basic immunological features of the FNoV-cat model. B-cell linear epitopes were present in the P2 subdomain. We compared antibody levels to peptides containing the B-cell linear epitope (P-10) in three FNoV-infected cats with time-course changes in viral load and symptom scoring. After FNoV infection, viral shedding and clinical symptoms were shown to improve by elevated levels of antibodies against P-10 in the plasma. This report provides important information for understanding NoV infections in humans and cats.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据