Helicobacter pylori CagA Protein Regulating the Biological Characteristics of Gastric Cancer through the miR-155-5p/SMAD2/SP1 axis

Article Biochemistry & Molecular Biology

miRTarBase update 2022: an informative resource for experimentally validated miRNA-target interactions

Hsi-Yuan Huang et al.

Summary: miRTarBase is a large biological database that provides experimentally verified miRNA-target interactions, making it one of the most research-friendly MTI databases with comprehensive and experimentally verified annotations.

NUCLEIC ACIDS RESEARCH (2022)

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Article Oncology

LncRNA PCAT19 induced by SP1 and acted as oncogene in gastric cancer competitively binding to miR429 and upregulating DHX9

Lei Xiao et al.

Summary: The long non-coding RNA PCAT19 is upregulated in gastric cancer and is associated with tumor size, lymph node metastasis, and pathological stage. It functions as an oncogene by competitively binding to miR-429 and upregulating DHX9, promoting the proliferation and invasion of gastric cancer cells.

JOURNAL OF CANCER (2022)

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Article Biochemistry & Molecular Biology

KLF8 is activated by TGF-β1 via Smad2 and contributes to ovarian cancer progression

Aparna Cherukunnath et al.

Summary: KLF8 is overexpressed in ovarian cancer and promotes cancer progression. TGF-beta 1 activates KLF8 expression through the Smad2 pathway and regulates epithelial-mesenchymal transition (EMT), contributing to OC progression.

JOURNAL OF CELLULAR BIOCHEMISTRY (2022)

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Article Cell Biology

TRIM22 inhibits the proliferation of gastric cancer cells through the Smad2 protein

Zhuqing Zhou et al.

Summary: The study found that TRIM22 plays a crucial role in gastric cancer development and may inhibit the proliferation of gastric cancer cells through Smad2.

CELL DEATH DISCOVERY (2021)

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Review Biochemistry & Molecular Biology

Tumor-Progressive Mechanisms Mediating miRNA-Protein Interaction

Hiroaki Konishi et al.

Summary: miRNAs are small RNAs that fine-tune cellular protein expression and control tissue development, cell growth, and apoptosis. Aberrant regulation of miRNAs is involved in various diseases including cancer, and changes in miRNA expression in cancer tissues are correlated with cancer prognosis. They can be used as therapeutic targets and biomarkers for cancer treatment.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Cell Biology

Helicobacter pylori Virulence Factors-Mechanisms of Bacterial Pathogenicity in the Gastric Microenvironment

Jacek Baj et al.

Summary: Gastric cancer is a prevalent malignancy worldwide and ranks as the fourth leading cause of cancer-related deaths. The pathogenesis of gastric cancer involves the interaction between genetic and environmental factors, with Helicobacter pylori infection playing a major role. Understanding the mechanisms of H. pylori pathogenicity is crucial for developing eradication strategies to prevent carcinogenesis.

CELLS (2021)

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Article Cell Biology

circRNA_0005529 facilitates growth and metastasis of gastric cancer via regulating miR-527/Sp1 axis

Xing Zhang et al.

Summary: The study revealed that circ_0005529 was upregulated in gastric cancer, promoting cell proliferation and migration by reducing miR-527 expression and affecting Sp1 regulation. This circ_0005529/miR-527/Sp1 axis shows potential as a novel therapeutic target for GC diagnosis and treatment, as demonstrated in mouse models.

BMC MOLECULAR AND CELL BIOLOGY (2021)

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Article Oncology

CircTP63 promotes hepatocellular carcinoma progression by sponging miR-155-5p and upregulating ZBTB18

Jiantao Wang et al.

Summary: The study showed that circTP63 is significantly upregulated in HCC tissues and cell lines, and its high expression is associated with advanced tumor stages, lymph node metastasis, and poor prognosis in HCC patients. Mechanistically, circTP63 acts as a sponge for miR-155-5p to regulate ZBTB18 expression, which is negatively correlated with the survival rate of HCC patients, highlighting a critical regulatory network in HCC progression.

CANCER CELL INTERNATIONAL (2021)

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Article Immunology

Helicobacter pylori CagA Interacts with SHP-1 to Suppress the Immune Response by Targeting TRAF6 for K63-Linked Ubiquitination

Huan He et al.

Summary: The study found that CagA suppresses the expression of proinflammatory cytokines stimulated by H. pylori and inhibits downstream signal transduction, revealing a novel immune regulatory mechanism.

JOURNAL OF IMMUNOLOGY (2021)

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Article Microbiology

Helicobacter pylori CagA elicits BRCAness to induce genome instability that may underlie bacterial gastric carcinogenesis

Satoshi Imai et al.

Summary: Infection with CagA-producing H. pylori leads to gastric cancer development through disrupting DNA repair mechanisms, inhibiting apoptosis of damaged cells, and promoting somatic mutation. This hit-and-run mechanism creates a favorable environment for the initiation and progression of gastric carcinogenesis.

CELL HOST & MICROBE (2021)

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Article Oncology

Helicobacter pylori CagA Induces Cortactin Y-470 Phosphorylation-Dependent Gastric Epithelial Cell Scattering via Abl, Vav2 and Rac1 Activation

Nicole Tegtmeyer et al.

Summary: Helicobacter pylori manipulates host signaling in gastric disease development by hijacking cortactin phosphorylation and inducing cancer cell motility. The Abl inhibitor imatinib can effectively inhibit cortactin phosphorylation and may offer new opportunities for treatment of infections with this pathogen. The pathogen plays a role in human malignancies, including gastric adenocarcinoma, and subverts cortactin through a novel pathway involving tyrosine phosphorylation and activation of Rac1.

CANCERS (2021)

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Review Oncology

Molecular Mechanism ofHelicobacter pylori-Induced Gastric Cancer

Majid Alipour

Summary: This study aimed to investigate the role of Helicobacter pylori in the development of gastric cancer. It was found that H. pylori infection is a known risk factor for gastric cancer, and its virulence factors can trigger cell proliferation through activating cell signaling pathways, leading to cancer.

JOURNAL OF GASTROINTESTINAL CANCER (2021)

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Article Biotechnology & Applied Microbiology

MiR-155-5p promotes metastasis and epithelial-mesenchymal transition of renal cell carcinoma by targeting apoptosis-inducing factor

Qing-qing Lei et al.

Summary: miR-155-5p is significantly elevated in renal cancer tissues and cells, suppressing miR-155-5p can decrease tumor growth, migration, and invasion, while overexpression of miR-155-5p leads to opposite effects by targeting the apoptosis-inducing factor.

INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS (2021)

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Article Biochemistry & Molecular Biology