期刊
FRONTIERS IN MOLECULAR BIOSCIENCES
卷 9, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fmolb.2022.900533
关键词
allergen; pollen; sensitization; lipids; allergen-specific antibody; ligand-allergen interaction
资金
- Russian Science Foundation [20-45-05002]
- FWF Austrian Science Fund [4437]
- Russian Science Foundation [20-45-05002] Funding Source: Russian Science Foundation
Plant pollen is a major allergen causing allergic diseases such as allergic rhinitis and asthma. The interaction between allergens and molecular factors, as well as their interaction with lipids and other hydrophobic molecules, play important roles in pollen sensitization.
Plant pollen is one of the main sources of allergens causing allergic diseases such as allergic rhinitis and asthma. Several allergens in plant pollen are panallergens which are also present in other allergen sources. As a result, sensitized individuals may also experience food allergies. The mechanism of sensitization and development of allergic inflammation is a consequence of the interaction of allergens with a large number of molecular factors that often are acting in a complex with other compounds, for example low-molecular-mass ligands, which contribute to the induction a type 2-driven response of immune system. In this review, special attention is paid not only to properties of allergens but also to an important role of their interaction with lipids and other hydrophobic molecules in pollen sensitization. The reactions of epithelial cells lining the nasal and bronchial mucosa and of other immunocompetent cells will also be considered, in particular the mechanisms of the activation of B and T lymphocytes and the formation of allergen-specific antibody responses.
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