Effects of PCSK9 inhibitors on HDL cholesterol efflux and serum cholesterol loading capacity in familial hypercholesterolemia subjects: a multi-lipid-center real-world evaluation

Article Medicine, Research & Experimental

Beneficial effects of PCSK9 inhibition with alirocumab in familial hypercholesterolemia involve modulation of new immune players

Patrice Marques et al.

Summary: Inhibiting PCSK9 function can impact systemic inflammation and endothelial dysfunction by constraining leukocyte-endothelium interactions, enhancing T-regulatory cell activation, and reducing inflammatory response.

BIOMEDICINE & PHARMACOTHERAPY (2022)

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Review Biochemistry & Molecular Biology

Lipoprotein(a)-The Crossroads of Atherosclerosis, Atherothrombosis and Inflammation

Sabina Ugovsek et al.

Summary: Increased levels of lipoprotein(a) are associated with coronary artery disease, degenerative aortic stenosis, and heart failure. These levels are determined by genetic variations of the LPA gene encoding the apolipoprotein(a) component of lipoprotein(a). Lipoprotein(a) increases cardiovascular risk through various mechanisms.

BIOMOLECULES (2022)

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Article Medicine, General & Internal

Effect of a PCSK9 inhibitor and a statin on cholesterol efflux capacity: A limitation of current cholesterol-lowering treatments?

Qidi Ying et al.

Summary: The study found that evolocumab and atorvastatin can decrease the capacity of whole plasma to efflux cellular cholesterol in normolipidaemic men, which may be mainly due to a decrease in the availability of apoB-100-containing lipoproteins.

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2022)

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Article Cardiac & Cardiovascular Systems

PCSK9 and LRP5 in macrophage lipid internalization and inflammation

Lina Badimon et al.

Summary: The study demonstrates that LRP5 plays a crucial role in macrophage lipid uptake, and in the absence of both LRP5 and PCSK9, there is a significant reduction in CE accumulation, indicating a role for both proteins in lipid uptake. Additionally, LRP5 forms a complex with PCSK9 in lipid-loaded macrophages.

CARDIOVASCULAR RESEARCH (2021)

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Article Cardiac & Cardiovascular Systems

Effect of PCSK9 inhibitor on lipoprotein particles in patients with acute coronary syndromes

Tingting Li et al.

Summary: Evolocumab combination treatment for 8 weeks significantly improves plasma lipid profiles in ACS patients, and decreases the concentration of lipoprotein particles, potentially contributing to atherosclerosis pathogenesis.

BMC CARDIOVASCULAR DISORDERS (2021)

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Article Cardiac & Cardiovascular Systems

The effect of transgender hormonal treatment on high density lipoprotein cholesterol efflux capacity

Daan M. van Velzen et al.

Summary: Total HDL-CEC decreased during HT in trans women, with a specific reduction in ABCA1 CEC. This finding might contribute to a higher CVD risk.

ATHEROSCLEROSIS (2021)

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Review Cell Biology

High Density Lipoprotein Cholesterol Efflux Capacity and Atherosclerosis in Cardiovascular Disease: Pathophysiological Aspects and Pharmacological Perspectives

Maria Pia Adorni et al.

Summary: HDL cholesterol efflux capacity (CEC) has emerged as a better predictor of cardiovascular risk compared to plasma HDL-cholesterol levels, and is often impaired in various genetic and pathological conditions associated with high cardiovascular risk.

CELLS (2021)

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Article Endocrinology & Metabolism

Effect of PCSK9 inhibitors on pulse wave velocity and monocyte-to-HDL-cholesterol ratio in familial hypercholesterolemia subjects: results from a single-lipid-unit real-life setting

Roberto Scicali et al.

Summary: This study aimed to evaluate the impact of PCSK9-i therapy on inflammatory biomarkers, pulse wave velocity, and atherosclerosis damage in FH subjects. The results showed that PCSK9-i therapy significantly reduced LDL-C levels, neutrophil count, and MHR, while also decreasing PWV. Additionally, there was a significant association between an increase in PWV and an increase in LDL-C, neutrophil count, and MHR.

ACTA DIABETOLOGICA (2021)

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Review Biotechnology & Applied Microbiology

A Systematic Review and Meta-Analysis of Therapeutic Efficacy and Safety of Alirocumab and Evolocumab on Familial Hypercholesterolemia

Xiaoyue Ge et al.

Summary: PCSK9 monoclonal antibodies significantly decreased LDL-C and other lipid levels in the treatment of FH with satisfactory safety and tolerability.

BIOMED RESEARCH INTERNATIONAL (2021)

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Review Cardiac & Cardiovascular Systems

Cholesterol Efflux Capacity and Its Association With Adverse Cardiovascular Events: A Systematic Review and Meta-Analysis

Jane J. Lee et al.

Summary: The study found that higher cholesterol efflux capacity (CEC) was associated with lower adverse cardiovascular outcomes, with each standard deviation increase in CEC reducing the risk of adverse cardiovascular events. These findings suggest that CEC may be an important protective factor that could potentially be targeted for improving clinical outcomes.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2021)

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Review Cardiac & Cardiovascular Systems

High-density lipoproteins, reverse cholesterol transport and atherogenesis

Henry J. Pownall et al.

Summary: Plasma HDL-cholesterol levels are negatively correlated with the risk of ASCVD, but genetic approaches to increase HDL levels do not reduce this risk. The mechanism of reverse cholesterol transport involving FCh transfer between HDL and macrophages is still under debate in relation to ASCVD.

NATURE REVIEWS CARDIOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

HDL in the 21st Century A Multifunctional Roadmap for Future HDL Research

Anand Rohatgi et al.

Summary: Low high-density lipoprotein cholesterol (HDL-C) is associated with adverse lifestyle choices, cardiovascular diseases, inflammatory disorders, and other conditions. Therapeutic strategies targeting HDL-C levels have not been successful, and future focus should be on optimizing HDL function for better outcomes.

CIRCULATION (2021)

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Article Cardiac & Cardiovascular Systems

2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk The Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and European Atherosclerosis Society (EAS)

Francois Mach et al.

EUROPEAN HEART JOURNAL (2020)

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Review Biotechnology & Applied Microbiology

PCSK9 inhibitors and cardiovascular outcomes

Daniel Steffens et al.

EXPERT OPINION ON BIOLOGICAL THERAPY (2020)

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Article Cardiac & Cardiovascular Systems

Dysfunctional High-Density Lipoproteins Are Associated With a Greater Incidence of Acute Coronary Syndrome in a Population at High Cardiovascular Risk A Nested Case-Control Study

Maria Trinidad Soria-Florido et al.

CIRCULATION (2020)

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Review Pharmacology & Pharmacy

PCSK9 inhibitors for treating hypercholesterolemia

Andrea Pasta et al.

EXPERT OPINION ON PHARMACOTHERAPY (2020)

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Article Medicine, General & Internal

Anti-atherogenic Modification of Serum Lipoprotein Function in Patients with Rheumatoid Arthritis after Tocilizumab Treatment, a Pilot Study

Daniela Greco et al.

JOURNAL OF CLINICAL MEDICINE (2020)

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Review Peripheral Vascular Disease

An Update on the Role of PCSK9 in Atherosclerosis

Ece Yurtseven et al.

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS (2020)

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Article Pharmacology & Pharmacy

Treatment with PCSK9 inhibitors induces a more anti-atherogenic HDL lipid profile in patients at high cardiovascular risk

Cecile Ingueneau et al.

VASCULAR PHARMACOLOGY (2020)

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Article Biochemistry & Molecular Biology

Usefulness of apolipoprotein B-depleted serum in cholesterol efflux capacity assays using immobilized liposome-bound gel beads

Yuna Hoduchi et al.

BIOSCIENCE REPORTS (2019)

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Article Endocrinology & Metabolism

High-Density Lipoprotein Function Is Reduced in Patients Affected by Genetic or Idiopathic Hypogonadism

Maria Pia Adorni et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2019)

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Review Geriatrics & Gerontology

Proprotein Convertase Subtilisin/Kexin Type 9, Brain Cholesterol Homeostasis and Potential Implication for Alzheimer's Disease

Maria Pia Adorni et al.

FRONTIERS IN AGING NEUROSCIENCE (2019)

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Article Cardiac & Cardiovascular Systems

Effect of the PCSK9 Inhibitor Evolocumab on Total Cardiovascular Events in Patients With Cardiovascular Disease: A Prespecified Analysis From the FOURIER Trial

Sabina A. Murphy et al.

JAMA CARDIOLOGY (2019)

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Article Cardiac & Cardiovascular Systems

Lipoprotein(a), PCSK9 Inhibition, and Cardiovascular Risk Insights From the FOURIER Trial

Michelle L. O'Donoghue et al.

CIRCULATION (2019)

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Review Pharmacology & Pharmacy

Clinical Pharmacokinetics and Pharmacodynamics of Evolocumab, a PCSK9 Inhibitor

Sreeneeranj Kasichayanula et al.

CLINICAL PHARMACOKINETICS (2018)

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Article Hematology

Lipoprotein Lipoprotein apheresis affects lipoprotein particle subclasses more efficiently compared to the PCSK9 inhibitor evolocumab, a pilot study

Knut Tore Lappegard et al.

TRANSFUSION AND APHERESIS SCIENCE (2018)

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Article Medicine, General & Internal

PCSK9 Inhibitor causes a decrease in the level of oxidatively modified low-density lipoproteins in patients with coronary artery diseases

V. Z. Lankin et al.

TERAPEVTICHESKII ARKHIV (2018)

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Editorial Material Pharmacology & Pharmacy

JCL roundtable: High-density lipoprotein function and reverse cholesterol transport

Marina Cuchel et al.

JOURNAL OF CLINICAL LIPIDOLOGY (2018)

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Article Biochemistry & Molecular Biology

Influence of HDL particles on cell-cholesterol efflux under various pathological conditions

Bela F. Asztalos et al.

JOURNAL OF LIPID RESEARCH (2017)

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Article Biochemistry & Molecular Biology

Plasma cholesterol homeostasis, HDL remodeling and function during the acute phase reaction

Francesca Zimetti et al.

JOURNAL OF LIPID RESEARCH (2017)

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Review Genetics & Heredity

Mechanisms of foam cell formation in atherosclerosis

Dimitry A. Chistiakov et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2017)

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Article Medicine, General & Internal

Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease

Marc S. Sabatine et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

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Article Cardiac & Cardiovascular Systems

Inhibitory effect of PCSK9 on Abca1 protein expression and cholesterol efflux in macrophages

Maria Pia Adorni et al.

ATHEROSCLEROSIS (2017)

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Article Peripheral Vascular Disease

Familial hypercholesterolemia: The Italian Atherosclerosis Society Network (LIPIGEN)

Maurizio Averna et al.

ATHEROSCLEROSIS SUPPLEMENTS (2017)

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Article Cardiac & Cardiovascular Systems

Cholesterol Efflux Capacity, High-Density Lipoprotein Particle Number, and Incident Cardiovascular Events An Analysis From the JUPITER Trial (Justification for the Use of Statins in Prevention: An Intervention Trial Evaluating Rosuvastatin)

Amit V. Khera et al.

CIRCULATION (2017)

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Article Hematology

Association Between Cholesterol Efflux Capacity and Atherosclerotic Cardiovascular Disease in Patients With Familial Hypercholesterolemia

Masatsune Ogura et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2016)

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Letter Medicine, General & Internal

HDL Cholesterol Efflux Capacity and Cardiovascular Events

Matthew N. Peters et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

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Article Rheumatology

Newly Identified Antiatherosclerotic Activity of Methotrexate and Adalimumab Complementary Effects on Lipoprotein Function and Macrophage Cholesterol Metabolism

Nicoletta Ronda et al.

ARTHRITIS & RHEUMATOLOGY (2015)

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Article Endocrinology & Metabolism

Association of HDL cholesterol efflux capacity with incident coronary heart disease events: a prospective case-control study

Danish Saleheen et al.

LANCET DIABETES & ENDOCRINOLOGY (2015)

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Article Rheumatology

Impaired serum cholesterol efflux capacity in rheumatoid arthritis and systemic lupus erythematosus

Nicoletta Ronda et al.

ANNALS OF THE RHEUMATIC DISEASES (2014)

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Article Hematology

Importance of Evaluating Cell Cholesterol Influx With Efflux in Determining the Impact of Human Serum on Cholesterol Metabolism and Atherosclerosis

Ginny L. Weibel et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2014)

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Article Medicine, General & Internal

HDL Cholesterol Efflux Capacity and Incident Cardiovascular Events

Anand Rohatgi et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

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Review Medical Laboratory Technology

Foam cells in atherosclerosis

Xiao-Hua Yu et al.

CLINICA CHIMICA ACTA (2013)

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Article Pharmacology & Pharmacy

Cholesterol efflux mediators in homozygous familial hypercholesterolemia patients on low-density lipoprotein apheresis

Marit S. Nenseter et al.

JOURNAL OF CLINICAL LIPIDOLOGY (2013)

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Review Biochemistry & Molecular Biology

The role of cholesterol efflux in mechanisms of endothelial protection by HDL

Hamish C. Prosser et al.

CURRENT OPINION IN LIPIDOLOGY (2012)

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Article Biochemistry & Molecular Biology

Cellular cholesterol efflux and cholesterol loading capacity of serum: effects of LDL-apheresis

M. P. Adorni et al.

JOURNAL OF LIPID RESEARCH (2012)

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Article Medicine, General & Internal

Effect of a monoclonal antibody to PCSK9, REGN727/SAR236553, to reduce low-density lipoprotein cholesterol in patients with heterozygous familial hypercholesterolaemia on stable statin dose with or without ezetimibe therapy: a phase 2 randomised controlled trial

Evan A. Stein et al.

LANCET (2012)

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Article Biochemistry & Molecular Biology

Effects of acceptor composition and mechanism of ABCG1-mediated cellular free cholesterol efflux

Sandhya Sankaranarayanan et al.

JOURNAL OF LIPID RESEARCH (2009)

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Article Biochemistry & Molecular Biology

Measurement of cholesterol bidirectional flux between cells and lipoproteins

F Zimetti et al.

JOURNAL OF LIPID RESEARCH (2006)

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Article Biochemistry & Molecular Biology

Impaired ATP-binding cassette transporter Al-mediated sterol efflux from oxidized LDL-loaded macrophages

E Favari et al.

FEBS LETTERS (2005)

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Article Biochemistry & Molecular Biology

Differential effects of HDL subpopulations on cellular ABCA1- and SR-BI-mediated cholesterol efflux

BF Asztalos et al.

JOURNAL OF LIPID RESEARCH (2005)

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Effects of PCSK9 inhibitors on HDL cholesterol efflux and serum cholesterol loading capacity in familial hypercholesterolemia subjects: a multi-lipid-center real-world evaluation

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