期刊
FRONTIERS IN MOLECULAR BIOSCIENCES
卷 9, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fmolb.2022.945808
关键词
antibody-antigen complex; epitope analysis; paratope analysis; complementarity-determining region (CDR); structure analysis and characterization
Antibodies are a versatile tool in molecular biology and nanotechnology due to their ability to specifically recognize molecular antigens. The improvement of structural biology techniques and the emergence of new ones have led to an increase in resolved antibody-antigen structures, allowing for a comprehensive characterization of antibody-antigen interfaces.
Antibodies have become the Swiss Army tool for molecular biology and nanotechnology. Their outstanding ability to specifically recognise molecular antigens allows their use in many different applications from medicine to the industry. Moreover, the improvement of conventional structural biology techniques (e.g., X-ray, NMR) as well as the emergence of new ones (e.g., Cryo-EM), have permitted in the last years a notable increase of resolved antibody-antigen structures. This offers a unique opportunity to perform an exhaustive structural analysis of antibody-antigen interfaces by employing the large amount of data available nowadays. To leverage this factor, different geometric as well as chemical descriptors were evaluated to perform a comprehensive characterization.
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