☆ 4.6 Review

Nanoparticles in ocular applications and their potential toxicity

FRONTIERS IN MOLECULAR BIOSCIENCES (2022)

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Article Instruments & Instrumentation

Liposomal drug delivery system for anti-inflammatory treatment after cataract surgery: a phase I/II clinical trial

Chee Wai Wong et al.

Summary: The safety and efficacy of a single subconjunctival injection of liposomal prednisolone phosphate (LPP) for post-cataract surgery inflammation was evaluated in this study. It was found to be a safe and effective treatment, potentially replacing eyedrops as anti-inflammatory therapy following cataract surgery.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2022)

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Article Multidisciplinary Sciences

Comparison of cytotoxicity effects induced by four different types of nanoparticles in human corneal and conjunctival epithelial cells

Xiangzhe Li et al.

Summary: This study investigated the toxicity effects of different chemical components of particulate matter on the ocular surface. It was found that the cytotoxic effects of SiO2, CB, and ZnO nanoparticles depend on particle properties, cell type, exposure concentration, and time. TiO2 showed no toxicity. The toxicity was more severe in corneal epithelial cells compared to conjunctival epithelial cells. The toxicity was mediated by reactive oxygen species (ROS)-induced oxidative stress, leading to apoptosis and mitochondrial damage. SIRT1 may play a potential protective role in this process.

SCIENTIFIC REPORTS (2022)

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Review Environmental Sciences

Advanced human developmental toxicity and teratogenicity assessment using human organoid models

Minghui Li et al.

Summary: Significant progress has been made in toxicology, leading to advances in developmental toxicity assessment. Human organoid models, derived from hESCs and iPSCs, prove to be indispensable in accurately describing toxic effects and predicting in vivo responses. These models are valuable tools for drug discovery and safety assessment.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2022)

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Article Environmental Sciences

Evaluation of the influences of low dose polybrominated diphenyl ethers exposure on human early retinal development

Minghui Li et al.

Summary: This study utilizes human embryonic stem cell-derived retinal organoids (hESC-ROs) to assess the toxicity of polybrominated diphenyl ethers (PBDEs) on retinal development. The results show that low-level exposure to PBDEs leads to decreased retinal thickness and area, abnormal cell distributions, reduced cell proliferation, increased cell apoptosis, and abnormal differentiation. Transcriptomic and metabolomic analysis further reveal the impact of PBDEs on extracellular matrix organization and metabolism. Overall, this study enhances our understanding of the retinotoxicity of PBDEs during early human retinal development.

ENVIRONMENT INTERNATIONAL (2022)

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Review Biochemical Research Methods

Diverse biotechnological applications of multifunctional titanium dioxide nanoparticles: An up-to-date review

Rabia Javed et al.

Summary: Titanium dioxide nanoparticles (TiO2 NPs) are widely used metallic oxide nanoparticles. Doping can improve the properties of the nanoparticles and have significant effects in the field of biotechnology. The exponential growth of research on TiO2 NPs is due to their chemical stability, low toxicity, and multifaceted properties. They are extensively used in agriculture, environmental remediation, and nanomedicine.

IET NANOBIOTECHNOLOGY (2022)

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Review Chemistry, Multidisciplinary

Bibliometric and visualized analysis of ocular drug delivery from 2001 to 2020

Cheng Peng et al.

Summary: This study conducted a bibliometric analysis on ocular drug delivery research over the past decade to characterize international trends and emerging frontiers. The results showed a significant increase in publications and citations, with the United States, the University of Florida, and Chauhan, Anuj being the most productive and impactful entities. The study identified important subtopics such as micro/nano ocular drug delivery systems, treatment of inflammation and posterior diseases, and emerging frontiers in ocular drug delivery.

JOURNAL OF CONTROLLED RELEASE (2022)

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Review Ophthalmology

Fungal keratitis: A review of clinical presentations, treatment strategies and outcomes

Namrata Sharma et al.

Summary: Infectious keratitis, particularly fungal keratitis, is a significant cause of corneal blindness worldwide, especially in developing countries. It presents various challenges to physicians due to delayed presentation, limited availability of effective antifungal drugs, and a high recurrence rate. However, advancements in rapid diagnostic tools, molecular methods, and treatment approaches have improved our understanding and management of fungal keratitis.

OCULAR SURFACE (2022)

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Review Toxicology

Toxicity, preparation methods and applications of silver nanoparticles: an update

Anuj Choudhary et al.

Summary: This article summarizes the mechanisms and detection methods of genotoxicity, cytotoxicity, neurotoxicity, and reproductive toxicity of silver nanoparticles in in vitro and in vivo studies. The toxicity of silver nanoparticles mainly involves the disruption of the mitochondrial respiratory chain, leading to the generation of ROS and the stoppage of ATP synthesis, which further leads to a cascade of toxic events.

TOXICOLOGY MECHANISMS AND METHODS (2022)

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Article Biotechnology & Applied Microbiology

Graphene quantum dots rescue angiogenic retinopathy via blocking STAT3/Periostin/ERK signaling

Na Zhao et al.

Summary: The study found that Graphene Quantum Dots (GQDs) are biocompatible nanomaterials that can inhibit proliferation, migration, tube formation, and sprouting of human umbilical vein endothelial cells in a dose-dependent manner, and can inhibit pathological retinal neovascularization in an oxygen-induced retinopathy model. The data suggest that GQDs disrupt the periostin/ERK pathway and subsequent cell cycle regulation. This signaling pathway was confirmed in an OIR mouse model.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

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Review Immunology

Advancement of nanomedicines in chronic inflammatory disorders

Vikas Jogpal et al.

Summary: Chronic inflammatory diseases pose a threat to human health, and traditional medicine using natural products may offer therapeutic benefits. Nanoparticles, as a new drug delivery device, can enhance drug efficacy and bioavailability. Nanoparticles play an important role in the treatment of various inflammatory diseases.

INFLAMMOPHARMACOLOGY (2022)

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Review Pharmacology & Pharmacy

Nanocarrier Drug Delivery Systems: Characterization, Limitations, Future Perspectives and Implementation of Artificial Intelligence

Samar Zuhair Alshawwa et al.

Summary: There is an increasing demand for the development of nanocarriers that can target multiple diseases with a broad range of properties. Nanocarriers, due to their tiny size, large surface area, and feasible targetability, have optimized efficacy, decreased side effects, and improved stability compared to conventional drug dosage forms. Various types of nanocarriers have been synthesized for drug delivery, and characterization techniques have been proposed and used to predict the behavior of nanocarriers in vitro and in vivo. However, challenges in safety, regulation, and manufacturing hinder the translation of nanocarriers from the laboratory to the clinic.

PHARMACEUTICS (2022)

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Article Engineering, Biomedical

Production of human spinal-cord organoids recapitulating neural-tube morphogenesis

Ju-Hyun Lee et al.

Summary: A three-dimensional culture system and protocol for the production of human spinal-cord-like organoids have been developed, which recapitulate the morphogenesis of the early spinal cord and can be used for disease modeling and drug screening.

NATURE BIOMEDICAL ENGINEERING (2022)

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Article Environmental Sciences

Double-Sided Nano-ZnO: Superior Antibacterial Properties and Induced Hepatotoxicity in Zebrafish Embryos

Mingyue He et al.

Summary: Nano-ZnO exhibits excellent antibacterial properties but can cause hepatotoxicity leading to the development of fatty liver disease in zebrafish. Our study reveals that Nano-ZnO triggers oxidative and endoplasmic reticulum stress, promoting fatty acid synthesis and steatosis. Treatment with carbon dots alleviates the hepatotoxicity of Nano-ZnO.

TOXICS (2022)

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Review Medicine, Research & Experimental

Nanoparticulate Drug Delivery to the Retina

Qingqing Li et al.

Summary: Retinal diseases like age-related macular degeneration and diabetic retinopathy are major causes of blindness worldwide. Current treatment mainly relies on surgery and faces challenges in drug delivery to the retina. Nano drug delivery systems show promise but require a deep understanding of retinal pathology and eye physiology for successful translation to clinical use.

MOLECULAR PHARMACEUTICS (2021)

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Article Ophthalmology

Preparation and in vitro/in vivo evaluations of novel ocular micelle formulations of hesperetin with glycyrrhizin as a nanocarrier

Fan Zhang et al.

Summary: This study successfully developed an ophthalmic solution based on dipotassium glycyrrhizinate micelles, which can effectively improve the bioavailability and antioxidant activity of hesperetin. The ophthalmic solution has good tolerance and can significantly reduce symptoms of bacterial eye infections.

EXPERIMENTAL EYE RESEARCH (2021)

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Article Ophthalmology

Effects of Nonporous Silica Nanoparticles on Human Trabecular Meshwork Cells

Martha Kim et al.

Summary: Silica nanoparticles induce mild and dose-dependent cytotoxicity in human TM cells, while not compromising the mTOR pathway and tissue structure of the aqueous plexus.

JOURNAL OF GLAUCOMA (2021)

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Review Ophthalmology

Inflammation in Glaucoma: From the back to the front of the eye, and beyond

Christophe Baudouin et al.

Summary: The pathophysiology of glaucoma is complex and multifactorial, involving elevated intraocular pressure and impaired retinal blood flow as primary factors. Oxidative stress, cell senescence, mitochondrial dysfunction, excitotoxicity, and neuroinflammation play crucial roles in glaucoma progression. Inflammatory processes in various ocular structures from the posterior to the anterior segment are present in glaucoma, supporting the hypothesis of dysregulation towards a pro-inflammatory phenotype. Possible anti-inflammatory therapeutic approaches for glaucoma are also discussed.

PROGRESS IN RETINAL AND EYE RESEARCH (2021)

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Article Biochemistry & Molecular Biology

Involvement of TRPM2 Channel on Hypoxia-Induced Oxidative Injury, Inflammation, and Cell Death in Retinal Pigment Epithelial Cells: Modulator Action of Selenium Nanoparticles

Dilek Ozkaya et al.

Summary: The study investigated the role of TRPM2 channel in oxidative injury, inflammation, and apoptosis induced by HYPX in ARPE-19 cells, as well as the protective role of selenium nanoparticles in inhibiting TRPM2 channel against HYPX-induced oxidative injury and apoptosis.

BIOLOGICAL TRACE ELEMENT RESEARCH (2021)

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Article Pharmacology & Pharmacy

Liposomes as vehicles for topical ophthalmic drug delivery and ocular surface protection

Jose Javier Lopez-Cano et al.

Summary: The development of ophthalmic formulations using liposomes has been a popular topic in recent years. Understanding the physiological and anatomical structures of the eye is crucial for the design of effective liposomal formulations. Liposomes offer an effective, safe, and versatile strategy for the treatment of ocular diseases, with the potential for using specific biomaterials to enhance therapeutic properties.

EXPERT OPINION ON DRUG DELIVERY (2021)

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Article Biophysics

Hydroxypropyl methacrylamide-based copolymeric nanoparticles loaded with moxifloxacin as a mucoadhesive, cornea-penetrating nanomedicine eye drop with enhanced therapeutic benefits in bacterial keratitis

Sanjay Ch et al.

Summary: In this study, Mox-loaded copolymeric nanoparticles were prepared for the treatment of bacterial keratitis, showing excellent drug loading, mucoadhesion, and antimicrobial activity. The results demonstrate the safety and effectiveness of the drug solution in treating bacterial keratitis.

COLLOIDS AND SURFACES B-BIOINTERFACES (2021)

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Review Biochemistry & Molecular Biology

Safe Nanoparticles: Are We There Yet?

Wided Najahi-Missaoui et al.

Summary: The field of nanotechnology has rapidly grown over the past two decades, leading to the emergence of nanoparticles as promising tools in various applications. However, questions about the toxicity and safety of nanoparticles remain unanswered, despite efforts to understand them. Several approaches to minimize and prevent nanoparticle toxicity have been identified through research.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Engineering, Biomedical

Surface functionalized mesoporous silica nanoparticles for intravitreal application of tacrolimus

Mayara Rodrigues Brandao Paiva et al.

Summary: The study successfully incorporated tacrolimus into functionalized silica nanoparticles, which showed good biocompatibility in vitro and on chorioallantoic membrane (CAM) in vivo. Intravitreal injection of MSNAPTES TAC nanoparticles did not cause any adverse effects on rat eyes, suggesting its safety for ocular drug delivery.

JOURNAL OF BIOMATERIALS APPLICATIONS (2021)

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Review Pharmacology & Pharmacy

A review of nanocarrier-mediated drug delivery systems for posterior segment eye disease: challenges analysis and recent advances

Rui Wang et al.

Summary: Posterior segment eye diseases are a major cause of irreversible vision impairment and blindness, and the challenges in treating them lie in the physiological barriers and elimination mechanisms that exist in the eye. Nanocarriers, such as lipid nanoparticles and polymeric nanomicelles, have shown promise in enhancing ocular tissue permeability and controlled drug release for targeted therapy, but their clinical application as non-invasive ocular drops is still under development. Understanding the barriers and routes of ocular drug delivery is essential for the development of effective drug delivery systems for posterior segment diseases.

JOURNAL OF DRUG TARGETING (2021)

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Article Toxicology

Titanium dioxide nanoparticles impair the inner blood-retinal barrier and retinal electrophysiology through rapid ADAM17 activation and claudin-5 degradation

Yen-Ju Chan et al.

Summary: The exposure to TiO2 nanoparticles caused damage to endothelial cell function, leading to changes in retinal electrophysiology as observed in vitro and in vivo experiments, highlighting the potential risks of ocular contact with TiO2-NPs.

PARTICLE AND FIBRE TOXICOLOGY (2021)

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Review Developmental Biology

Research on nanoparticles in human perfused placenta: State of the art and perspectives

Leonie Aengenheister et al.

Summary: Increasing human exposure to nanoparticles raises concerns for public health, especially vulnerable risk groups like pregnant women and their developing fetuses, but nanomedicine offers promise for pregnancy treatment. Studies on ex vivo human placental perfusion of NPs reveal characteristics such as size and surface modifications influence placental uptake and transfer significantly, highlighting the need for relevant controls in future studies. Ex vivo placental perfusion model shows potential in revealing insights on NP effects on placental tissue functionality, impacting maternal-fetal health indirectly.

PLACENTA (2021)

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Review Chemistry, Multidisciplinary

Stem Cells for Next Level Toxicity Testing in the 21st Century

Ellen Fritsche et al.

Summary: The call for a paradigm change in toxicology initiated by the United States National Research Council in 2007 highlights the importance of human-relevant alternative methods for toxicological hazard assessment. This review article discusses critical organs such as skin, brain, and lungs in terms of their functions in health and disease, emphasizing the need for more complex organotypic models. Innovative technologies like organs-on-a-chip and genome editing are paving the way for a shift in toxicological paradigm towards more advanced and human-specific approaches.

SMALL (2021)

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Review Biochemistry & Molecular Biology

Nanotechnology for Topical Drug Delivery to the Anterior Segment of the Eye

Alexander Vaneev et al.

Summary: Topical drug delivery for eye therapy is challenging due to short retention time, insufficient contact with epithelium, fast elimination, and difficulties in overcoming ocular tissue barriers. Various conventional and novel drug delivery systems, particularly nanosize carriers, have been developed to improve drug bioavailability and enhance therapeutic action for eye diseases. Promising results have been shown with drug-loaded nanoparticles for sustained drug release and improved efficacy in vitro and in vivo.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biochemistry & Molecular Biology

On Placental Toxicology Studies and Cerium Dioxide Nanoparticles

Gaelle Deval et al.

Summary: The human placenta plays crucial roles in supporting pregnancy, fetal development, and growth through its various functions. Cerium dioxide nanoparticles (CeO2 NPs) are emerging pollutants that may impact placental function and pregnancy outcomes. Further research is needed to explore the relationship between CeO2 exposure and placental dysfunction, as well as its implications for pregnancy outcomes.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biotechnology & Applied Microbiology

Distribution of polymeric nanoparticles in the eye: implications in ocular disease therapy

Sean Swetledge et al.

Summary: Polymeric nanoparticles as drug delivery systems offer advantages such as controlled release, enhanced drug stability and bioavailability, and specific tissue targeting. However, their properties, administration route, and suspension media can impact their distribution and effectiveness in the eye, requiring careful design for specific target tissues and ocular diseases.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Review Cell Biology

The Impact of Oxidative Stress on Blood-Retinal Barrier Physiology in Age-Related Macular Degeneration

Annamaria Tisi et al.

Summary: The blood retinal barrier (BRB) undergoes changes in age-related macular degeneration (AMD), leading to retinal dysfunction and neurodegeneration. Oxidative stress is widely recognized as a key factor in AMD. The use of cerium oxide nanoparticles may be a new approach to combat AMD.

CELLS (2021)

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Article Cell Biology

Toxic effect of titanium dioxide nanoparticles on corneas in vitro and in vivo

Junxing Yang et al.

Aging-US (2021)

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Article Environmental Sciences

An inadvertent issue of human retina exposure to endocrine disrupting chemicals: A safety assessment

Minghui Li et al.

Summary: Endocrine disrupting chemicals (EDCs) can disrupt hormone balance and lead to physiological abnormalities, affecting ocular diseases. Despite EDCs passing through the blood-retinal barrier and accumulating in the neural retina, research on their impact remains limited.

CHEMOSPHERE (2021)

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Review Pharmacology & Pharmacy

Advanced nanodelivery platforms for topical ophthalmic drug delivery

Shima Gholizadeh et al.

Summary: By integrating nanotechnology, biomaterials, and polymer chemistry, recent and innovative nanodrug delivery platforms offer precise spatial and temporal control over sustained drug release to the cornea, improving drug bioavailability and reducing the frequency of eyedrop instillation.

DRUG DISCOVERY TODAY (2021)

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Review Biochemical Research Methods

Nanomicelles: Types, properties and applications in drug delivery

Anamika Bose et al.

Summary: Nanomicelles are unique colloid dispersions with a hydrophobic core and hydrophilic shell, making them ideal for drug delivery and other biological applications. Their small size, solubility, and customisable surface contribute to their multifunctionality.

IET NANOBIOTECHNOLOGY (2021)

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Review Nanoscience & Nanotechnology

Carbon Nanotubes: Smart Drug/GeneDelivery Carriers

Hossein Zare et al.

Summary: Carbon nanotubes have unique properties that make them suitable for drug and gene delivery, as well as applications in cancer therapy, anti-inflammatory treatments, and phototherapy. However, concerns about nanotoxicity and environmental impact remain, despite decades of research and potential benefits.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

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Article Ophthalmology

Toxicity Evaluation of a Novel Rapamycin Liposomal Formulation After Subconjunctival and Intravitreal Injection

Pedro Javier Salas-Ambrosio et al.

Summary: The study evaluated the safety and toxicity of a novel liposome-encapsulated rapamycin formulation in animal ocular administration. Results indicated no significant toxicity with SCJ or IVT injections, making it a potential alternative immunosuppressive treatment for immune-mediated eye pathologies.

JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS (2021)

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Article Chemistry, Multidisciplinary

Therapeutic Nanoparticles from Grape Seed for Modulating Oxidative Stress

Tianyou Wang et al.

Summary: The study reports a direct fabrication strategy towards polyphenol nanoparticles with tunable size, excellent biocompatibility, and reactive oxygen species (ROS) scavenging capacities from grape seed via an enzymatic polymerization method. The resulting nanoparticles can efficiently prevent cell damage from ROS and exert promising in vivo antioxidant therapeutic effects on several oxidative stress-related diseases. This research can stimulate the development of more kinds of low-cost, safe, and efficient biomass-based antioxidative nanomaterials via similar fabrication methodologies.

SMALL (2021)

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Article Toxicology

Cellular uptake and toxicity of gold nanoparticles on two distinct hepatic cell models

Maria Enea et al.

Summary: The study compared the cytotoxic effects of gold nanoparticles with different size, shape, and capping on liver cells, finding that smaller 15 nm spheres displayed the highest toxicity. Toxicological effects were influenced by capping, size, and cell type, with citrate-capped nanoparticles more toxic than MUA, 15 nm nanoparticles more toxic than 60 nm ones, and primary rat hepatocytes more sensitive than HepaRG cells. The presence of FBS significantly influenced toxicity outcomes, with higher internalization of AuNPs in PRH compared to HepaRG cells.

TOXICOLOGY IN VITRO (2021)

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Article Pharmacology & Pharmacy

Nanosafety vs. nanotoxicology: adequate animal models for testing in vivo toxicity of nanoparticles

Vladimir V. Chrishtop et al.

Summary: Nanotoxicological studies often encounter a paradox where nanoparticles can be retained in cells for a long time without causing significant toxic effects, but age-related processes and diseases can change distribution routes and make the use of nanomaterial unsafe. Current research on nanotoxicity in animals models with chronic diseases is unsystematic, despite demonstrating new toxic effects that are not present in healthy animals.

TOXICOLOGY (2021)

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Article Cell Biology

The Impact of Particulate Matter (PM2.5) on Human Retinal Development in hESC-Derived Retinal Organoids

Yuxiao Zeng et al.

Summary: The study demonstrated that PM2.5 exposure affected the formation of neural retina derived from hEROs, leading to reduced proliferation and increased apoptosis. Transcriptome analysis showed that PM2.5 treatment was linked to MAPK and PI3K/Akt pathways, and reduced the level of FGFs, particularly FGF8 and FGF10, suggesting potential inhibition of proliferation and increase of apoptosis during early human retinal development.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Polymer Science

Hyaluronic Acid-Based Gold Nanoparticles for the Topical Delivery of Therapeutics to the Retina and the Retinal Pigment Epithelium

Amine Laradji et al.

Summary: The ocular immune privilege protects the eye from immune responses but hinders drug delivery to the back of the eye. Hyaluronic acid-coated gold nanoparticles show potential as drug delivery vehicles to the retina, with enhanced distribution in the posterior segment and no adverse effects on visual function in mice.

POLYMERS (2021)

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Article Chemistry, Applied

Chitosan coated nanoparticles for efficient delivery of bevacizumab in the posterior ocular tissues via subconjunctival administration

Jayamanti Pandit et al.

Summary: The study evaluated the chitosan-coated poly (lactide-co-glycolic acid) nanoparticles for sustained and effective delivery of bevacizumab to posterior ocular tissues. The results showed better penetration and higher concentration of bevacizumab in posterior ocular tissues, and demonstrated more reduction of VEGF level in retina in a retinopathy model, suggesting the potential utility of CS-coated PLGA NPs as carriers to target the retina.

CARBOHYDRATE POLYMERS (2021)

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Article Ophthalmology

Acyclovir-Loaded Nanoemulsions: Preparation, Characterization and Irritancy Studies for Ophthalmic Delivery

Mojdeh Mohammadi et al.

Summary: This study aimed to develop and evaluate nanoemulsions containing acyclovir for ophthalmic drug delivery. Through component screening and evaluation, NE formulations with desirable physicochemical properties were developed, showing sustained drug release and safety for ocular administration. The results suggest that ACV-loaded NEs could be an effective and safe platform for ophthalmic delivery of ACV.

CURRENT EYE RESEARCH (2021)

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Article Materials Science, Biomaterials

Antimicrobial Action of Biocompatible Silver Microspheres and Their Role in the Potential Treatment of Fungal Keratitis

Hanhan Shi et al.

Summary: The study introduced a novel silver-based biomaterial, AgMPs, with favorable biocompatibility and enhanced antimicrobial activity. AgMPs showed significant antimicrobial action against bacteria and fungi, as well as biosafety on corneal epithelial cells, making them a potential candidate for treating fungal keratitis.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2021)

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Article Biotechnology & Applied Microbiology

Intravitreal quantum dots for retinitis pigmentosa: a first-in-human safety study

Timothy L. Jackson et al.

Summary: The study on the use of quantum dots (QDs) for treating RP showed that it is safe and beneficial for patients. Further validation studies are needed to confirm the potential of QDs in improving vision for RP patients.

NANOMEDICINE (2021)

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Review Pharmacology & Pharmacy

Nanoemulsions as Ophthalmic Drug Delivery Systems

Rasha Khalid Dhahir et al.

Summary: Nanoemulsions are liquid-in-liquid dispersion with a droplet size of about 100 nm, characterized by transparent appearance, high bioavailability, and extended shelf life. They are mainly composed of oil, water, surfactant, and cosurfactant and can be prepared by high- and low-energy methods.

TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES (2021)

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Article Biochemistry & Molecular Biology

Novel Thiol Containing Hybrid Antioxidant-Nitric Oxide Donor Small Molecules for Treatment of Glaucoma

Charles E. Amankwa et al.

Summary: Oxidative stress-induced death and dysregulation of trabecular meshwork (TM) cells contribute to increased intraocular pressure (IOP) in primary open angle (POAG) glaucoma, while nitric oxide (NO) can lower IOP by reducing reactive oxygen species (ROS). The novel sulfur containing hybrid NO donor-antioxidants were designed to scavenge ROS and maintain NO bioavailability in TM cells, demonstrating potential for glaucoma treatment. The slow-release nanosuspension of these molecules significantly lowered IOP in a mouse model, showing lasting effects up to 72 hours.

ANTIOXIDANTS (2021)

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Review Chemistry, Physical

A state of the art review on the synthesis, antibacterial, antioxidant, antidiabetic and tissue regeneration activities of zinc oxide nanoparticles

Th Abhishek Singh et al.

Summary: Zinc oxide nanoparticles (ZnONPs) have garnered significant interest in nanobiotechnology for their diverse biomedical applications, serving as antibacterial, antioxidant, and antidiabetic agents, as well as playing a role in bone and soft-tissue regeneration for tissue engineering. Their future perspectives and mechanisms of action are also being explored.

ADVANCES IN COLLOID AND INTERFACE SCIENCE (2021)

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Article Chemistry, Analytical

Dopamine Imaging in Living Cells and Retina by Surface-Enhanced Raman Scattering Based on Functionalized Gold Nanoparticles

Xueqian Ren et al.

Summary: Retinal dopamine is crucial in the development of myopia, and the visualization of dopamine with high spatial precision is essential for understanding the biochemical mechanism. The surface-enhanced Raman scattering (SERS) technique provides a new way to detect dopamine in cells and retinal tissues, contributing to the research of myopia.

ANALYTICAL CHEMISTRY (2021)

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Review Pharmacology & Pharmacy

An Overview of Copper Nanoparticles: Synthesis, Characterisation and Anti-cancer Activity

Gowhar Naikoo et al.

Summary: This review summarizes the different methods for copper nanoparticle synthesis, emphasizing the preference for green sources. It also critically reviews the effectiveness of copper-based nanoparticles in oncogenic treatments and highlights recent progress in their applications for cancer therapies.

CURRENT PHARMACEUTICAL DESIGN (2021)

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Article Toxicology

Ocular toxicity assessment of nanoemulsion in-situ gel formulation of fluconazole

M. S. Samimi et al.

Summary: The study aimed to develop an optimized fluconazole nanoemulsion in-situ gel formulation to improve ocular bioavailability of fluconazole. The formulation was found to be non-toxic and non-irritant to eye tissues, making it a suitable and safe alternative for future ocular delivery of fluconazole.

HUMAN & EXPERIMENTAL TOXICOLOGY (2021)

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Article Biochemistry & Molecular Biology

Sirolimus loaded chitosan functionalized poly (lactic-co-glycolic acid) (PLGA) nanoparticles for potential treatment of age-related macular degeneration

Reshal Suri et al.

Summary: Sirolimus-loaded PLGA nanoparticles and chitosan-decorated PLGA nanoparticles showed improved therapeutic effects in vitro and at the cellular level, as well as demonstrated safety in various analyses. SIR-CH-PLGA-NP exhibited higher anti-angiogenic potential compared to SIR-PLGA-NP, suggesting a new direction for further research on using CH-PLGA-NP as a SIR nanocarrier for AMD treatment.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Review Nanoscience & Nanotechnology

Ten Years of Knowledge of Nano-Carrier Based Drug Delivery Systems in Ophthalmology: Current Evidence, Challenges, and Future Prospective

Jie Zhang et al.

Summary: The complex drug delivery barrier in the eye can be overcome by utilizing nanotechnology and various nano-carriers to enhance drug bioavailability, retention time, and permeability in the eye. These approaches hold great potential for treating ocular diseases effectively.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

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Article Nanoscience & Nanotechnology

Size-Dependent Cytotoxicity and Reactive Oxygen Species of Cerium Oxide Nanoparticles in Human Retinal Pigment Epithelia Cells

Yuanyuan Ma et al.

Summary: This study investigated the cytotoxicity and ROS production of CeO2 NPs in human retinal pigment epithelial cells, finding that 15 nm CeO2 NPs exhibited the highest toxicity, causing excessive ROS generation and mitochondrial membrane potential depolarization in a dose- and time-dependent manner in the cells. The cytotoxicity was partially attenuated by the ROS scavenger NAC.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

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Article Pharmacology & Pharmacy

A non-invasive nanoparticle-based sustained dual-drug delivery system as an eyedrop for endophthalmitis

Binapani Mahaling et al.

Summary: A non-invasive dual-drug delivery system using nanoparticles in eye drops, loaded with azithromycin and triamcinolone acetonide, shows potential as a treatment for endophthalmitis, with antimicrobial and anti-inflammatory effects.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

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Article Chemistry, Multidisciplinary

Systemic dendrimer nanotherapies for targeted suppression of choroidal inflammation and neovascularization in age-related macular degeneration

Siva P. Kambhampati et al.

Summary: The study demonstrates a potential systemic therapy approach for selectively targeting and inhibiting the progression of AMD, showing promising efficacy in animal models and human postmortem studies.

JOURNAL OF CONTROLLED RELEASE (2021)

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Article Chemistry, Multidisciplinary

Nanoceria Prevents Glucose-Induced Protein Glycation in Eye Lens Cells

Belal Hanafy et al.

Summary: Nanoceria delays cataract progression through multiple mechanisms including mimicking catalase, improving cellular redox state, and inhibiting glucose-induced glycation of lens proteins.

NANOMATERIALS (2021)

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Review Cell Biology

Organoid Technology: A Reliable Developmental Biology Tool for Organ-Specific Nanotoxicity Evaluation

Minakshi Prasad et al.

Summary: Engineered nanomaterials possess unique physicochemical properties that make them suitable for diverse biomedical and pharmaceutical applications. Toxicity assessment of these materials is crucial for ensuring safety, and the use of organoid models shows potential advantages in this regard.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Review Biochemistry & Molecular Biology

A Systematic Review of Carotenoids in the Management of Age-Related Macular Degeneration

Drake W. Lem et al.

Summary: Age-related macular degeneration (AMD) is a leading cause of vision loss in older adults, with oxidative injury and compromised antioxidant defenses playing key roles in retinal neurodegeneration. Studies have shown that carotenoids such as lutein can provide neuroprotective effects in AMD patients, improving visual function and serving as adjunctive therapy in disease management.

ANTIOXIDANTS (2021)

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Review Ophthalmology

The utility and risks of therapeutic nanotechnology in the retina

Melanie Scheive et al.

Summary: The clinical application of nanotechnology in medicine shows promise in improving therapeutic, diagnostic, and surgical interventions. Nanotechnology in nano-ophthalmology, particularly in addressing retinal diseases, has the potential to enhance drug delivery systems and improve disease detection techniques for earlier and more accurate diagnosis.

THERAPEUTIC ADVANCES IN OPHTHALMOLOGY (2021)

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Review Gastroenterology & Hepatology

Organoids to model liver disease

Sandro Nuciforo et al.

Summary: The organoid model is a major breakthrough in cell biology, capable of recapitulating the morphological and functional features of in vivo tissues. Liver organoids, as a new type of cell model, have significant potential applications in the study of liver diseases.

JHEP REPORTS (2021)

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Article Ophthalmology

Preparation, Characterization, and Evaluation of Zinc Oxide Nanoparticles Suspension as an Antimicrobial Media for Daily Use Soft Contact Lenses

Maryam Shayani Rad et al.

CURRENT EYE RESEARCH (2020)

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Article Ophthalmology

Anti-microbial Effect and in Vivo Ocular Delivery of Ciprofloxacin-loaded Liposome through Rabbit's Eye

Mostafa Feghhi et al.

CURRENT EYE RESEARCH (2020)

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Article Biochemistry & Molecular Biology

The Inhibitory Effects of Gold Nanoparticles on VEGF-A-Induced Cell Migration in Choroid-Retina Endothelial Cells

Chi-Ming Chan et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Medicine, Research & Experimental

Sirolimus loaded polyol modified liposomes for the treatment of Posterior Segment Eye Diseases

Reshal Suri et al.

MEDICAL HYPOTHESES (2020)

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Review Biochemistry & Molecular Biology

The History of Nanoscience and Nanotechnology: From Chemical-Physical Applications to Nanomedicine

Samer Bayda et al.

MOLECULES (2020)

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Article Biochemistry & Molecular Biology

Treatment of Human Lens Epithelium with High Levels of Nanoceria Leads to Reactive Oxygen Species Mediated Apoptosis

Belal Hanafy et al.

MOLECULES (2020)

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Article Cell Biology

Copper induce zebrafish retinal developmental defects via triggering stresses and apoptosis

Guang Zhao et al.

CELL COMMUNICATION AND SIGNALING (2020)

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Article Nanoscience & Nanotechnology

Silver Nanoparticle-Induced Apoptosis in ARPE-19 Cells Is Inhibited by Toxoplasma gondii Pre-Infection Through Suppression of NOX4-Dependent ROS Generation

Juan-Hua Quan et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2020)

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Review Chemistry, Multidisciplinary

Carbon Nanotubes in Biomedicine

Viviana Negri et al.

TOPICS IN CURRENT CHEMISTRY (2020)

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Review Chemistry, Multidisciplinary

Advances and limitations of drug delivery systems formulated as eye drops

Clotilde Jumelle et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Review Chemistry, Multidisciplinary

A Review on Antimicrobial Properties of Metal Nanoparticles

Saee Gharpure et al.

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY (2020)

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Article Ophthalmology

Micelles: Promising Ocular Drug Carriers for Anterior and Posterior Segment Diseases

Meltem Ezgi Durgun et al.

JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS (2020)

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Article Nanoscience & Nanotechnology

Inhibition of choroidal neovascularization by systemic delivery of gold nanoparticles

Rupesh Singh et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2020)

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Article Engineering, Biomedical

Dually functional hollow ceria nanoparticle platform for intraocular drug delivery: A push beyond the limits of static and dynamic ocular barriers toward glaucoma therapy

Li-Jyuan Luo et al.

BIOMATERIALS (2020)

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Article Ophthalmology

Targeted delivery of mitomycin C-loaded and LDL-conjugated mesoporous silica nanoparticles for inhibiting the proliferation of pterygium subconjunctival fibroblasts

Mengliang Wu et al.

EXPERIMENTAL EYE RESEARCH (2020)

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Article Ophthalmology

Biological functions of tear film

Stephen C. Pflugfelder et al.

EXPERIMENTAL EYE RESEARCH (2020)

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Review Chemistry, Multidisciplinary

Polymeric Nanoparticles for Drug Delivery: Recent Developments and Future Prospects

Belen Begines et al.

NANOMATERIALS (2020)

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Article Pharmacology & Pharmacy

Nanoemulsion as a feasible and biocompatible carrier for ocular delivery of travoprost: Improved pharmacokinetic/pharmacodynamic properties

Ayman Ismail et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

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Article Cell Biology

Nanoceria Particles Are an Eligible Candidate to Prevent Age-Related Macular Degeneration by Inhibiting Retinal Pigment Epithelium Cell Death and Autophagy Alterations

Annamaria Tisi et al.

CELLS (2020)

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Article Pharmacology & Pharmacy

Nanodelivery of Resveratrol-Loaded PLGA Nanoparticles for Age-Related Macular Degeneration

Priyanka Bhatt et al.

AAPS PHARMSCITECH (2020)

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Article Ophthalmology

Bevacizumab-Conjugated Quantum Dots:In VitroAntiangiogenic Potential and Biosafety in Rat Retina

Cleildo P. Santana et al.

JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS (2020)

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Review Toxicology

Recent insights on indirect mechanisms in developmental toxicity of nanomaterials

Battuja Batbajar Dugershaw et al.

PARTICLE AND FIBRE TOXICOLOGY (2020)

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Article Ophthalmology

Hyaluronic acid coating of gold nanoparticles for intraocular drug delivery: Evaluation of the surface properties and effect on their distribution

P. S. Apaolaza et al.

EXPERIMENTAL EYE RESEARCH (2020)

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Review Chemistry, Multidisciplinary

Therapeutic nanoemulsions in ophthalmic drug administration: Concept in formulations and characterization techniques for ocular drug delivery

Mahendra Singh et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Review Biochemistry & Molecular Biology

Utilization of Polymer-Lipid Hybrid Nanoparticles for Targeted Anti-Cancer Therapy

Ayeskanta Mohanty et al.

MOLECULES (2020)

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Article Nanoscience & Nanotechnology

Self-assembled DNA nanoparticles loaded with travoprost for glaucoma-treatment

Sven Schnichels et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2020)

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Article Multidisciplinary Sciences

Systemic anti-inflammatory therapy aided by double-headed nanoparticles in a canine model of acute intraocular inflammation

R. Ganugula et al.

SCIENCE ADVANCES (2020)

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Review Materials Science, Biomaterials

Emerging Trends in Nanomedicine for Improving Ocular Drug Delivery: Light-Responsive Nanoparticles, Mesoporous Silica Nanoparticles, and Contact Lenses

Flavia S. C. Rodrigues et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2020)

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Article Ophthalmology

Penetration of Carbon Nanotubes into the Retinoblastoma Tumor after Intravitreal Injection in LHBETATAG Transgenic Mice Reti-noblastoma Model

Hakan Demirci et al.

JOURNAL OF OPHTHALMIC & VISION RESEARCH (2020)

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Review Chemistry, Medicinal

Nanotechnology for the Treatment of Allergic Conjunctival Diseases

Yu-Chi Liu et al.

PHARMACEUTICALS (2020)

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Review Medicine, Research & Experimental

Polymer-hybrid nanoparticles: Current advances in biomedical applications

Daniel Cristian Ferreira Soares et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Review Chemistry, Physical

Microphysiological Systems: Next Generation Systems for Assessing Toxicity and Therapeutic Effects of Nanomaterials

Nureddin Ashammakhi et al.

SMALL METHODS (2020)

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Review Public, Environmental & Occupational Health

Nanoparticles induced embryo-fetal toxicity

Zengjin Wang et al.

TOXICOLOGY AND INDUSTRIAL HEALTH (2020)

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Review Toxicology

Potential risks and benefits of zinc oxide nanoparticles: a systematic review

S. Keerthana et al.

CRITICAL REVIEWS IN TOXICOLOGY (2020)

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Review Ophthalmology

Novel drug delivery systems for ocular therapy: With special reference to liposomal ocular delivery

Arpita Bhattacharjee et al.

EUROPEAN JOURNAL OF OPHTHALMOLOGY (2019)

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Review Chemistry, Medicinal

Gold nanoparticles in ophthalmology

Florence Masse et al.

MEDICINAL RESEARCH REVIEWS (2019)

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Review Pharmacology & Pharmacy

Topical application of polymeric nanomicelles in ophthalmology: a review on research efforts for the noninvasive delivery of ocular therapeutics

Maria Aurora Grimaudo et al.

EXPERT OPINION ON DRUG DELIVERY (2019)

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Article Nanoscience & Nanotechnology

Mesoporous silica nanoparticles as a delivery system for improving antiangiogenic therapy

Jian-Guo Sun et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2019)

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Review Nanoscience & Nanotechnology

Lipid-polymer hybrid nanoparticles as a next-generation drug delivery platform: state of the art, emerging technologies, and perspectives

Anubhab Mukherjee et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2019)

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Review Medicine, Research & Experimental

Glaucoma: Current treatment and impact of advanced drug delivery systems

Khushwant S. Yadav et al.

LIFE SCIENCES (2019)

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Review Medicine, General & Internal

Update on the association between dry eye disease and meibomian gland dysfunction

Tommy C. Y. Chan et al.

HONG KONG MEDICAL JOURNAL (2019)

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Article Ophthalmology

Retinal long term neuroprotection by Cerium Oxide nanoparticles after an acute damage induced by high intensity light exposure

A. Tisi et al.

EXPERIMENTAL EYE RESEARCH (2019)

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Review Pharmacology & Pharmacy

Ocular Drug Delivery: Present Innovations and Future Challenges

Vrinda Gote et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2019)

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Article Multidisciplinary Sciences

Contrast Agent Enhanced Multimodal Photoacoustic Microscopy and Optical Coherence Tomography for Imaging of Rabbit Choroidal and Retinal Vessels in vivo

Van Phuc Nguyen et al.

SCIENTIFIC REPORTS (2019)

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Review Pharmacology & Pharmacy

Challenges and opportunities for drug delivery to the posterior of the eye

Fernando J. Cabrera et al.

DRUG DISCOVERY TODAY (2019)

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Article Biotechnology & Applied Microbiology

Potential Antimicrobial Applications of Chitosan Nanoparticles (ChNP)

Nur Amiera Syuhada Rozman et al.

JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY (2019)

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Article Biotechnology & Applied Microbiology

Gold nanoparticles for multimodal high-resolution imaging of transplanted cells for retinal replacement therapy

Yoav Chemla et al.

NANOMEDICINE (2019)

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Review Chemistry, Multidisciplinary

Safety Assessment of Nanomaterials to Eyes: An Important but Neglected Issue

Shuang Zhu et al.

ADVANCED SCIENCE (2019)

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Review Ophthalmology

Quantum Dots in Ophthalmology: A Literature Review

Sidra Sarwat et al.

CURRENT EYE RESEARCH (2019)

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Article Biochemistry & Molecular Biology

Synthesis of Ultrastable Gold Nanoparticles as a New Drug Delivery System

Florence Masse et al.

MOLECULES (2019)

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Review Polymer Science

Advances in Biodegradable Nano-Sized Polymer-Based Ocular Drug Delivery

Courtney Lynch et al.

POLYMERS (2019)

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Review Environmental Sciences

The potential exposure and hazards of copper nanoparticles: A review

Thelma Ameh et al.

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY (2019)

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Article Pharmacology & Pharmacy

Stability, Cytotoxicity, and Retinal Pigment Epithelial Cell Binding of Hyaluronic Acid-Coated PLGA Nanoparticles Encapsulating Lutein

Chuda Chittasupho et al.

AAPS PHARMSCITECH (2019)

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Review Medicine, Research & Experimental

Anti-inflammatory mechanism of various metal and metal oxide nanoparticles synthesized using plant extracts: A review

Happy Agarwal et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

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Article Chemistry, Multidisciplinary

A cerium oxide loaded glycol chitosan nano-system for the treatment of dry eye disease

Fan Yu et al.

JOURNAL OF CONTROLLED RELEASE (2019)

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Review Nanoscience & Nanotechnology

Fundamentals, challenges, and nanomedicine-based solutions for ocular diseases

Dadi A. Srinivasarao et al.

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY (2019)

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Article Toxicology

In Vitro Cytotoxicity of Zinc Oxide Nanoparticles in Cultured Statens Seruminstitut Rabbit Cornea Cells

Handule Lee et al.

TOXICOLOGICAL RESEARCH (2019)

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Review Medicine, General & Internal

Copper and copper nanoparticles toxicity and their impact on basic functions in the body

M. Pohanka

BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY (2019)

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Article Ophthalmology

In vivo and in vitro toxicity evaluation of liposome-encapsulated sirolimus

Murilo Batista Abud et al.

INTERNATIONAL JOURNAL OF RETINA AND VITREOUS (2019)

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Review Ophthalmology

A Focus on the Epidemiology of Uveitis

Theodora Tsirouki et al.

OCULAR IMMUNOLOGY AND INFLAMMATION (2018)

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Review Medicine, Research & Experimental

Nanostructured lipid carriers for site-specific drug delivery

Archana Khosa et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

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Review Neurosciences

Strategies to Reduce Oxidative Stress in Glaucoma Patients

Maria D. Pinazo-Duran et al.

CURRENT NEUROPHARMACOLOGY (2018)

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Article Ophthalmology

Ocular toxicity of reduced graphene oxide or graphene oxide exposure in mouse eyes

Wenzhen An et al.

EXPERIMENTAL EYE RESEARCH (2018)

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Article Biochemistry & Molecular Biology

Antifungal, antioxidant and cytotoxic activities of chitosan nanoparticles and its use as an edible coating on vegetables

K. Divya et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2018)

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Review Chemistry, Multidisciplinary

Polymer-based carriers for ophthalmic drug delivery

Julieta C. Imperiale et al.

JOURNAL OF CONTROLLED RELEASE (2018)

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Article Engineering, Environmental

Transcriptional responses and mechanisms of copper nanoparticle toxicology on zebrafish embryos

YanJun Zhang et al.

JOURNAL OF HAZARDOUS MATERIALS (2018)

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Article Immunology

An inhibitory action of chitosan nanoparticles against pathogenic bacteria and fungi and their potential applications as biocompatible antioxidants

D. MubarakAli et al.

MICROBIAL PATHOGENESIS (2018)

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Review Medicine, General & Internal

Dry Eye

Janine A. Clayton

NEW ENGLAND JOURNAL OF MEDICINE (2018)

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Article Biotechnology & Applied Microbiology

Zinc oxide nanoparticles induce murine photoreceptor cell death via mitochondria-related signaling pathway

Ling Wang et al.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2018)

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Review Medicine, Research & Experimental

A review on recent drug delivery systems for posterior segment of eye

Kritika Nayak et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

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Article Environmental Sciences

Silver nanoparticles affect lens rather than retina development in zebrafish embryos

YanJun Zhang et al.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2018)

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Article Toxicology

Nanoparticles in Daily Life: Applications, Toxicity and Regulations

Ritu Gupta et al.

JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY (2018)

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Review Medicine, General & Internal

Age-related macular degeneration

Paul Mitchell et al.

LANCET (2018)

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Review Physiology

Autophagy Dysfunction and Oxidative Stress, Two Related Mechanisms Implicated in Retinitis Pigmentosa

Mari-Luz Moreno et al.

FRONTIERS IN PHYSIOLOGY (2018)

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Review Nanoscience & Nanotechnology

Potential adverse effects of nanoparticles on the reproductive system

Ruolan Wang et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2018)

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Article Ophthalmology

Potential Role of Oxidative Stress in Ocular Surface Inflammation and Dry Eye Disease

Murat Dogru et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2018)

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Review Pharmacology & Pharmacy

Extended ocular drug delivery systems for the anterior and posterior segments: biomaterial options and applications

Jennifer J. Kang-Mieler et al.

EXPERT OPINION ON DRUG DELIVERY (2017)

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Review Infectious Diseases

Metal oxide nanoparticles as antimicrobial agents: a promise for the future

Azhwar Raghunath et al.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2017)

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Review Pharmacology & Pharmacy

Non-invasive strategies for targeting the posterior segment of eye

Asadullah Madni et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2017)

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Review Medicine, General & Internal

Cataracts

Yu-Chi Liu et al.

LANCET (2017)

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Article Nanoscience & Nanotechnology

Potential of CeCl3@mSiO2 nanoparticles in alleviating diabetic cataract development and progression

Jin Yang et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2017)

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Article Nanoscience & Nanotechnology

Intraocular application of gold nanodisks optically tuned for optical coherence tomography: inhibitory effect on retinal neovascularization without unbearable toxicity

Hyun Beom Song et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2017)

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Review Nanoscience & Nanotechnology

Nano-ophthalmology: Applications and considerations

Mohammad Amin Kamaleddin

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2017)

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Review Pharmacology & Pharmacy

Principles of pharmacology in the eye

Sahar Awwad et al.

BRITISH JOURNAL OF PHARMACOLOGY (2017)

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Review Medicine, Research & Experimental

Oxidative stress and reactive oxygen species: a review of their role in ocular disease

Lawson Ung et al.

CLINICAL SCIENCE (2017)

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Review Pharmacology & Pharmacy

Nanoparticles for drug delivery to the anterior segment of the eye

Dileep R. Janagam et al.

ADVANCED DRUG DELIVERY REVIEWS (2017)

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Article Nanoscience & Nanotechnology

Effects of metal-bearing nanoparticles (Ag, Au, CdS, ZnO, SiO2) on developing zebrafish embryos

Jose Maria Lacave et al.

NANOTECHNOLOGY (2016)

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Article Nanoscience & Nanotechnology

Evaluation of the toxicity of graphene oxide exposure to the eye

Wei Wu et al.

NANOTOXICOLOGY (2016)

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Article Toxicology

Biocompatibility of gold nanoparticles in retinal pigment epithelial cell line

Bedia Begum Karakocak et al.

TOXICOLOGY IN VITRO (2016)

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Review Ophthalmology

Drug Delivery Nanoparticles: Toxicity Comparison in Retinal Pigment Epithelium and Retinal Vascular Endothelial Cells

Haijiang Lin et al.

SEMINARS IN OPHTHALMOLOGY (2016)

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Article Multidisciplinary Sciences

The Effect of Silica Nanoparticles on Human Corneal Epithelial Cells

Joo-Hee Park et al.

SCIENTIFIC REPORTS (2016)

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Review Biotechnology & Applied Microbiology

Nanotoxicology: advances and pitfalls in research methodology

Morteza Azhdarzadeh et al.

NANOMEDICINE (2015)

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Article Nanoscience & Nanotechnology

Combined repeated-dose toxicity study of silver nanoparticles with the reproduction/developmental toxicity screening test

Jeong-Sup Hong et al.

NANOTOXICOLOGY (2014)

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Article Multidisciplinary Sciences

Silver and Gold Nanoparticles Exposure to In Vitro Cultured Retina - Studies on Nanoparticle Internalization, Apoptosis, Oxidative Stress, Glial- and Microglial Activity

Erika Soderstjerna et al.

PLOS ONE (2014)

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Article Biophysics

Ocular biocompatibility and tolerance study of biodegradable polymeric micelles in the rabbit eye

Lu Xu et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2013)

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Article Ophthalmology

Dermal and ocular irritation and skin sensitization studies of fullerene C60 nanoparticles

Makoto Ema et al.

CUTANEOUS AND OCULAR TOXICOLOGY (2013)

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Article Toxicology

Gold Nanoparticles Disrupt Zebrafish Eye Development and Pigmentation

Ki-Tae Kim et al.

TOXICOLOGICAL SCIENCES (2013)

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Article Nanoscience & Nanotechnology

The effect of high concentration and exposure duration of nanoceria on human lens epithelial cells

Barbara K. Pierscionek et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2012)

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Article Nanoscience & Nanotechnology

Release profile and transscleral permeation of triamcinolone acetonide loaded nanostructured lipid carriers (TA-NLC): in vitro and ex vivo studies

Joana Araujo et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2012)

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Article Nanoscience & Nanotechnology

Distribution of silver nanoparticles in pregnant mice and developing embryos

Carlye A. Austin et al.

NANOTOXICOLOGY (2012)

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Review Neurosciences

Mechanisms of Age-Related Macular Degeneration

Jayakrishna Ambati et al.

NEURON (2012)

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Article Ophthalmology

Effects of Gold Nanoparticles on Endotoxin-Induced Uveitis in Rats

David Valter Pereira et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2012)

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Article Chemistry, Medicinal

Studies of Intracorneal Distribution and Cytotoxicity of Quantum Dots: Risk Assessment of Eye Exposure

Tsung-Rong Kuo et al.

CHEMICAL RESEARCH IN TOXICOLOGY (2011)

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Article Ophthalmology

Antioxidant Status and Oxidative Stress in Primary Open Angle Glaucoma and Pseudoexfoliative Glaucoma

Mesut Erdurmus et al.

CURRENT EYE RESEARCH (2011)

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Article Medicine, Legal

Evaluation of dermal and eye irritation and skin sensitization due to carbon nanotubes

Makoto Ema et al.

REGULATORY TOXICOLOGY AND PHARMACOLOGY (2011)

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Review Endocrinology & Metabolism

Diabetic cataracts: mechanisms and management

Irina G. Obrosova et al.

DIABETES-METABOLISM RESEARCH AND REVIEWS (2010)

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Review Chemistry, Multidisciplinary

Silver nano - A trove for retinal therapies

Kalimuthu Kalishwaralal et al.

JOURNAL OF CONTROLLED RELEASE (2010)

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Article Medicine, General & Internal

Diabetic retinopathy

Ning Cheung et al.

LANCET (2010)

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Article Nanoscience & Nanotechnology

Nanoceria have no genotoxic effect on human lens epithelial cells

Barbara K. Pierscionek et al.

NANOTECHNOLOGY (2010)

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Article Ophthalmology

Applications of nanoparticles in ophthalmology

Yolanda Diebold et al.

PROGRESS IN RETINAL AND EYE RESEARCH (2010)

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Article Chemistry, Multidisciplinary

Cytotoxicity and Genotoxicity of Silver Nanoparticles in Human Cells

P. V. AshaRani et al.

ACS NANO (2009)

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Article

Toxicity and Environmental Risks of Nanomaterials: Challenges and Future Needs

PARESH CHANDRA RAY et al.

JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART C-ENVIRONMENTAL CARCINOGENESIS & ECOTOXICOLOGY REVIEWS (2009)

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Article Toxicology

Safety evaluation of highly purified fullerenes (HPFs): based on screening of eye and skin damage

Hisae Aoshima et al.

JOURNAL OF TOXICOLOGICAL SCIENCES (2009)

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Article Nanoscience & Nanotechnology

Intravenously administered gold nanoparticles pass through the blood-retinal barrier depending on the particle size, and induce no retinal toxicity

Jeong Hun Kim et al.

NANOTECHNOLOGY (2009)

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Article Toxicology

Assessment of the dermal and ocular irritation potential of multi-walled carbon nanotubes by using in vitro and in vivo methods

A. Sairam Kishore et al.

TOXICOLOGY LETTERS (2009)

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Review Medicine, General & Internal

Age-related macular degeneration

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