☆ 4.6 Review

The Advances of Broad-Spectrum and Hot Anti-Coronavirus Drugs

MICROORGANISMS (2022)

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Article Chemistry, Applied

New natural furfural derivatives from the leaves and stems of Pogostemon cablin

Yuanhao Wang et al.

Summary: A new furfural derivative (pogoscafuran A) and a new natural product (HMF levulinate) were isolated from Pogostemon cablin. Their structures were analyzed and a possible biogenetic pathway for the new compound was proposed. Compound 1 exhibited weak inhibitory activity against nitric oxide production.

NATURAL PRODUCT RESEARCH (2023)

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Article Medicine, General & Internal

Efficacy and safety of three new oral antiviral treatment (molnupiravir, fluvoxamine and Paxlovid) for COVID-19: a meta-analysis

Wen Wen et al.

Summary: This study conducted a meta-analysis on three new oral antivirals (molnupiravir, fluvoxamine, and Paxlovid) and their effects on mortality and hospitalization rates among COVID-19 patients. The results showed that these drugs were effective in reducing mortality and hospitalization rates by approximately 67%. Furthermore, the drugs did not increase adverse events, indicating good overall safety.

ANNALS OF MEDICINE (2022)

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Article Food Science & Technology

Xanthohumol reduces inflammation and cell metabolism in HT29 primary colon cancer cells

Margalida Torrens-Mas et al.

Summary: The study found that low doses of XN treatment did not significantly affect cell viability, but led to a general decrease in pro-inflammatory, antioxidant and mitochondrial biogenesis gene expression. Additionally, glucose and oxidative metabolism enzymes were also reduced.

INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION (2022)

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Article Biochemistry & Molecular Biology

Naphthoquine: A Potent Broad-Spectrum Anti-Coronavirus Drug In Vitro

Yabin Song et al.

Summary: This study found that the anti-malarial drug Naphthoquine exhibited broad-spectrum antiviral activity against coronaviruses and may function by inhibiting virus entry and replication. Naphthoquine showed superior safety compared to Chloroquine and has the potential to be a broad-spectrum drug for coronavirus infections.

MOLECULES (2022)

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Article Medicine, General & Internal

Oral Nirmatrelvir for High-Risk, Nonhospitalized Adults with Covid-19

Jennifer Hammond et al.

Summary: In high-risk, unvaccinated adults, treatment of Covid-19 with nirmatrelvir plus ritonavir can significantly reduce the risk of hospitalization and death, with good safety profile.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

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Article Chemistry, Multidisciplinary

Orally administered bismuth drug together with N-acetyl cysteine as a broad-spectrum anti-coronavirus cocktail therapy

Runming Wang et al.

Summary: The emergence of SARS-CoV-2 variants impacts vaccine efficacy, highlighting the importance of further developing orally administered anti-SARS-CoV-2 therapies. A cocktail therapy combining colloidal bismuth subcitrate or bismuth subsalicylate with N-acetyl-l-cysteine shows potent preclinical anti-SARS-CoV-2 efficacy, offering a potential at-home treatment for combating SARS-CoV-2 and future coronavirus infections.

CHEMICAL SCIENCE (2022)

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Article Microbiology

JIB-04 Has Broad-Spectrum Antiviral Activity and Inhibits SARS-CoV-2 Replication and Coronavirus Pathogenesis

Juhee Son et al.

Summary: Pathogenic coronaviruses pose a major threat to global public health. Researchers have identified JIB-04 as a small-molecule inhibitor that potently blocks the replication of SARS-CoV-2 and shows antiviral activity against multiple viruses. Animal studies have shown that JIB-04 can reduce virus infection and tissue pathology.

MBIO (2022)

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Article Multidisciplinary Sciences

Arrhythmogenic mechanisms of interleukin-6 combination with hydroxychloroquine and azithromycin in inflammatory diseases

Xiaojia Zhu et al.

Summary: Inflammatory diseases like COVID-19 are associated with a cytokine storm characterized by high levels of interleukin-6 (IL-6). This study aims to understand the electrophysiological basis of inflammation-associated arrhythmic risk with the presence of azithromycin (AZM) and hydroxychloroquine (HCQ). The results show that IL-6 alone or in combination with AZM and HCQ can cause mild to moderate reductions in heart rate, PR-interval, and corrected QT (QTc). IL-6 alone is more potent in affecting these measurements compared to the combination of drugs. Additionally, the combination of IL-6, AZM, and HCQ can lead to severe bradycardia, conduction abnormalities, and QTc prolongation. These abnormalities can be attenuated by tocilizumab (TCZ), a monoclonal antibody against IL-6 receptor, and are attributed to changes in action potentials and ion-currents. Inflammation poses a greater risk for arrhythmia than the drug combination therapy.

SCIENTIFIC REPORTS (2022)

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Article Biochemistry & Molecular Biology

Evaluating cepharanthine analogues as natural drugs against SARS-CoV-2

Atsushi Hijikata et al.

Summary: This study evaluated the potential of natural analogues of Cepharanthine as anti-coronavirus disease 2019 drugs through molecular docking simulations and cell-based SARS-CoV-2 infection assays. The diphenyl ester moiety of the molecules was suggested as a putative pharmacophore for the CEP analogues according to the docking conformations.

FEBS OPEN BIO (2022)

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Review Pharmacology & Pharmacy

Perspectives on the design and discovery of α-ketoamide inhibitors for the treatment of novel coronavirus: where do we stand and where do we go?

Alessio Nocentini et al.

Summary: Crystallography, previous drug design efforts, and many computational studies have provided a deeper understanding of the structural requirements for designing effective SARS-CoV-2 M-pro alpha-ketoamide inhibitors. However, all reported derivatives are peptidomimetics with a relatively high molecular weight. It is expected that future drug development will target effective compounds with lower molecular weights and a less peptidomimetic profile.

EXPERT OPINION ON DRUG DISCOVERY (2022)

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Review Chemistry, Applied

Why natural antioxidants are readily recognized by biological systems? 3D architecture plays a role!

Zai-Qun Liu

Summary: This study summarizes the common characteristics of over 70 natural antioxidants, finding that they all have three-dimensional (3D) architectures instead of mere planar structures. This 3D conformation is beneficial for natural antioxidants to be recognized by biological surroundings. Therefore, designing antioxidant structures should consider 3D architecture, and testing antioxidant effects using signaling pathways, protein targets, and cell lines is encouraged.

FOOD CHEMISTRY (2022)

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Article Biochemistry & Molecular Biology

Novel 2019 coronavirus structure, mechanism of action, antiviral drug promises and rule out against its treatment

Subramanian Boopathi et al.

Summary: The world has faced several infectious disease outbreaks in the past two decades, with the novel coronavirus 2019 having a significant global impact. With millions infected and thousands dead, only a few Asian countries have managed to control the disease, but a second wave of infections is expected. Predicting inhibitors and targets for COVID-19 is urgent, with computer-aided drug design playing a crucial role in this process.

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2021)

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Review Infectious Diseases

Azithromycin in the treatment of COVID-19: a review

Daniel Echeverria-Esnal et al.

Summary: Azithromycin shows antiviral and immunomodulatory properties, which may be beneficial in treating COVID-19. However, evidence for its use is scarce and of low quality.

EXPERT REVIEW OF ANTI-INFECTIVE THERAPY (2021)

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Letter Medicine, General & Internal

Reported Adverse Drug Reactions Associated With the Use of Hydroxychloroquine and Chloroquine During the COVID-19 Pandemic

Justine Perez et al.

ANNALS OF INTERNAL MEDICINE (2021)

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Article Microbiology

Off-Target In Vitro Profiling Demonstrates that Remdesivir Is a Highly Selective Antiviral Agent

Yili Xu et al.

Summary: Remdesivir is the first FDA-approved antiviral for COVID-19 treatment, with broad-spectrum activity against various coronaviruses. Studies have shown low off-target toxicity in cellular assays, indicating a favorable safety profile.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2021)

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Article Pharmacology & Pharmacy

Remdesivir: Quo vadis

Erik De Clercq

Summary: Remdesivir is the only antiviral drug formally approved by the US FDA for the treatment of Covid-19. Its key structural features and mode of action have been well established, but further optimization in clinical application is needed in terms of dosage, timing, route of administration, and potential combinations with other drugs for efficacy evaluation.

BIOCHEMICAL PHARMACOLOGY (2021)

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Article Biochemistry & Molecular Biology

Xanthohumol Is a Potent Pan-Inhibitor of Coronaviruses Targeting Main Protease

Yuxi Lin et al.

Summary: Xanthohumol, a small molecule from hops, has shown potent inhibitory effects against various coronaviruses by targeting M-pro, making it a promising antiviral drug candidate.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Medicine, General & Internal

Caution required with use of ritonavir-boosted PF-07321332 in COVID-19 management

Joseph Heskin et al.

LANCET (2021)

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Article Nanoscience & Nanotechnology

In vitro Study on Synergistic Interactions Between Free and Encapsulated Q-Griffithsin and Antiretrovirals Against HIV-1 Infection

Farnaz Minooei et al.

Summary: Co-administration of the oxidation-resistant variant griffithsin (Q-GRFT) with antiretrovirals (ARVs) in free or encapsulated forms may improve efficacy in achieving prophylaxis, showing synergistic interactions in in vitro assays.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

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Article Medicine, Research & Experimental

Protective effect of Rosuvastatin on Azithromycin induced cardiotoxicity in a rat model

Basma S. Mansour et al.

Summary: The study demonstrated that Rosuvastatin significantly ameliorates the toxic effects of Azithromycin on the heart, including ECG changes, biochemical markers, and oxidative stress. The histological and immunohistochemical results from the Rosuvastatin treated group showed restoration of cardiac muscle fibers, indicating a potential protective effect against Azithromycin-induced cardiotoxicity.

LIFE SCIENCES (2021)

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Article Multidisciplinary Sciences

SARS-CoV-2 infection is effectively treated and prevented by EIDD-2801

Angela Wahl et al.

Summary: The study suggests that bats may be the source of coronaviruses that can be directly transmitted to humans. Using the LoM model, efficient replication of SARS-CoV, MERS-CoV, SARS-CoV-2, and two SARS-like bat coronaviruses in human lung tissue was demonstrated. Infection with SARS-CoV-2 predominantly targets human lung epithelial cells and induces a sustained inflammatory response. The broad-spectrum antiviral agent EIDD-2801 significantly inhibits SARS-CoV-2 replication in vivo, showing potential for prevention and treatment of COVID-19.

NATURE (2021)

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Review Chemistry, Medicinal

Beware of Steroid-Induced Avascular Necrosis of the Femoral Head in the Treatment of COVID-19-Experience and Lessons from the SARS Epidemic

Shenqi Zhang et al.

Summary: The recent global outbreak of COVID-19 has raised important questions regarding the use of corticosteroid therapy, dosage, and duration, as well as prevention, early detection, and timely intervention of SANFH. Due to possible biases in the data selection and lack of large-scale research data support, more studies are needed to establish the gold standard for these issues.

DRUG DESIGN DEVELOPMENT AND THERAPY (2021)

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Article Virology

Antiviral Activities of Carbazole Derivatives against Porcine Epidemic Diarrhea Virus In Vitro

Zheng Chen et al.

Summary: This study found that some carbazole derivatives have inhibitory effects on PEDV replication and exhibit inhibition at the early stage. This provides evidence for these compounds to be potential inhibitors of PEDV, and offers candidates for the development of novel therapeutic agents.

VIRUSES-BASEL (2021)

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Article Pharmacology & Pharmacy

Epigallocatechin-3-Gallate, the Main Polyphenol in Green Tea, Inhibits Porcine Epidemic Diarrhea Virus In Vitro

Changchao Huan et al.

Summary: The natural molecule EGCG, found in green tea, is effective against PEDV infection at the cellular level by inhibiting attachment, entry, replication, and assembly processes of the virus.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Critical Care Medicine

Safety and efficacy of inhaled nebulised interferon beta-1a (SNG001) for treatment of SARS-CoV-2 infection: a randomised, double-blind, placebo-controlled, phase 2 trial

Phillip D. Monk et al.

Summary: The study evaluated the efficacy and safety of using interferon beta-1a to treat COVID-19, with results showing that patients who received treatment had higher and faster recovery rates, providing potential evidence for further clinical trials.

LANCET RESPIRATORY MEDICINE (2021)

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Article Medicine, Research & Experimental

Xanthohumol suppresses inflammation in chondrocytes and ameliorates osteoarthritis in mice

Ximiao Chen et al.

Summary: The research found that Xanthohumol (XN) can inhibit the expression of nitric oxide synthase (INOS), IL-1 beta-promoted inducible nitric oxide (NO), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and cyclooxygenase-2 (COX-2) in vitro. Additionally, it down-regulates matrix metalloproteinase-13 and prothrombin, while up-regulating type II collagen and Aggrecan expression. XN also activates nuclear factor (Nrf2) and inhibits nuclear factor B (NF-kappaB) signal transduction to slow down the progression of osteoarthritis.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Article Pharmacology & Pharmacy

Network Pharmacology-Based Analysis of Pogostemon cablin (Blanco) Benth Beneficial Effects to Alleviate Nonalcoholic Fatty Liver Disease in Mice

Yizhe Cui et al.

Summary: The study found that Pogostemon cablin can prevent and treat nonalcoholic fatty liver disease through various pathways and targets, including regulating lipid metabolism, anti-inflammatory, and antioxidant pathways. Pharmacological experiments demonstrated that Pogostemon cablin can reduce lipid accumulation and improve liver inflammation by inhibiting the activation of NF-kappa B/I kappa B signaling and decreasing the release of pro-inflammatory factors.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

Modelling sudden cardiac death risks factors in patients with coronavirus disease of 2019 the hydroxychloroquine and azithromycin case

Jerome Montnach et al.

Summary: Through the O'Hara-Rudy computer model, the study evaluates the arrhythmogenic potential of clinical factors in COVID-19 patients that can further alter repolarization, in addition to hydroxychloroquine and azithromycin, such as tachycardia, hypokalaemia, and subclinical to mild Long QT syndrome. The results show that hydroxychloroquine and azithromycin have little impact on QT duration and do not induce any substrate prone to arrhythmia in COVID-19 patients with normal cardiac repolarization reserve. However, in conditions with reduced repolarization reserve, there may be larger electrocardiogram impairments, as seen with dofetilide.

EUROPACE (2021)

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Review Endocrinology & Metabolism

Molnupiravir in COVID-19: A systematic review of literature

Awadhesh Kumar Singh et al.

Summary: Molnupiravir has shown significant benefits in reducing hospitalization or death in mild COVID-19 cases, making it a potential important tool in combating SARSCoV-2. However, its efficacy in moderate to severe COVID-19 remains uncertain, requiring further studies for clarification.

DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS (2021)

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Review Chemistry, Medicinal

Potential Anti-Coronavirus Agents and the Pharmacologic Mechanisms

Yang Yang et al.

Summary: SARS-CoV-2 is a novel pathogen with limited understanding of its pathogenesis, prompting further research. Current treatments include nucleoside analogues, protease inhibitors, and other drugs, which may offer new insights for COVID-19 treatment.

DRUG DESIGN DEVELOPMENT AND THERAPY (2021)

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Article Virology

Significant Inhibition of Porcine Epidemic Diarrhea Virus In Vitro by Remdesivir, Its Parent Nucleoside and β-d-N4-hydroxycytidine

Yuanchao Xie et al.

Summary: In recent years, the increased virulence of the porcine epidemic diarrhea virus has caused significant economic losses to the pig industry worldwide. Researchers have discovered three broad-spectrum antiviral nucleoside analogs, with RDV-N showing the strongest antiviral activity against PEDV. This compound has the potential to be a promising broad-spectrum antiviral nucleoside, with the need to enhance its oral bioavailability through structural modifications.

VIROLOGICA SINICA (2021)

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Review Virology

Porcine Coronaviruses: Overview of the State of the Art

Hanna Turlewicz-Podbielska et al.

Summary: Coronaviruses exhibit high mutation rates and recombine easily, enabling them to overcome species barriers. Six CoV can infect pigs, with different strains causing various diseases. Control of CoV infections in pigs requires rapid diagnostics and focus on biosecurity.

VIROLOGICA SINICA (2021)

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Article Multidisciplinary Sciences

Potential anti-COVID-19 agents, cepharanthine and nelfinavir, and their usage for combination treatment

Hirofumi Ohashi et al.

Summary: The study identified cepharanthine and nelfinavir as potential antiviral agents against SARS-CoV-2, with different modes of action. A synergistic effect was observed when these two drugs were used in combination, shortening the time until viral clearance. Further evaluation of the anti-SARS-CoV-2 activity of cepharanthine and nelfinavir is warranted.

ISCIENCE (2021)

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Article

Molnupiravir: evidence by press release

James A Cave et al.

Drug and Therapeutics Bulletin (2021)

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Article Virology

Coronavirus Porcine Epidemic Diarrhea Virus Nucleocapsid Protein Interacts with p53 To Induce Cell Cycle Arrest in S-Phase and Promotes Viral Replication

Mingjun Su et al.

Summary: The study revealed that PEDV N protein interacts with p53 to activate the p53-DREAM pathway, inducing S-phase arrest to promote viral replication. Hyperoside, a small molecular compound, can antagonize N protein-induced S-phase arrest and inhibit viral replication by interfering with N protein-p53 interaction. These findings shed new light on PEDV-host interaction and offer a novel antiviral strategy against PEDV.

JOURNAL OF VIROLOGY (2021)

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Article Biochemistry & Molecular Biology

Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis

Florian Kabinger et al.

Summary: Molnupiravir is an oral antiviral drug candidate that increases viral RNA mutations frequency and inhibits replication of SARS-CoV-2 by altering the substrate preference of RdRp. This two-step mutagenesis mechanism can explain the broad-spectrum antiviral activity of molnupiravir, making it a promising COVID-19 treatment option.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2021)

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Article Cell Biology

Protective Effect of Zinc Oxide and Its Association with Neutrophil Degranulation in Piglets Infected with Porcine Epidemic Diarrhea Virus

Qian Zhang et al.

Summary: This study found that Zinc oxide administration can exert antiviral and anti-inflammatory effects on PEDV-infected piglets, improving growth performance, intestinal redox status, morphology, and function, and reducing diarrhea.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Article Virology

Construction of a Recombinant Porcine Epidemic Diarrhea Virus Encoding Nanoluciferase for High-Throughput Screening of Natural Antiviral Products

Wan Li et al.

Summary: Porcine epidemic diarrhea virus (PEDV) is a major cause of acute enteric disease in neonatal piglets, with no approved drugs currently available. A nanoluciferase (NLuc)-based high-throughput screening (HTS) platform was developed to identify anti-PEDV compounds, resulting in the discovery of 25 compounds that significantly inhibit PEDV replication, including 7 natural antioxidants. This study provides a powerful platform for the rapid screening of promising therapeutic compounds against PEDV infection.

VIRUSES-BASEL (2021)

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Article Multidisciplinary Sciences

Search for RNA aptamers against non-structural protein of SARS-CoV-2: Design using molecular dynamics approach

Ram Kothandan et al.

Summary: This study aims to identify stable and effective single strand RNA-based aptamers against NSP10 in SARS-CoV-2. Through computational approach, protein-aptamer docking and molecular dynamics simulation, the study revealed high binding affinity and conformational stability between the aptamers and the protein.

BENI-SUEF UNIVERSITY JOURNAL OF BASIC AND APPLIED SCIENCES (2021)

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Article Critical Care Medicine

Losartan Rescues Inflammation-related Mucociliary Dysfunction in Relevant Models of Cystic Fibrosis

Michael D. Kim et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2020)

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Article Biochemistry & Molecular Biology

Learning from the Past: Possible Urgent Prevention and Treatment Options for Severe Acute Respiratory Infections Caused by 2019-nCoV

Jared S. Morse et al.

CHEMBIOCHEM (2020)

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Review Virology

Coronavirus infections and immune responses

Geng Li et al.

JOURNAL OF MEDICAL VIROLOGY (2020)

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Article Biochemistry & Molecular Biology

Carbazole Alkaloids from Clausena anisum-olens: Isolation, Characterization, and Anti-HIV Evaluation

Jing-Hua Yang et al.

MOLECULES (2020)

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Article Multidisciplinary Sciences

A pneumonia outbreak associated with a new coronavirus of probable bat origin

Peng Zhou et al.

NATURE (2020)

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Article Virology

Antiviral Effect of Epigallocatechin Gallate via Impairing Porcine Circovirus Type 2 Attachment to Host Cell Receptor

Jiarong Li et al.

VIRUSES-BASEL (2020)

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Review Virology

Understanding SARS-CoV-2-Mediated Inflammatory Responses: From Mechanisms to Potential Therapeutic Tools

Yajing Fu et al.

VIROLOGICA SINICA (2020)

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Article Medicine, General & Internal

Repurposing of clinically approved drugs for treatment of coronavirus disease 2019 in a 2019-novel coronavirus-related coronavirus model

Hua-Hao Fan et al.

CHINESE MEDICAL JOURNAL (2020)

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Article Infectious Diseases

New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19?

Christian A. Devaux et al.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2020)

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Article Immunology

Quantitative Proteomic Analysis Reveals Antiviral and Anti-inflammatory Effects of Puerarin in Piglets Infected With Porcine Epidemic Diarrhea Virus

Mengjun Wu et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Review Medicine, General & Internal

Hydroxychloroquine and COVID-19

Neeraj Sinha et al.

POSTGRADUATE MEDICAL JOURNAL (2020)

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Article Multidisciplinary Sciences

Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV

Xiuyuan Ou et al.

NATURE COMMUNICATIONS (2020)

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Review Pharmacology & Pharmacy

The Role of Chloroquine and Hydroxychloroquine in Immune Regulation and Diseases

Gricelis P. Martinez et al.

CURRENT PHARMACEUTICAL DESIGN (2020)

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Article Chemistry, Medicinal

Anti-SARS-CoV-2 Potential of Artemisinins In Vitro

Ruiyuan Cao et al.

ACS INFECTIOUS DISEASES (2020)

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Review Biochemistry & Molecular Biology

The molecular virology of coronaviruses

Ella Hartenian et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2020)

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Article Medicine, General & Internal

Cardiac Involvement of COVID-19: A Comprehensive Review

Wei-Ting Chang et al.

AMERICAN JOURNAL OF THE MEDICAL SCIENCES (2020)

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Article Immunology

Identification and characterization of virulence-attenuated mutants in Ralstonia solanacearum as potential biocontrol agents against bacterial wilt of Pogostemon cablin

Yuyao Zhang et al.

MICROBIAL PATHOGENESIS (2020)

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Review Pharmacology & Pharmacy

Cepharanthine: a review of the antiviral potential of a Japanese-approved alopecia drug in COVID-19

Moshe Rogosnitzky et al.

PHARMACOLOGICAL REPORTS (2020)

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Article Pharmacology & Pharmacy

Tomatidine protects against ischemic neuronal injury by improving lysosomal function

Anil Ahsan et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2020)

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Article Immunology

Casticin suppresses monoiodoacetic acid-induced knee osteoarthritis through inhibiting HIF-1α/NLRP3 inflammasome signaling

Xiaochen Li et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2020)

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Article Plant Sciences

Antiviral activity against porcine epidemic diarrhea virus of Pogostemon cablin polysaccharide

Yun Chen et al.

JOURNAL OF ETHNOPHARMACOLOGY (2020)

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Review Pharmacology & Pharmacy

Drug repurposing approach to fight COVID-19

Thakur Uttam Singh et al.

PHARMACOLOGICAL REPORTS (2020)

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Article Microbiology

Aloe extract inhibits porcine epidemic diarrhea virus in vitro and in vivo

Zhichao Xu et al.

VETERINARY MICROBIOLOGY (2020)

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Review Immunology

Comparative Review of SARS-CoV-2, SARS-CoV, MERS-CoV, and Influenza A Respiratory Viruses

Zeinab Abdelrahman et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Immunology

Ad26 vector-based COVID-19 vaccine encoding a prefusion-stabilized SARS-CoV-2 Spike immunogen induces potent humoral and cellular immune responses

Rinke Bos et al.

NPJ VACCINES (2020)

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Editorial Material Medicine, General & Internal

FDA Approval of Remdesivir - A Step in the Right Direction

Daniel Rubin et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Review Cell Biology

Comprehensive Structural and Molecular Comparison of Spike Proteins of SARS-CoV-2, SARS-CoV and MERS-CoV, and Their Interactions with ACE2

Ma'mon M. Hatmal et al.

CELLS (2020)

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Article Veterinary Sciences

Tomatidine inhibits porcine epidemic diarrhea virus replication by targeting 3CL protease

Pengcheng Wang et al.

VETERINARY RESEARCH (2020)

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Article Biology

Escape from neutralizing antibodies by SARS-CoV-2 spike protein variants

Yiska Weisblum et al.

ELIFE (2020)

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Review Allergy

Perspectives on monoclonal antibody therapy as potential therapeutic intervention for Coronavirus disease-19 (COVID-19)

Balamurugan Shanmugaraj et al.

ASIAN PACIFIC JOURNAL OF ALLERGY AND IMMUNOLOGY (2020)

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Article Integrative & Complementary Medicine

Effect of Puerarin, Baicalin and Berberine Hydrochloride on the Regulation of IPEC-J2 Cells Infected with Enterotoxigenic Escherichia coli

Xiaoxi Liu et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2019)

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Article Biochemical Research Methods

Serum Exosomes from Newborn Piglets Restrict Porcine Epidemic Diarrhea Virus Infection

Jianing Chen et al.

JOURNAL OF PROTEOME RESEARCH (2019)

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Review Virology

Coronavirus envelope protein: current knowledge

Dewald Schoeman et al.

VIROLOGY JOURNAL (2019)

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Article Genetics & Heredity

MicroRNAs Mediated Regulation of Expression of Nucleoside Analog Pathway Genes in Acute Myeloid Leukemia

Neha S. Bhise et al.

GENES (2019)

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Article Surgery

The Pathogenesis and Treatment of the Stiff Finger

Eric D. Wang et al.

CLINICS IN PLASTIC SURGERY (2019)

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Article Multidisciplinary Sciences

Synthetic surfactin analogues have improved anti-PEDV properties

Lvfeng Yuan et al.

PLOS ONE (2019)

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Article Pharmacology & Pharmacy

Broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase

Ariane J. Brown et al.

ANTIVIRAL RESEARCH (2019)

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Review Chemistry, Medicinal

Medicinal prospects of antioxidants: A review

Kumari Neha et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)

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Review Biochemistry & Molecular Biology

Reviewing HIV-1 Gag Mutations in Protease Inhibitors Resistance: Insights for Possible Novel Gag Inhibitor Designs

Chinh Tran-To Su et al.

MOLECULES (2019)

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Article Infectious Diseases

Spiramycin and azithromycin, safe for administration to children, exert antiviral activity against enterovirus A71 in vitro and in vivo

Shinuan Zeng et al.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2019)

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Article Genetics & Heredity

In vitro antiviral activity of Griffithsin against porcine epidemic diarrhea virus

Lan Li et al.

VIRUS GENES (2019)

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Article Nutrition & Dietetics

Oral supplementation with liposomal glutathione elevates body stores of glutathione and markers of immune function

R. Sinha et al.

EUROPEAN JOURNAL OF CLINICAL NUTRITION (2018)

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Article Immunology

Attenuation of inflammatory pain by puerarin in animal model of inflammation through inhibition of pro-inflammatory mediators

Muhammad Zia Ullah et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2018)

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Article Hematology

Inactivation of chikungunya virus in blood components treated with amotosalen/ultraviolet A light or amustaline/glutathione

Andrew Laughhunn et al.

TRANSFUSION (2018)

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Article Microbiology

Identification of two antiviral inhibitors targeting 3C-like serine/3C-like protease of porcine reproductive and respiratory syndrome virus and porcine epidemic diarrhea virus

Yuejun Shi et al.

VETERINARY MICROBIOLOGY (2018)

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Article Microbiology

Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease

Maria L. Agostini et al.

MBIO (2018)

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Article Pharmacology & Pharmacy

Multiple antiviral approaches of (-)-epigallocatechin-3-gallate (EGCG) against porcine reproductive and respiratory syndrome virus infection in vitro

Mengyun Ge et al.

ANTIVIRAL RESEARCH (2018)

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Article Virology

Potent suppression of HIV-1 cell attachment by Kudzu root extract

S. Mediouni et al.

RETROVIROLOGY (2018)

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Review Pediatrics

Malaria: An Update

Srikanta Basu et al.

INDIAN JOURNAL OF PEDIATRICS (2017)

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Article Biochemistry & Molecular Biology

Calcitonin protects chondrocytes from lipopolysaccharide-induced apoptosis and inflammatory response through MAPK/Wnt/NF-κB pathways

Lai-Bo Zhang et al.

MOLECULAR IMMUNOLOGY (2017)

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Review Pharmacology & Pharmacy

Unpacking 'Artemisinin Resistance'

Jigang Wang et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2017)

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Article Microbiology

Vaccines for porcine epidemic diarrhea virus and other swine coronaviruses

Volker Gerdts et al.

VETERINARY MICROBIOLOGY (2017)

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Review Nutrition & Dietetics

Zinc as a Gatekeeper of Immune Function

Inga Wessels et al.

NUTRIENTS (2017)

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Article Oncology

The dominant role of proofreading exonuclease activity of replicative polymerase ε in cellular tolerance to cytarabine (Ara-C)

Masataka Tsuda et al.

ONCOTARGET (2017)

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Article Microbiology

Arsenite-induced stress granule formation is inhibited by elevated levels of reduced glutathione in West Nile virus-infected cells

Mausumi Basu et al.

PLOS PATHOGENS (2017)

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Article Biochemistry & Molecular Biology

Xanthohumol ameliorates lipopolysaccharide (LPS)-induced acute lung injury via induction of AMPK/GSK3β-Nrf2 signal axis

Hongming Lv et al.

REDOX BIOLOGY (2017)

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Review Pharmacology & Pharmacy

Zinc oxide nanoparticles: a promising nanomaterial for biomedical applications

Pawan K. Mishra et al.

DRUG DISCOVERY TODAY (2017)

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Article Chemistry, Medicinal

Therapeutic Potential of Steroidal Alkaloids in Cancer and Other Diseases

Qi-Wei Jiang et al.

MEDICINAL RESEARCH REVIEWS (2016)

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Middle East respiratory syndrome coronavirus infection is inhibited by griffithsin

Jean K. Millet et al.

ANTIVIRAL RESEARCH (2016)

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Article Chemistry, Multidisciplinary

Polyphenolic glycosides isolated from Pogostemon cablin (Blanco) Benth. as novel influenza neuraminidase inhibitors

Fang Liu et al.

CHEMISTRY CENTRAL JOURNAL (2016)

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Review Pharmacology & Pharmacy

Naphthoquine: An Emerging Candidate for Artemisinin Combination Therapy

Brioni R. Moore et al.

DRUGS (2016)

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Article Chemistry, Medicinal

Alkaloids from the Sponge Stylissa carteri Present Prospective Scaffolds for the Inhibition of Human Immunodeficiency Virus 1 (HIV-1)

Aubrie O'Rourke et al.

MARINE DRUGS (2016)

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Review Cell Biology

Antioxidant Intake and Antitumor Therapy: Toward Nutritional Recommendations for Optimal Results

Nuria Mut-Salud et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2016)

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Article Virology

Griffithsin binds to the glycosylated proteins (E and prM) of Japanese encephalitis virus and inhibit its infection

Hassan Z. A. Ishag et al.

VIRUS RESEARCH (2016)

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Review Virology

Structure, Function, and Evolution of Coronavirus Spike Proteins

Fang Li

ANNUAL REVIEW OF VIROLOGY, VOL 3 (2016)

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Article Microbiology

Griffithsin and Carrageenan Combination To Target Herpes Simplex Virus 2 and Human Papillomavirus

Keith Levendosky et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2015)

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Article Pharmacology & Pharmacy

A screen of the NIH Clinical Collection small molecule library identifies potential anti-coronavirus drugs

Jianzhong Cao et al.

ANTIVIRAL RESEARCH (2015)

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Article Biotechnology & Applied Microbiology

Improving the large scale purification of the HIV microbicide, griffithsin

Joshua L. Fuqua et al.

BMC BIOTECHNOLOGY (2015)

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Article Plant Sciences

Antiviral Matrine-Type Alkaloids from the Rhizomes of Sophora tonkinensis

Qi-Ming Pan et al.

JOURNAL OF NATURAL PRODUCTS (2015)

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Article Virology

Coronavirus envelope (E) protein remains at the site of assembly

Pavithra Venkatagopalan et al.

VIROLOGY (2015)

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Review Virology

Functions of the 5′- and 3′-untranslated regions of tobamovirus RNA

Tetsuya Chujo et al.

VIRUS RESEARCH (2015)

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Inferring the hosts of coronavirus using dual statistical models based on nucleotide composition

Qin Tang et al.

SCIENTIFIC REPORTS (2015)

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Antiviral activity of aloe-emodin against influenza A virus via galectin-3 up-regulation

Shih-Wen Li et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2014)

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Article Virology

Griffithsin inhibits Japanese encephalitis virus infection in vitro and in vivo

Hassan Z. A. Ishag et al.

ARCHIVES OF VIROLOGY (2013)

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Review Chemistry, Medicinal

Recent development on naphthoquinone derivatives and their therapeutic applications as anticancer agents

Vishnu Kumar Tandon et al.

EXPERT OPINION ON THERAPEUTIC PATENTS (2013)

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Article Virology

Griffithsin Protects Mice from Genital Herpes by Preventing Cell-to-Cell Spread

Briana Nixon et al.

JOURNAL OF VIROLOGY (2013)

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Article Medicine, Research & Experimental

Water extract of Pueraria lobata Ohwi has anti-viral activity against human respiratory syncytial virus in human respiratory tract cell lines

Tzeng-Jih Lin et al.

KAOHSIUNG JOURNAL OF MEDICAL SCIENCES (2013)

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Article Multidisciplinary Sciences

Antiviral Lectins from Red and Blue-Green Algae Show Potent In Vitro and In Vivo Activity against Hepatitis C Virus

Yutaka Takebe et al.

PLOS ONE (2013)

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Article Multidisciplinary Sciences

Artemisinin Analogues as Potent Inhibitors of In Vitro Hepatitis C Virus Replication

Susan Obeid et al.

PLOS ONE (2013)

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Article Microbiology

Artemisinin-Derived Dimer Diphenyl Phosphate Is an Irreversible Inhibitor of Human Cytomegalovirus Replication

Ran He et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2012)

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Article Pharmacology & Pharmacy

A screen for modulators of large T antigen's ATPase activity uncovers novel inhibitors of Simian Virus 40 and BK virus replication

Sandlin P. Seguin et al.

ANTIVIRAL RESEARCH (2012)

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Article Pharmacology & Pharmacy

Enhanced inhibition of foot-and-mouth disease virus by combinations of porcine interferon-α and antiviral agents

Su-Mi Kim et al.

ANTIVIRAL RESEARCH (2012)

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Review Chemistry, Multidisciplinary

Occurrence, Biogenesis, and Synthesis of Biologically Active Carbazole Alkaloids

Arndt W. Schmidt et al.

CHEMICAL REVIEWS (2012)

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Article Gastroenterology & Hepatology

(-)-Epigallocatechin-3-gallate is a new inhibitor of hepatitis C virus entry

Noemie Calland et al.

HEPATOLOGY (2012)

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Article Immunology

Oral administration of patchouli alcohol isolated from Pogostemonis Herba augments protection against influenza viral infection in mice

Yu-Cui Li et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2012)

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Article Plant Sciences

Puerarin exerts antipyretic effect on lipopolysaccharide-induced fever in rats involving inhibition of pyrogen production from macrophages

Xiu-Juan Yao et al.

JOURNAL OF ETHNOPHARMACOLOGY (2012)

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The first complete genome sequences of clinical isolates of human coronavirus 229E

Seyed Mohammad Jazaeri Farsani et al.

VIRUS GENES (2012)

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Review Virology

The Coronavirus E Protein: Assembly and Beyond

Travis R. Ruch et al.

VIRUSES-BASEL (2012)

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Review Oncology

Green Tea Polyphenols as Proteasome Inhibitors: Implication in Chemoprevention

H. Yang et al.

CURRENT CANCER DRUG TARGETS (2011)

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Anti-oxidative and TNF-α suppressive activities of puerarin derivative (4AC) in RAW264.7 cells and collagen-induced arthritic rats

Cheng Xiao et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2011)

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Article Oncology

(-)-Epigallocatechin-3-gallate induces apoptosis in gastric cancer cell lines by down-regulating survivin expression

Chihiro Onoda et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2011)

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Article Oncology

Tea Polyphenols Induce Apoptosis Through Mitochondrial Pathway and by Inhibiting Nuclear Factor-kappa B and Akt Activation in Human Cervical Cancer Cells

Madhulika Singh et al.

ONCOLOGY RESEARCH (2011)

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Article Virology

Subcellular location and topology of severe acute respiratory syndrome coronavirus envelope protein

Jose L. Nieto-Torres et al.

VIROLOGY (2011)

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Article Integrative & Complementary Medicine

Antioxidative and Antiviral Properties of Flowering Cherry Fruits (Prunus serrulata L. var. spontanea)

Hong-Sun Yook et al.

AMERICAN JOURNAL OF CHINESE MEDICINE (2010)

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Article Pharmacology & Pharmacy

Puerarin Inhibits C-Reactive Protein Expression via Suppression of Nuclear Factor κB Activation in Lipopolysaccharide-Induced Peripheral Blood Mononuclear Cells of Patients with Stable Angina Pectoris

Xiangjun Yang et al.

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2010)

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Article Virology

In vitro anti-viral activity of the total alkaloids from Tripterygium hypoglaucum against herpes simplex virus type 1

Zhe Ren et al.

VIROLOGICA SINICA (2010)

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Review Chemistry, Multidisciplinary

Natural products as promising drug candidates for the treatment of hepatitis B and C

Carolin Wohlfarth et al.

ACTA PHARMACOLOGICA SINICA (2009)

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Article Pharmacology & Pharmacy

Antiviral activity of quercetin 7-rhamnoside against porcine epidemic diarrhea virus

Hwa-Jung Choi et al.

ANTIVIRAL RESEARCH (2009)

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Article Chemistry, Medicinal

Design and efficient synthesis of novel arylthiourea derivatives as potent hepatitis C virus inhibitors

Iou-Jiun Kang et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)

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Article Cell Biology

SARS coronavirus entry into host cells through a novel clathrin- and caveolae-independent endocytic pathway

Hongliang Wang et al.

CELL RESEARCH (2008)

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Article Biochemistry & Molecular Biology

Tomatidine inhibits iNOS and COX-2 through suppression of NF-κB and JNK pathways in LPS-stimulated mouse macrophages

Feng-Lan Chiu et al.

FEBS LETTERS (2008)

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Article Agriculture, Multidisciplinary

Antioxidant properties of sour cherries (Prunus cerasus L.):: Role of colorless phytochemicals from the methanolic extract of ripe fruits

Simona Piccolella et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2008)

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Article Virology

In vitro inhibition of coronavirus replications by the traditionally used medicinal herbal extracts, Cimicifuga rhizoma, Meliae cortex, Coptidis rhizoma, and Phellodendron cortex

Hye-Young Kim et al.

JOURNAL OF CLINICAL VIROLOGY (2008)

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Review Public, Environmental & Occupational Health

Artemisinin-based combination treatment of falciparum malaria

Francois Nosten et al.

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE (2007)

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Multiplicity of carbohydrate-binding sites in β-prism fold lectins:: occurrence and possible evolutionary implications

Alok Sharma et al.

JOURNAL OF BIOSCIENCES (2007)

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Article Chemistry, Multidisciplinary

Structure and dynamics of surfactin studied by NMR in micellar media

Pascale Tsan et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)

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Article Biochemistry & Molecular Biology

Suppression of influenza A virus nuclear antigen production and neuraminidase activity by a nutrient mixture containing ascorbic acid, green tea extract and amino acids

R. J. Jariwalla et al.

BIOFACTORS (2007)

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Article Biochemistry & Molecular Biology

Domain-swapped structure of the potent antiviral protein griffithsin and its mode of carbohydrate binding

Natasza E. Ziolkowska et al.

STRUCTURE (2006)

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Article Microbiology

Inhibition of human coronavirus NL63 infection at early stages of the replication cycle

Krzysztof Pyrc et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2006)

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Article Pharmacology & Pharmacy

Effect of artemisinin/artesunate as inhibitors of hepatitis B virus production in an in vitro replicative system

MR Romero et al.

ANTIVIRAL RESEARCH (2005)

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Article Virology

Chloroquine is a potent inhibitor of SARS coronavirus infection and spread

Martin J. Vincent et al.

VIROLOGY JOURNAL (2005)

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Article Multidisciplinary Sciences

Small molecules targeting severe acute respiratory syndrome human coronavirus

CY Wu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

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Article Biochemistry & Molecular Biology

Potent inhibition of SARS-associated coronavirus (SCoV) infection and replication by type I interferons (IFN-α/β) but not by type II interferon (IFN-γ)

BJ Zheng et al.

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH (2004)

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Article Multidisciplinary Sciences

Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus

WH Li et al.

NATURE (2003)

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Article Medicine, General & Internal

Treatment of SARS with human interferons

J Cinatl et al.

LANCET (2003)

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Article Medicine, General & Internal

Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus

J Cinatl et al.

LANCET (2003)

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Review Chemistry, Multidisciplinary

Isolation and synthesis of biologically active carbazole alkaloids

HJ Knölker et al.

CHEMICAL REVIEWS (2002)

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Article Immunology

Polyphenolic antioxidant (-)-epigallocatechin-3-gallate from green tea as a candidate anti-HIV agent

G Fassina et al.

AIDS (2002)

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Article Genetics & Heredity

Antiviral activity of artesunate towards wild-type, recombinant, and ganciclovir-resistant human cytomegaloviruses

T Efferth et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2002)

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Article Pharmacology & Pharmacy

Inhibitory effects of (-)-epigallocatechin gallate on the life cycle of human immunodeficiency virus type 1 (HIV-1)

K Yamaguchi et al.

ANTIVIRAL RESEARCH (2002)

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