期刊
MICROORGANISMS
卷 10, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/microorganisms10081500
关键词
biofilm; chronic wounds; colonization; cutaneous microbiota; microbial crosstalk; microbial interactions; virulence
类别
Chronic wounds, affecting millions of patients every year, can be divided into three types and require tissue debridement to reduce biofilm formation. Understanding microbial interactions is crucial for the management of chronic wounds.
Chronic wounds, defined by their resistance to care after four weeks, are a major concern, affecting millions of patients every year. They can be divided into three types of lesions: diabetic foot ulcers (DFU), pressure ulcers (PU), and venous/arterial ulcers. Once established, the classical treatment for chronic wounds includes tissue debridement at regular intervals to decrease biofilm mass constituted by microorganisms physiologically colonizing the wound. This particular niche hosts a dynamic bacterial population constituting the bed of interaction between the various microorganisms. The temporal reshuffle of biofilm relies on an organized architecture. Microbial community turnover is mainly associated with debridement (allowing transitioning from one major representant to another), but also with microbial competition and/or collaboration within wounds. This complex network of species and interactions has the potential, through diversity in antagonist and/or synergistic crosstalk, to accelerate, delay, or worsen wound healing. Understanding these interactions between microorganisms encountered in this clinical situation is essential to improve the management of chronic wounds.
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