Special Issue: Type III Secretion Systems in Human/Animal Pathogenic Bacteria

Review Biochemistry & Molecular Biology

CryoEM of bacterial secretion systems: A primer for microbiologists

Trishant R. Umrekar et al.

Summary: CryoEM has matured, offering valuable structural insights into molecular biology. This technique, through single particle analysis and electron cryotomography and subtomogram averaging, provides microbiologists with the ability to study bacterial secretion systems, particularly focusing on the type III secretion system.

MOLECULAR MICROBIOLOGY (2021)

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Article Microbiology

Single Cell Analysis of Bistable Expression of Pathogenicity Island 1 and the Flagellar Regulon in Salmonella enterica

Maria Antonia Sanchez-Romero et al.

Summary: Bistable expression of Salmonella enterica pathogenicity island 1 (SPI-1) and the flagellar network has independent switching mechanisms, resulting in four subpopulations with varying levels of invasion capability. Expression of the flagellar regulon contributes to the growth impairment in SPI-1(ON) cells, requiring a switch to both SPI-1(OFF) and Flag(OFF) states for growth resumption.

MICROORGANISMS (2021)

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Article Microbiology

Systematic Analysis of the Stress-Induced Genomic Instability of Type Three Secretion System in Aeromonas salmonicida subsp. salmonicida

Pierre-Etienne Marcoux et al.

Summary: European strains of Aeromonas salmonicida subsp. salmonicida are more prone to losing the TTSS locus compared to Canadian strains. A cluster of genes encoding putative proteins with DNA binding capacity and phage proteins was found to be almost perfectly correlated with the susceptibility of different strains to lose the locus. This discovery opens up new opportunities for studying the thermosensitivity of pAsa5.

MICROORGANISMS (2021)

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Article Microbiology

Novel Template Plasmids pCyaA'-Kan and pCyaA'-Cam for Generation of Unmarked Chromosomal cyaA' Translational Fusion to T3SS Effectors in Salmonella

Paulina A. Fernandez et al.

Summary: By constructing new plasmids, unmarked chromosomal fusions can be generated in Salmonella for studying the expression, secretion, and translocation of T3SS effectors into eukaryotic cells.

MICROORGANISMS (2021)

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Review Microbiology

The Shigella Type III Secretion System: An Overview from Top to Bottom

Meenakumari Muthuramalingam et al.

Summary: Shigella, a human-restricted pathogen causing bacillary dysentery, primarily relies on a type III secretion system (T3SS) consisting of multiple components and proteins for its virulence. Studying the T3SS injectisome in Shigella and related systems helps to understand its pathogenic mechanisms and develop prevention strategies.

MICROORGANISMS (2021)

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Review Microbiology