4.6 Article

Contaminated Incubators: Source of a Multispecies Enterobacter Outbreak of Neonatal Sepsis

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Infectious Diseases

Uncovering the novel Enterobacter cloacae complex species responsible for septic shock deaths in newborns: a cohort study

Delphine Girlich et al.

Summary: This study analyzed the transmission routes of Enterobacter cloacae complex isolates in a neonatal intensive care unit using whole genome sequencing, revealing the impact of E cloacae on fatal septic shocks in neonates and the role of incubators as long-term reservoirs and sources of cross contamination.

LANCET MICROBE (2021)

Article Public, Environmental & Occupational Health

Enterobacter cloacae complex outbreak in a neonatal intensive care unit: multifaceted investigations and preventive measures are needed

A. Rahal et al.

Summary: The report discusses the investigation of an Enterobacter cloacae complex outbreak in a neonatal intensive care unit from November 2020 to February 2021. Pulsed-field gel electrophoresis revealed that five out of eight cases were infected with a clonal strain, potentially due to the shared breast pumps among mothers in the unit. Copyright 2021 The Healthcare Infection Society. Published by Elsevier Ltd.

JOURNAL OF HOSPITAL INFECTION (2021)

Article Pediatrics

Persistent microbial contamination of incubators despite disinfection

Marie Chavignon et al.

Summary: This study revealed that pathogenic contaminants persist on incubators despite disinfection, posing a risk for subsequent infection in preterm neonates. Further research is needed to explore mechanisms of bacterial persistence and ways to combat environmental colonisation in order to control nosocomial infections in NICUs.

PEDIATRIC RESEARCH (2021)

Article Microbiology

dnaJ: a New Approach to Identify Species within the Genus Enterobacter

Enrique Hernandez-Alonso et al.

Summary: A new PCR and amplicon sequencing technique based on the dnaJ gene was proposed for more accurate species identification of Enterobacter. The method was validated by comparing type strains, sequences from GenBank, and clinical specimens, showing high identification accuracy. This approach offers a quicker and more economical method for identifying Enterobacter species in clinical settings.

MICROBIOLOGY SPECTRUM (2021)

Article Microbiology

Genomic Investigation and Successful Containment of an Intermittent Common Source Outbreak of OXA-48-Producing Enterobacter cloacae Related to Hospital Shower Drains

Dennis Nurjadi et al.

Summary: The hospital water environment can serve as a reservoir for multiward outbreaks, leading to acquisitions or transmissions of multidrug-resistant organisms in a hospital setting. Most Gram-negative bacteria have the ability to form biofilms and persist in hospital plumbing systems for extended periods. Eliminating these reservoirs is crucial to preventing further transmission, but proposed decontamination regimens, such as using acetic acid, can only suppress rather than fully eliminate the environmental reservoir. This study demonstrated that colonization with multidrug-resistant organisms can be acquired through showering in showers with contaminated water traps and drains.

MICROBIOLOGY SPECTRUM (2021)

Article Multidisciplinary Sciences

Presence of 2-hydroxymyristate on endotoxins is associated with death in neonates with Enterobacter cloacae complex septic shock

Luis A. Augusto et al.

Summary: The study found that Enterobacter cloacae strains carry diverse molecular species of lipid A, with virulence correlated to the presence of 2-hydroxymyristic acid as a secondary substituent. This is the first evidence linking LPS structural moiety to neonatal sepsis outcome, suggesting the use of this fatty acid marker as a detection tool for high-risk patients to reduce mortality.

ISCIENCE (2021)

Article Obstetrics & Gynecology

Disparities in Health Care-Associated Infections in the NICU

Jessica Liu et al.

AMERICAN JOURNAL OF PERINATOLOGY (2020)

Article Immunology

2-Hydroxylation of Acinetobacter baumannii Lipid A Contributes to Virulence

Toby L. Bartholomew et al.

INFECTION AND IMMUNITY (2019)

Review Microbiology

Enterobacter spp.: Update on Taxonomy, Clinical Aspect, and Emerging Antimicrobial Resistance

Anne Davin-Regli et al.

CLINICAL MICROBIOLOGY REVIEWS (2019)

Article Immunology

Overestimation of an Outbreak of Enterobacter cloacae in a Neonatal Intensive Care Unit in Germany, 2015

Gyde Steffen et al.

PEDIATRIC INFECTIOUS DISEASE JOURNAL (2019)

Article Multidisciplinary Sciences

Enterobacter bugandensis: a novel enterobacterial species associated with severe clinical infection

Niladri Bhusan Pati et al.

SCIENTIFIC REPORTS (2018)

Review Public, Environmental & Occupational Health

Effectiveness of healthcare worker screening in hospital outbreaks with gram-negative pathogens: a systematic review

Nikos Ulrich et al.

ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL (2018)

Article Biochemistry & Molecular Biology

ABySS 2.0: resource-efficient assembly of large genomes using a Bloom filter

Shaun D. Jackman et al.

GENOME RESEARCH (2017)

Article Microbiology

Enterobacter bugandensis sp nov., isolated from neonatal blood

Swapnil Doijad et al.

INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY (2016)

Article Biochemical Research Methods

Roary: rapid large-scale prokaryote pan genome analysis

Andrew J. Page et al.

BIOINFORMATICS (2015)

Review Pediatrics

Late-onset neonatal sepsis: recent developments

Ying Dong et al.

ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION (2015)

Review Obstetrics & Gynecology

Healthcare-associated infections in the hospitalized neonate: a review

Thomas A. Hooven et al.

EARLY HUMAN DEVELOPMENT (2014)

Article Public, Environmental & Occupational Health

Healthcare associated infections (HAI) perspectives

Jaffar A. Al-Tawfiq et al.

JOURNAL OF INFECTION AND PUBLIC HEALTH (2014)

Article Multidisciplinary Sciences

Virulence and stress-related periplasmic protein (VisP) in bacterial/host associations

Cristiano G. Moreira et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Review Microbiology

Enterobacter cloacae complex: clinical impact and emerging antibiotic resistance

Maria Lina Mezzatesta et al.

FUTURE MICROBIOLOGY (2012)

Article Infectious Diseases

Outbreak of a novel Enterobacter sp carrying blaCTX-M-15 in a neonatal unit of a tertiary care hospital in Tanzania

Stephen E. Mshana et al.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2011)

Article Multidisciplinary Sciences

FastTree 2-Approximately Maximum-Likelihood Trees for Large Alignments

Morgan N. Price et al.

PLOS ONE (2010)

Review Public, Environmental & Occupational Health

Investigation of an outbreak of Enterobacter cloacae in a neonatal unit and review of the literature

M. Dalben et al.

JOURNAL OF HOSPITAL INFECTION (2008)

Article Public, Environmental & Occupational Health

Health care-associated infections in the neonatal intensive care unit

MT Brady

AMERICAN JOURNAL OF INFECTION CONTROL (2005)

Article Public, Environmental & Occupational Health

Molecular epidemiology of systemic infection caused by Enterobacter cloacae in a high-risk neonatal intensive care unit

RH Kuboyama et al.

INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY (2003)

Article Public, Environmental & Occupational Health

Enterobacter cloacae sepsis outbreak in a newborn unit caused by contaminated total parenteral nutrition solution

AT Tresoldi et al.

AMERICAN JOURNAL OF INFECTION CONTROL (2000)

Article Medicine, General & Internal

An antibiotic policy to prevent emergence of resistant bacilli

P de Man et al.

LANCET (2000)