期刊
ANTIOXIDANTS
卷 11, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/antiox11081560
关键词
ageing; pine bark; proanthocyanidins; antioxidants; polyphenols; oxidative stress
资金
- Tismor Health and Wellness [G2000808]
- Hunter Medical Research Institute [G2101041]
This study investigated the antioxidant effects of a polyphenol-rich dietary supplement containing Pinus massoniana bark extract (PMBE) in healthy older adults. The results showed that PMBE significantly reduced fasting plasma malondialdehyde (MDA) concentrations and had an impact on fibrinogen and interleukin-6 levels. Further research is needed to explore the antioxidant capacity of PMBE in conditions with heightened oxidative stress.
Oxidative stress is a key physiological phenomenon underpinning the ageing process and plays a major developmental role in age-associated chronic diseases. This study investigated the antioxidant effects of a polyphenol-rich dietary supplement containing Pinus massoniana bark extract (PMBE) in healthy older adults. In a double-blinded, placebo-controlled clinical trial, participants were randomised (in a 1:1 ratio) to receive a 50 mL/day dietary supplement containing placebo (0 mg PMBE) or PMBE (1322 mg PMBE) for 12 weeks. The primary outcome was fasting plasma malondialdehyde (MDA) concentrations and secondary outcomes were plasma inflammatory markers. MDA concentrations significantly reduced following PMBE for 6 weeks (-1.19 nmol/mL, 95%CI -1.62, -0.75, p < 0.001) and 12 weeks (-1.35 nmol/mL, 95%CI -1.74, -0.96, p < 0.001) compared to baseline. MDA did not significantly change after the placebo. MDA levels at 6 and 12 weeks were significantly lower following PMBE compared to placebo (p < 0.001). At 12 weeks in the PMBE group, fibrinogen concentrations significantly reduced (-0.25 g/L, 95%CI -0.39, -0.11; p < 0.0001) and interleukin-6 significantly increased compared to placebo (0.30 pg/mL, 95%CI 0.02, 0.59; p < 0.05). PMBE in a polyphenol-rich dietary supplement reduced oxidative stress in healthy older adults. Further studies are warranted to investigate the antioxidant capacity of PMBE in conditions with heightened oxidative stress, such as osteoarthritis, hypertension, type 2 diabetes, or other lifestyle related diseases.
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