期刊
ANTIOXIDANTS
卷 11, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/antiox11081540
关键词
bioactive compounds; phytochemicals; Mediterranean diet; PREDIMED study; urinary microbial phenolic metabolites; cardiovascular; liquid chromatography; mass spectrometry
资金
- CICYT [AGL2016-75329-R, PID2020-114022RB-I00]
- CIBEROBN Instituto de Salud Carlos III
- ISCIII from the Ministerio de Ciencia, Innovacion y Universidadess, (AEI/FEDER, UE)
- Generalitat de Catalunya (GC) [2017SGR196]
- Spanish Ministry of Science Innovation and Universities [FPU20/02478]
- Generalitat de Catalunya [EM/3345/2020]
- FI-SDUR [EMC/2703/2019]
- [FPU17/00513]
The study found that changes in urinary microbial phenolic metabolites were associated with the risk of developing type 2 diabetes. However, when adjusting for fasting plasma glucose, this association lost statistical significance. Changes in dietary patterns may affect the production of metabolites and alter the gut microbial population.
The intake of polyphenols has been associated with a risk reduction of type 2 diabetes. Nevertheless, to the best of our knowledge, the molecules that might be metabolically active after ingestion are only starting to be investigated regarding this metabolic disease. To investigate the association between one-year changes in urinary microbial phenolic metabolites (MPM) and the incidence of type 2 diabetes, we performed a case-control study using data and samples of the PREDIMED trial including 46 incident type 2 diabetes cases of 172 randomly selected participants. Eight urinary MPMs were quantified in urine by liquid chromatography coupled to mass spectrometry and used to assess their associations with type 2 diabetes risk by multivariable logistic regression models. Compared to participants in the lowest tertile of one-year changes in hydroxybenzoic acid glucuronide, those in the highest tertile had a significantly lowered probability of developing type 2 diabetes (OR [95% CI], 0.39 [0.23-0.64]; p < 0.001 for trend). However, when additionally adjusting for fasting plasma glucose, the statistical significance was lost. Changes in the dietary pattern can increase the concentrations of this compound, derived from many (poly)phenol-rich foods, and might be changing the gut microbial population as well, promoting the production of the metabolite.
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