期刊
ANTIOXIDANTS
卷 11, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/antiox11071231
关键词
anticancer; antimicrobial; antioxidant; organoselenium; redox modulators
资金
- King Faisal University, Al-Ahsa, Saudi Arabia [GRANT345]
Novel organic selenides were synthesized and characterized. Their anticancer, antimicrobial, and antioxidant activities were evaluated, showing selective cytotoxicity against cancer cells, antimicrobial potential comparable to reference drugs, and comparable antioxidant activity to vitamin C.
Novel organic selenides were developed in good yields (up to 91%), and their chemical entities were confirmed by IR, MS, and H-1- and C-13-NMR spectroscopy. Their anticancer and antimicrobial properties were estimated against different human cancer (MCF-7 and HepG2) and healthy (WI-38) cell lines, as well as several microbial strains (Escherichia coli, Staphylococcus aureus, and Candida albicans). Furthermore, the 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2 '-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) bioassays were used for the estimation of the antioxidant activities. Generally, cytotoxicity results were more pronounced against the MCF-7 cells than HepG2 cells. Compound 2-((4-((1-hydroxynaphthalen-2-yl)diazenyl)phenyl)selanyl)-N-phenylacetamide (9) was the most cytotoxic, even more than doxorubicin, with IC50 of 3.27 +/- 0.2 against 4.17 +/- 0.2 mu M and twelve-times more selective, respectively. Interestingly, compound 9 exhibited similar antimicrobial potential to reference antibacterial and antifungal drugs and comparable antioxidant activity to vitamin C. These results point to selective cytotoxicity against MCF-7 cells and interesting antimicrobial and antioxidant properties of some newly synthesized organic selenides, which in turn needs further in vitro studies.
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