期刊
ANTIOXIDANTS
卷 11, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/antiox11071371
关键词
phenothiazine; phenothiazine derivatives; antioxidant activity; free radicals; voltammetry
资金
- RFBR
- Czech Science Foundation [19-53-26001]
- Russian State assignment Science [FSWW-2020-0022]
Phenothiazine and its derivatives were studied for their antioxidant activity, and optimal conditions for manifestation of this activity were found. The research showed that phenothiazine derivatives have potential antioxidant properties, which is important for developing complex preparations with antioxidant activity, including in psychiatric practice.
Phenothiazine and its derivatives have a number of properties that contribute to their wider practical use in the production of biologically active substances, drugs, dyes, etc. Therefore, the synthesis and study of new compounds is of great relevance. The aim of this work was to investigate the antioxidant activity of a number of new phenothiazine derivatives. The patterns of electroreduction of oxygen and its radicals in the presence of phenothiazine derivatives in aqueous ethanol media were studied by voltammetry. The influence of various factors on antioxidant activity was considered by the methods of experiment planning. The optimal conditions for the manifestation of the antioxidant activity of phenothiazine derivatives have been found, which seems to be relevant since it opens up new possibilities for their further use as complex preparations with antioxidant activity, including in psychiatric practice.
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