4.7 Review

Antioxidant Therapy in Cancer: Rationale and Progress

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Chemistry, Multidisciplinary

Guiding Transition Metal-Doped Hollow Cerium Tandem Nanozymes with Elaborately Regulated Multi-Enzymatic Activities for Intensive Chemodynamic Therapy

Shuming Dong et al.

Summary: The authors developed a hollow mesoporous Mn/Zr-co-doped CeO2 tandem nanozyme (PHMZCO-AT) with regulated multi-enzymatic activities to disrupt the H2O2 homeostasis, achieve intensive NCDT, and induce tumor apoptosis and death. The nanozyme catalyzes the conversion of superoxide anion into H2O2 in the tumor region and inhibits the off-target decomposition of H2O2. The elevated H2O2 is then converted into toxic hydroxyl radicals, leading to tumor cell death.

ADVANCED MATERIALS (2022)

Article Cell Biology

Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology

Helmut Sies et al.

Summary: This article discusses the key issues associated with identifying the physiological roles of oxidants, with a focus on H2O2 and O-2(.-). The article emphasizes the need for more precise measurement of oxidants and specific identification of their signaling targets. It also highlights the importance of inter-organellar communication and the contribution of environmental exposures. Development of tools for real-time detection and quantification of individual oxidants is crucial for achieving these goals.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2022)

Article Biochemistry & Molecular Biology

Persistence of improved glucose homeostasis in Gclm null mice with age and cadmium treatment

Christopher M. Schaupp et al.

Summary: Antioxidant signaling is a crucial cellular defense pathway, and its importance in aging has been well-documented. This study investigated the effect of aging on the favorable phenotypes observed in young Gclm null mice, including increased antioxidant activity and improved glucose homeostasis. The results showed that these phenotypes persisted into old age and were associated with transcriptional activation of the Nrf2, AMPK, and PPAR gamma pathways.

REDOX BIOLOGY (2022)

Article Gastroenterology & Hepatology

PHLDB2 Mediates Cetuximab Resistance via Interacting With EGFR in Latent Metastasis of Colorectal Cancer

Maochao Luo et al.

Summary: This study identifies PHLDB2 as a key player in latent liver metastasis of colorectal cancer (CRC). Chemotherapeutic-induced oxidative stress promotes N6-methyladenosine modification of PHLDB2 messenger RNA, leading to increased protein expression of PHLDB2. Upregulated PHLDB2 stabilizes EGFR and promotes its nuclear translocation, resulting in activation of EGFR signaling and resistance to cetuximab. The study proposes PHLDB2 as a potential target for CRC treatment.

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY (2022)

Review Biochemistry & Molecular Biology

Ferroptosis at the intersection of lipid metabolism and cellular signaling

Deguang Liang et al.

Summary: This review provides a comprehensive analysis of the mechanisms and signaling pathways involved in ferroptosis, focusing on the impact of lipid metabolism and the potential for therapeutic strategies targeting this interaction.

MOLECULAR CELL (2022)

Review Biochemistry & Molecular Biology

The Double-Edged Sword of Oxidative Stress in Skin Damage and Melanoma: From Physiopathology to Therapeutical Approaches

Monica Emanuelli et al.

Summary: The skin is constantly exposed to reactive oxygen species (ROS) and oxidative stress may play a role in skin diseases, including melanoma. Melanocytes are more susceptible to oxidative stress due to their melanin production process.

ANTIOXIDANTS (2022)

Review Biochemistry & Molecular Biology

Role of NRF2 in Ovarian Cancer

Giovanni Tossetta et al.

Summary: This review summarizes the role of NRF2 in ovarian cancer, focusing on its function in drug resistance, natural and synthetic modulators of NRF2, and its protective function in normal ovarian preservation.

ANTIOXIDANTS (2022)

Article Biochemistry & Molecular Biology

Mitochondrial Reactive Oxygen Species and Mitophagy: A Complex and Nuanced Relationship

James H. Schofield et al.

Summary: The relationship between mitophagy and ROS production is complex and not fully understood. This review discusses mtROS generation and their detrimental effects on cellular viability, along with the cellular defense mechanisms against oxidative stress. Furthermore, the prominent mechanisms governing mitophagy induction that bear on oxidative stress are explored.

ANTIOXIDANTS & REDOX SIGNALING (2021)

Article Oncology

Targeting MARCO and IL37R on Immunosuppressive Macrophages in Lung Cancer Blocks Regulatory T Cells and Supports Cytotoxic Lymphocyte Function

Linnea La Fleur et al.

Summary: The research revealed the correlation between MARCO-expressing TAMs and poor clinical outcomes in patients with non-small cell lung cancer. These TAMs block the antitumor activities of NK cells and T cells, and gain an immune-suppressive phenotype through the release of IL37. Targeting MARCO or IL37R may remodel the immune-suppressive microenvironment in lung cancer patients.

CANCER RESEARCH (2021)

Article Oncology

MYCN-Amplified Neuroblastoma Is Addicted to Iron and Vulnerable to Inhibition of the System Xc-/Glutathione Axis

Konstantinos Floros et al.

Summary: The study uncovers a therapeutic vulnerability in neuroblastoma, where amplified MYCN rewires the cell to increase iron influx and reliance on the Xc-/GSH pathway, leading to susceptibility to ROS-inducing drugs. FDA-approved rheumatoid arthritis drugs SAS and auranofin show antitumor activity in patient-derived xenograft models of MYCN-amplified neuroblastoma. This highlights a potential treatment strategy for this aggressive pediatric cancer.

CANCER RESEARCH (2021)

Article Biochemistry & Molecular Biology

Energy substrate metabolism and mitochondrial oxidative stress in cardiac ischemia/reperfusion injury

Maija Dambrova et al.

Summary: The heart is highly flexible in its metabolism and mitochondria play a crucial role in oxidative phosphorylation and heart function. ROS production pathways during ischemia/reperfusion involve glucose, fatty acids, and the Krebs cycle, with strategies available to modulate substrate accumulation for ROS production mitigation.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

Article Biochemistry & Molecular Biology

Glutathione reductase deficiency alters lung development and hyperoxic responses in neonatal mice

Mary E. Robbins et al.

Summary: Cellular antioxidants protect against hyperoxic lung injury. The role of the glutathione (GSH) system in lung development and bronchopulmonary dysplasia (BPD) pathogenesis has not been systematically investigated. The current study utilized GSH reductase-deficient (Gsr-KO) neonatal mice to test the hypothesis that early disruption of the GSH system negatively impacts lung development and hyperoxic responses. Overall, our data in Gsr-KO mice implicate the GSH system as a key regulator of lung development, cellular differentiation, and hyperoxic responses in neonatal mice.

REDOX BIOLOGY (2021)

Article Oncology

The Hydroxyquinoline Analogue YUM70 Inhibits GRP78 to Induce ER Stress-Mediated Apoptosis in Pancreatic Cancer

Soma Samanta et al.

Summary: GRP78 is a key regulator of ER stress signaling, and YUM70, a novel inhibitor targeting GRP78, induces ER stress-mediated apoptosis in pancreatic cancer cells with in vivo efficacy and synergistic cytotoxicity when combined with topoisomerase and HDAC inhibitors.

CANCER RESEARCH (2021)

Article Biochemistry & Molecular Biology

Modifying the resolving cysteine affects the structure and hydrogen peroxide reactivity of peroxiredoxin 2

Alexander Peskin et al.

Summary: This study investigated the impact of structural changes around the C172 site in Prdx2 protein on H2O2 reactivity, revealing that mutations to C172D and C172W significantly decreased oxidation and hyperoxidation rates. Structural analyses and protein studies showed that the C172S mutation resulted in a more flexible and weaker decamer structure, compared to the wild type.

JOURNAL OF BIOLOGICAL CHEMISTRY (2021)

Review Pharmacology & Pharmacy

The mechanism of action of N-acetylcysteine (NAC): The emerging role of H2S and sulfane sulfur species

Brandan Pedre et al.

Summary: Originally used as a mucolytic, N-acetylcysteine (NAC) is now a standard treatment for paracetamol poisoning and a widely used antioxidant. In addition to its traditional mechanisms, a newly discovered mechanism involves the conversion of NAC into hydrogen sulfide and sulfane sulfur species, which may explain many of its effects.

PHARMACOLOGY & THERAPEUTICS (2021)

Review Cardiac & Cardiovascular Systems

Endoplasmic reticulum stress and unfolded protein response in cardiovascular diseases

Jun Ren et al.

Summary: This review summarizes the role of endoplasmic reticulum stress and protein response in cardiovascular diseases, discussing potential therapeutic strategies for restoring ER proteostasis.

NATURE REVIEWS CARDIOLOGY (2021)

Review Cell Biology

Peroxisomes as cellular adaptors to metabolic and environmental stress

Anyuan He et al.

Summary: Peroxisomes play a crucial role in cellular responses to stress by regulating metabolic adaptation and environmental cues. They are dynamic organelles that can modulate proliferation, morphology, and movement within cells, and engage in crosstalk with other organelles.

TRENDS IN CELL BIOLOGY (2021)

Article Cell Biology

Redox-sensitive cyclophilin A elicits chemoresistance through realigning cellular oxidative status in colorectal cancer

Liyuan Peng et al.

Summary: The study identified CypA as a potential therapeutic target for colorectal cancer by reducing oxidative stress and increasing cell survival, particularly in chemoresistant cases. Targeting CypA with cyclosporine A shows promising efficacy in combating chemoresistant CRC.

CELL REPORTS (2021)

Article Cell Biology

Excessive exercise training causes mitochondrial functional impairment and decreases glucose tolerance in healthy volunteers

Mikael Flockhart et al.

Summary: Exercise training positively affects metabolic health, but excess exercise may lead to reduced mitochondrial function and impaired glucose tolerance. Studies have shown that world-class endurance athletes have issues with glucose control compared to matched control groups.

CELL METABOLISM (2021)

Article Multidisciplinary Sciences

Regulation of longevity by depolarization-induced activation of PLC-β-IP3R signaling in neurons

Ching-On Wong et al.

Summary: Mitochondrial ATP production plays a crucial role in regulating neuronal excitability, and the influence of plasma-membrane potential on ATP production is significant. Depolarized neurons can elevate the ATP/ADP ratio through increased PLC-beta-IP3R signaling, but excessive activation of this pathway leads to a shortened lifespan in Drosophila.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Article Cell Biology

Avasopasem manganese synergizes with hypofractionated radiation to ablate tumors through the generation of hydrogen peroxide

Brock J. Sishc et al.

Summary: Avasopasem manganese (AVA) synergizes with radiation to target tumor cells by increasing intracellular hydrogen peroxide concentrations and enhancing killing of cancer cells. This tumoricidal synergy is now being tested in a phase I-II clinical trial in humans, showing promising therapeutic potential.

SCIENCE TRANSLATIONAL MEDICINE (2021)

Article Oncology

The intricacies of NRF2 regulation in cancer

Cody J. Schmidlin et al.

Summary: NRF2 plays a complex role in cancer by regulating genes involved in cell function and survival, and its activation mode determines its effects in cancer. The discovery of pharmacological modulators targeting NRF2 provides potential breakthroughs in cancer treatment.

SEMINARS IN CANCER BIOLOGY (2021)

Article Oncology

Connections between endoplasmic reticulum stress-associated unfolded protein response, mitochondria, and autophagy in arsenic-induced carcinogenesis

Priya Wadgaonkar et al.

Summary: Arsenic exposure through contaminated drinking water is a global health issue affecting over 200 million people worldwide, leading to various cancers. Research has shifted focus from genetic mutations to epigenetics, metabolism, and endoplasmic reticulum stress in cancer development. Arsenic induces cellular stress through oxidative damage, epigenetic changes, and impairment of DNA repair systems, highlighting the importance of understanding the role of ER stress, mitochondrial dysfunction, and autophagy in cancer prevention and treatment.

SEMINARS IN CANCER BIOLOGY (2021)

Review Biochemistry & Molecular Biology

Control of Oxidative Stress in Cancer Chemoresistance: Spotlight on Nrf2 Role

Giuseppina Barrera et al.

Summary: Chemoresistance poses a significant challenge to cancer treatment by affecting the efficacy of conventional and targeted therapies. Metabolic remodeling, particularly the control of redox status, and the upregulation of antioxidant systems contribute to cancer cell survival post-therapy. The master regulator Nrf2, along with other transcription factors, plays crucial roles in maintaining high antioxidant levels in chemoresistant cancer cells.

ANTIOXIDANTS (2021)

Article Biochemistry & Molecular Biology

Oxidative Post-Translational Modifications: A Focus on Cysteine S-Sulfhydration and the Regulation of Endothelial Fitness

Sofia-Iris Bibli et al.

Summary: This article discusses the impact of changes in oxidative balance on cellular physiology and adaptation, with a focus on the sensitivity of endothelial cells to reactive oxygen species and the role of oxidative modifications in regulating protein function. Persulfidation, a newly identified reversible oxidation modification, plays a crucial role in maintaining cellular redox homeostasis.

ANTIOXIDANTS & REDOX SIGNALING (2021)

Article Biochemistry & Molecular Biology

NNT mediates redox-dependent pigmentation via a UVB- and MITF-independent mechanism

Jennifer Allouche et al.

Summary: This study reveals a mechanism of skin pigmentation that is independent of UV light and MITF, involving the regulation of melanosome maturation through targeting the mitochondrial enzyme NNT. Inhibition of NNT leads to increased pigmentation, as shown in human skin and mice experiments, and genetic modifications of NNT affect melanocytic pigmentation in zebrafish. Analysis of human cohorts also suggests significant associations between skin color and various single-nucleotide polymorphisms within NNT.
Review Biochemistry & Molecular Biology

Release of redox enzymes and micro-RNAs in extracellular vesicles, during infection and inflammation

Stefano Caserta et al.

Summary: Redox enzymes, such as thioredoxin and peroxiredoxin, have been found to act as soluble mediators in immunity by being released from cells. Peroxiredoxins, in particular, can be secreted via exosome-release route but the exact mechanism and reasons behind this process remain unclear. This review discusses the potential redox states of protein cysteines and the role of redox enzymes in their regulation, as well as the studies on the extracellular forms of these enzymes and their association with exosomes/extracellular vesicles in infection and inflammation.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

Article Biochemistry & Molecular Biology

Oxidative bursts of single mitochondria mediate retrograde signaling toward the ER

David M. Booth et al.

Summary: The study shows that individual mitochondria generate oxidative bursts at interorganellar contact sites, with Ca2+ channels directly sensing these bursts and responding with transient Ca2+ transients. Under mitochondrial stress or apoptotic stimuli, the frequency and amplitude of the oxidative bursts can be increased.

MOLECULAR CELL (2021)

Review Biotechnology & Applied Microbiology

Targeting oxidative stress in disease: promise and limitations of antioxidant therapy

Henry Jay Forman et al.

Summary: Oxidative stress plays a role in various diseases, and understanding the mechanisms behind antioxidants and how to enhance antioxidant defences may lead to greater pharmacological success.

NATURE REVIEWS DRUG DISCOVERY (2021)

Article Oncology

Arsenite impinges on endoplasmic reticulum-mitochondria crosstalk to elicit mitochondrial ROS formation and downstream toxicity

Orazio Cantoni et al.

Summary: Arsenite, an important carcinogen and toxic compound, exerts its harmful effects mainly by affecting the production of mitochondrial ROS. The interaction between endoplasmic reticulum and mitochondria, as well as the potential regulation by the ER stress response, may play a crucial role in mediating these effects.

SEMINARS IN CANCER BIOLOGY (2021)

Article Biochemistry & Molecular Biology

Peroxiredoxins wear many hats: Factors that fashion their peroxide sensing personalities

Jesalyn Bolduc et al.

Summary: This review provides a tabulated overview of human and bacterial peroxiredoxins, focusing on structure, post-translational modifications, and protein-protein interactions. The study aims to understand the cellular operating power of Prdxs in both stress and non-stress conditions, utilizing various experimental techniques at cellular and atomic levels. Future research is needed to gain a clearer view on the specificities and functions of peroxiredoxins in different cellular contexts.

REDOX BIOLOGY (2021)

Article Biochemistry & Molecular Biology

Non-enzymatic lipid peroxidation initiated by photodynamic therapy drives a distinct ferroptosis-like cell death pathway

Sufang Shui et al.

Summary: The study shows that photodynamic therapy (PDT) can induce lipid peroxidation and cell death similar to ferroptosis, termed as liperoptosis, which is independent of lipoxygenase and ACSL4. Using a clinically approved photosensitizer, PDT effectively inhibits tumor growth through triggering lipid peroxidation and cell death. These findings suggest the potential value of using PDT to induce lipid peroxidation and ferroptosis-like cell death in vivo for cancer treatment and exploring the immunological effects of PDT.

REDOX BIOLOGY (2021)

Review Oncology

Mitochondrial DNA variation and cancer

Piotr K. Kopinski et al.

Summary: Variation in mitochondrial DNA is common in certain tumors. This review discusses the relevance of heritable, somatic, and ancient mtDNA variants to cancer, and how subtle changes in mtDNA lead to metabolic, epigenetic, and transcriptional changes that affect carcinogenesis.

NATURE REVIEWS CANCER (2021)

Review Biochemistry & Molecular Biology

The homeostatic role of hydrogen peroxide, superoxide anion and nitric oxide in the vasculature

Tiago J. Costa et al.

Summary: This review explores the essential roles of reactive oxygen and nitrogen species in physiological regulation of vascular function and the potential disruption of vascular homeostasis by excessive removal of these crucial responses by exogenous antioxidants.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

Article Medicine, Research & Experimental

Mitochondrial ROS promote mitochondrial dysfunction and inflammation in ischemic acute kidney injury by disrupting TFAM-mediated mtDNA maintenance

Meng Zhao et al.

Summary: Reducing mtROS levels attenuated renal dysfunction, mitochondrial damage, and inflammation in IRI-AKI mice. The loss of TFAM can impact mtDNA maintenance, mitochondrial energy metabolism, and cytokine release. Insights into the role of mtROS and TFAM in IRI-AKI provide potential therapeutic targets for renal repair.

THERANOSTICS (2021)

Review Cardiac & Cardiovascular Systems

NADPH oxidases and oxidase crosstalk in cardiovascular diseases: novel therapeutic targets

Yixuan Zhang et al.

NATURE REVIEWS CARDIOLOGY (2020)

Review Biochemistry & Molecular Biology

Staying in Healthy Contact: How Peroxisomes Interact with Other Cell Organelles

Yelena Sargsyan et al.

TRENDS IN MOLECULAR MEDICINE (2020)

Article Chemistry, Multidisciplinary

An Enzyme-Mimicking Single-Atom Catalyst as an Efficient Multiple Reactive Oxygen and Nitrogen Species Scavenger for Sepsis Management

Fangfang Cao et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

Article Biochemistry & Molecular Biology

Inhibiting the Activity of NADPH Oxidase in Cancer

Mariam M. Konate et al.

ANTIOXIDANTS & REDOX SIGNALING (2020)

Article Biochemistry & Molecular Biology

Nicotinamide Adenine Dinucleotide Phosphate Oxidase and Neurodegenerative Diseases: Mechanisms and Therapy

Liyan Hou et al.

ANTIOXIDANTS & REDOX SIGNALING (2020)

Article Pharmacology & Pharmacy

Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification

Jun Wan Shin et al.

BIOCHEMICAL PHARMACOLOGY (2020)

Review Oncology

Oncogenic pathways and the electron transport chain: a dangeROS liaison

Vittoria Raimondi et al.

BRITISH JOURNAL OF CANCER (2020)

Review Oncology

Metabolic rewiring and redox alterations in malignant pleural mesothelioma

Loredana Urso et al.

BRITISH JOURNAL OF CANCER (2020)

Article Biotechnology & Applied Microbiology

An engineered enzyme that targets circulating lactate to alleviate intracellular NADH:NAD+ imbalance

Anupam Patgiri et al.

NATURE BIOTECHNOLOGY (2020)

Article Biochemistry & Molecular Biology

Bladder Cancer Chemosensitivity Is Affected by Paraoxonase-2 Expression

Stefania Fumarola et al.

ANTIOXIDANTS (2020)

Review Cell Biology

Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

Helmut Sies et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

Article Biochemistry & Molecular Biology

The novel SOD mimetic GC4419 increases cancer cell killing with sensitization to ionizing radiation while protecting normal cells

Mohamed A. El-Mahdy et al.

FREE RADICAL BIOLOGY AND MEDICINE (2020)

Review Oncology

Oxidative Stress in Cancer

John D. Hayes et al.

CANCER CELL (2020)

Review Biochemistry & Molecular Biology

NADPH oxidases: Current aspects and tools

Katrin Schroeder

REDOX BIOLOGY (2020)

Article Biochemistry & Molecular Biology

Paracrine regulation and improvement of β-cell function by thioredoxin

Eva-Maria Hanschmann et al.

REDOX BIOLOGY (2020)

Review Biochemistry & Molecular Biology

Mitochondrial electron transport chain: Oxidative phosphorylation, oxidant production, and methods of measurement

Deirdre Nolfi-Donegan et al.

REDOX BIOLOGY (2020)

Review Cell Biology

The Complex Interplay between Antioxidants and ROS in Cancer

Isaac S. Harris et al.

TRENDS IN CELL BIOLOGY (2020)

Editorial Material Cell Biology

Endoplasmic Reticulum (ER) Stress Response Failure in Diseases

Kashi Raj Bhattarai et al.

TRENDS IN CELL BIOLOGY (2020)

Article Biochemistry & Molecular Biology

Isomeric O-methyl cannabidiolquinones with dual BACH1/NRF2 activity

Laura Casares et al.

REDOX BIOLOGY (2020)

Review Biochemistry & Molecular Biology

Oxidative stress and mitochondrial dysfunction in early-onset and late-onset preeclampsia

Reinaldo Marin et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2020)

Article Biochemistry & Molecular Biology

Paraoxonase-2 Silencing Enhances Sensitivity of A375 Melanoma Cells to Treatment with Cisplatin

Roberto Campagna et al.

ANTIOXIDANTS (2020)

Review Biochemistry & Molecular Biology

Redox Signaling from and to Peroxisomes: Progress, Challenges, and Prospects

Marc Fransen et al.

ANTIOXIDANTS & REDOX SIGNALING (2019)

Review Chemistry, Medicinal

Dimethyl fumarate, a two-edged drug: Current status and future directions

Nathaniel Edward Bennett Saidu et al.

MEDICINAL RESEARCH REVIEWS (2019)

Article Multidisciplinary Sciences

AhR controls redox homeostasis and shapes the tumor microenvironment in BRCA1-associated breast cancer

Shawn P. Kubli et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Biochemistry & Molecular Biology

Thiol regulation by Mn porphyrins, commonly known as SOD mimics

Ines Batinic-Haberle et al.

REDOX BIOLOGY (2019)

Review Cell Biology

Metabolic regulation of cell growth and proliferation

Jiajun Zhu et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

Article Biochemistry & Molecular Biology

Nrf2 Activation Promotes Lung Cancer Metastasis by Inhibiting the Degradation of Bach1

Luca Lignitto et al.

Review Biochemistry & Molecular Biology

Self-defense of macrophages against oxidative injury: Fighting for their own survival

Laszlo Virag et al.

REDOX BIOLOGY (2019)

Article Biochemistry & Molecular Biology

Pharmacological characterization of the seven human NOX isoforms and their inhibitors

Fiona Augsburger et al.

REDOX BIOLOGY (2019)

Article Multidisciplinary Sciences

Nestin regulates cellular redox homeostasis in lung cancer through the Keap1-Nrf2 feedback loop

Jiancheng Wang et al.

NATURE COMMUNICATIONS (2019)

Article Gastroenterology & Hepatology

NADPH Oxidase 1 in Liver Macrophages Promotes Inflammation and Tumor Development in Mice

Shuang Liang et al.

GASTROENTEROLOGY (2019)

Article Biochemistry & Molecular Biology

Structure and mechanisms of ROS generation by NADPH oxidases

Francesca Magnani et al.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2019)

Review Biotechnology & Applied Microbiology

Therapeutic targeting of the NRF2 and KEAP 1 partnership in chronic diseases

Antonio Cuadrado et al.

NATURE REVIEWS DRUG DISCOVERY (2019)

Review Biochemistry & Molecular Biology

Targeting Metabolic-Redox Circuits for Cancer Therapy

Kui Wang et al.

TRENDS IN BIOCHEMICAL SCIENCES (2019)

Review Biochemistry & Molecular Biology

ROS and the DNA damage response in cancer

Upadhyayula Sai Srinivas et al.

REDOX BIOLOGY (2019)

Review Biochemistry & Molecular Biology

NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis

Matthew Dodson et al.

REDOX BIOLOGY (2019)

Review Oncology

Targeting cancer vulnerabilities with high-dose vitamin C

Bryan Ngo et al.

NATURE REVIEWS CANCER (2019)

Review Biochemistry & Molecular Biology

The role of mitochondrial ROS in the aging brain

Rhoda Stefanatos et al.

FEBS LETTERS (2018)

Review Biochemistry & Molecular Biology

Mn Porphyrin-Based Redox-Active Drugs: Differential Effects as Cancer Therapeutics and Protectors of Normal Tissue Against Oxidative Injury

Ines Batinic-Haberle et al.

ANTIOXIDANTS & REDOX SIGNALING (2018)

Review Biochemistry & Molecular Biology

Redox Paradox: A Novel Approach to Therapeutics-Resistant Cancer

Luksana Chaiswing et al.

ANTIOXIDANTS & REDOX SIGNALING (2018)

Review Oncology

NRF2 and the Hallmarks of Cancer

Montserrat Rojo de la Vega et al.

CANCER CELL (2018)

Article Biochemistry & Molecular Biology

SIRT5 inhibits peroxisomal ACOX1 to prevent oxidative damage and is downregulated in liver cancer

Xiu-Fei Chen et al.

EMBO REPORTS (2018)

Article Biochemistry & Molecular Biology

ROS modifiers and NOX4 affect the expression of the survivin-associated radio-adaptive response

Jeffrey S. Murley et al.

FREE RADICAL BIOLOGY AND MEDICINE (2018)

Editorial Material Gastroenterology & Hepatology

Gut microbiota: a new way to take your vitamins

Joao Carlos Gomes-Neto et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2018)

Review Medicine, General & Internal

Favism and Glucose-6-Phosphate Dehydrogenase Deficiency

Lucio Luzzatto et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Review Cell Biology

ROS signalling in the biology of cancer

Jennifer N. Moloney et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2018)

Review Pharmacology & Pharmacy

The Pharmacokinetics of Fumaric Acid Esters Reveal Their In Vivo Effects

Ulrich Mrowietz et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2018)

Review Biochemistry & Molecular Biology

Nuclear Genomic Instability and Aging

Laura J. Niedernhofer et al.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 87 (2018)

Article Multidisciplinary Sciences

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

Evanna L. Mills et al.

NATURE (2018)

Review Pharmacology & Pharmacy

Oxidative Stress and Cancer

James E. Klaunig

CURRENT PHARMACEUTICAL DESIGN (2018)

Review Physiology

Intravenous Vitamin C for Cancer Therapy - Identifying the Current Gaps in Our Knowledge

Anitra C. Carr et al.

FRONTIERS IN PHYSIOLOGY (2018)

Review Chemistry, Multidisciplinary

Potential Therapeutic Applications of MnSODs and SOD-Mimetics

Rosalin Bonetta

CHEMISTRY-A EUROPEAN JOURNAL (2018)

Article Physiology

Gastrointestinal Handling of Water-Soluble Vitamins

Hamid M. Said et al.

COMPREHENSIVE PHYSIOLOGY (2018)

Article Pharmacology & Pharmacy

The novel Nrf2 inducer TFM-735 ameliorates experimental autoimmune encephalomyelitis in mice

Chika Higashi et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2017)

Article Biochemistry & Molecular Biology

Expression and characterization of recombinant bifunctional enzymes with glutathione peroxidase and superoxide dismutase activities

Tuchen Guan et al.

FREE RADICAL BIOLOGY AND MEDICINE (2017)

Review Pharmacology & Pharmacy

Targeting the Thioredoxin System for Cancer Therapy

Junmin Zhang et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2017)

Review Pharmacology & Pharmacy

Targeting Free Radicals in Oxidative Stress-Related Human Diseases

Patrik Poprac et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2017)

Article Clinical Neurology

Effects of fumarates on inflammatory human astrocyte responses and oligodendrocyte differentiation

Dylan A. Galloway et al.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2017)

Review Oncology

Axillary Nodal Management Following Neoadjuvant Chemotherapy A Review

Melissa Pilewskie et al.

JAMA ONCOLOGY (2017)

Review Oncology

Exercise-dependent regulation of the tumour microenvironment

Graeme J. Koelwyn et al.

NATURE REVIEWS CANCER (2017)

Article Biochemistry & Molecular Biology

Control of Oxidative Stress and Inflammation in Sickle Cell Disease with the Nrf2 Activator Dimethyl Fumarate

John D. Belcher et al.

ANTIOXIDANTS & REDOX SIGNALING (2017)

Review Cell Biology

TNF and ROS Crosstal in Inflammation

Heiko Blaser et al.

TRENDS IN CELL BIOLOGY (2016)

Article Cardiac & Cardiovascular Systems

Impaired compensation to femoral artery ligation in diet-induced obese mice is primarily mediated via suppression of collateral growth by Nox2 and p47phox

Matthew R. DiStasi et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2015)

Review Biochemistry & Molecular Biology

Evolution of NADPH Oxidase Inhibitors: Selectivity and Mechanisms for Target Engagement

Sebastian Altenhofer et al.

ANTIOXIDANTS & REDOX SIGNALING (2015)

Review Biochemistry & Molecular Biology

Oxidative stress, redox regulation and diseases of cellular differentiation

Zhi-Wei Ye et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2015)

Article Pharmacology & Pharmacy

Nox Inhibitors & Therapies: Rational Design of Peptidic and Small Molecule Inhibitors

M. Eugenia Cifuentes-Pagano et al.

CURRENT PHARMACEUTICAL DESIGN (2015)

Article Biochemistry & Molecular Biology

Nitrite and nitrate-dependent generation of anti-inflammatory fatty acid nitroalkenes

Meghan Delmastro-Greenwood et al.

FREE RADICAL BIOLOGY AND MEDICINE (2015)

Article Multidisciplinary Sciences

Oxidative stress inhibits distant metastasis by human melanoma cells

Elena Piskounova et al.

NATURE (2015)

Review Oncology

Cancer prevention and therapy through the modulation of the tumor microenvironment

Stephanie C. Casey et al.

SEMINARS IN CANCER BIOLOGY (2015)

Review Biochemistry & Molecular Biology

Role of lipid peroxidation derived 4-hydroxynonenal (4-HNE) in cancer: Focusing on mitochondria

Huiqin Zhong et al.

REDOX BIOLOGY (2015)

Review Biochemistry & Molecular Biology

Simple Biological Systems for Assessing the Activity of Superoxide Dismutase Mimics

Artak Tovmasyan et al.

ANTIOXIDANTS & REDOX SIGNALING (2014)

Review Biochemistry & Molecular Biology

SOD Therapeutics: Latest Insights into Their Structure-Activity Relationships and Impact on the Cellular Redox-Based Signaling Pathways

Ines Batinic-Haberle et al.

ANTIOXIDANTS & REDOX SIGNALING (2014)

Article Oncology

Vitamin C and survival among women with breast cancer: A Meta-analysis

Holly R. Harris et al.

EUROPEAN JOURNAL OF CANCER (2014)

Article Biochemistry & Molecular Biology

Molecular characterization of the thioredoxin system from Methanosarcina acetivorans

Addison C. McCarver et al.

FEBS JOURNAL (2014)

Meeting Abstract Biochemistry & Molecular Biology

TNF-α stimulation enhances ROS-dependent cell migration via NF-κB activation in liver cells

Kastl Lena et al.

FREE RADICAL BIOLOGY AND MEDICINE (2014)

Review Biochemistry & Molecular Biology

Role of vitamin E as a lipid-soluble peroxyl radical scavenger: in vitro and in vivo evidence

Etsuo Niki

FREE RADICAL BIOLOGY AND MEDICINE (2014)

Article Oncology

Radioprotective agents for radiation therapy: future trends

Roberta M. Johnke et al.

FUTURE ONCOLOGY (2014)

Review Oncology

Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles' heel?

Simran S. Sabharwal et al.

NATURE REVIEWS CANCER (2014)

Article Urology & Nephrology

Oxalate Nephropathy and Intravenous Vitamin C

L. Nicholas Cossey et al.

AMERICAN JOURNAL OF KIDNEY DISEASES (2013)

Review Biochemistry & Molecular Biology

Glutathione and glutathione analogues; Therapeutic potentials

Jian Hui Wu et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2013)

Article Biochemistry & Molecular Biology

Small molecules inhibit the interaction of Nrf2 and the Keap1 Kelch domain through a non-covalent mechanism

Douglas Marcotte et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2013)

Article Chemistry, Medicinal

Discovery of a small-molecule inhibitor and cellular probe of Keap1-Nrf2 protein-protein interaction

Longqin Hu et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2013)

Article Biochemistry & Molecular Biology

SOD1 Integrates Signals from Oxygen and Glucose to Repress Respiration

Amit R. Reddi et al.

Article Biochemistry & Molecular Biology

Comprehensive pharmacokinetic studies and oral bioavailability of two Mn porphyrin-based SOD mimics, MnTE-2-PyP5+ and MnTnHex-2-PyP5+

Tin Weitner et al.

FREE RADICAL BIOLOGY AND MEDICINE (2013)

Article Oncology

Does Vitamin E Prevent or Promote Cancer?

Chung S. Yang et al.

CANCER PREVENTION RESEARCH (2012)

Review Biochemistry & Molecular Biology

NADPH oxidase inhibitors: a decade of discovery from Nox2ds to HTS

Eugenia Cifuentes-Pagano et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2012)

Article Medicine, Research & Experimental

Effect of high-dose intravenous vitamin C on inflammation in cancer patients

Nina Mikirova et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2012)

Article Biochemistry & Molecular Biology

Paraoxonase 2 Deficiency Alters Mitochondrial Function and Exacerbates the Development of Atherosclerosis

Asokan Devarajan et al.

ANTIOXIDANTS & REDOX SIGNALING (2011)

Article Biochemistry & Molecular Biology

GSH monoethyl ester rescues mitochondrial defects in cystic fibrosis models

Mairead Kelly-Aubert et al.

HUMAN MOLECULAR GENETICS (2011)

Article Cell Biology

Intraperoxisomal redox balance in mammalian cells: oxidative stress and interorganellar cross-talk

Oksana Ivashchenko et al.

MOLECULAR BIOLOGY OF THE CELL (2011)

Review Biochemistry & Molecular Biology

Prodrug Approach for Increasing Cellular Glutathione Levels

Ivana Cacciatore et al.

MOLECULES (2010)

Article Medicine, Research & Experimental

Fulvene-5 potently inhibits NADPH oxidase 4 and blocks the growth of endothelial tumors in mice

Sulochana S. Bhandarkar et al.

JOURNAL OF CLINICAL INVESTIGATION (2009)

Article Biochemistry & Molecular Biology

Diversity of chemical mechanisms in thioredoxin catalysis revealed by single-molecule force spectroscopy

Raul Perez-Jimenez et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2009)

Article Multidisciplinary Sciences

ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis

Kaori Ishikawa et al.

SCIENCE (2008)

Review Physiology

The NOX family of ROS-generating NADPH oxidases: Physiology and pathophysiology

Karen Bedard et al.

PHYSIOLOGICAL REVIEWS (2007)

Article Biochemistry & Molecular Biology

The effects of mitochondrial iron homeostasis on cofactor specificity of superoxide dismutase 2

Mei Yang et al.

EMBO JOURNAL (2006)

Article Multidisciplinary Sciences

Modifying specific cysteines of the electrophile-sensing human Keap1 disrupt binding to the protein is insufficient to Nrf2 domain Neh2

AL Eggler et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Biochemistry & Molecular Biology

Structure and evolution of the serum paraoxonase family of detoxifying and anti-atherosclerotic enzymes

M Harel et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2004)

Review Biochemistry & Molecular Biology

Role of reactive oxygen species in skin carcinogenesis

C Nishigori et al.

ANTIOXIDANTS & REDOX SIGNALING (2004)

Article Multidisciplinary Sciences

Quality control in the endoplasmic reticulum protein factory

R Sitia et al.

NATURE (2003)