期刊
ANTIOXIDANTS
卷 11, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/antiox11061128
关键词
reactive oxygen species; oxidative stress; antioxidants; cancer therapy
资金
- National Natural Science Foundation of China [81790251, 52007087, 82103168, 82073246]
- Natural Science Foundation of Zhejiang Province, China [LY22C110001]
- Natural Science Foundation of Ningbo City, China [202003N4116]
- Educational Commission of Zhejiang Province, China [Y202044047]
- Fundamental Research Funds for the Provincial Universities of Zhejiang [SJLZ2022001]
Cancer is associated with oxidative stress, and targeting this imbalance between reactive oxygen species (ROS) and antioxidants may have therapeutic potential. However, the clinical efficacy of antioxidants in cancer treatment remains uncertain. This review discusses the rationale and recent advances in antioxidant therapy for cancer, as well as potential strategies for improving its effectiveness.
Cancer is characterized by increased oxidative stress, an imbalance between reactive oxygen species (ROS) and antioxidants. Enhanced ROS accumulation, as a result of metabolic disturbances and signaling aberrations, can promote carcinogenesis and malignant progression by inducing gene mutations and activating pro-oncogenic signaling, providing a possible rationale for targeting oxidative stress in cancer treatment. While numerous antioxidants have demonstrated therapeutic potential, their clinical efficacy in cancer remains unproven. Here, we review the rationale for, and recent advances in, pre-clinical and clinical research on antioxidant therapy in cancer, including targeting ROS with nonenzymatic antioxidants, such as NRF2 activators, vitamins, N-acetylcysteine and GSH esters, or targeting ROS with enzymatic antioxidants, such as NOX inhibitors and SOD mimics. In addition, we will offer insights into prospective therapeutic options for improving the effectiveness of antioxidant therapy, which may expand its applications in clinical cancer treatment.
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