Leukocyte Telomere Length Variability as a Potential Biomarker in Patients with PolyQ Diseases

SCA1, SCA2, and SCA3 are the most common forms of SCAs among the polyglutamine disorders, which include Huntington's Disease (HD). We investigated the relationship between leukocyte telomere length (LTL) and the phenotype of SCA1, SCA2, and SCA3, comparing them with HD. The results showed that LTL was significantly reduced in SCA1 and SCA3 patients, while LTL was significantly longer in SCA2 patients. A significant negative relationship between LTL and age was observed in SCA1 but not in SCA2 subjects. LTL of SCA3 patients depend on both patient's age and disease duration. The number of CAG repeats did not affect LTL in the three SCAs. Since LTL is considered an indirect marker of an inflammatory response and oxidative damage, our data suggest that in SCA1 inflammation is present already at an early stage of disease similar to in HD, while in SCA3 inflammation and impaired antioxidative processes are associated with disease progression. Interestingly, in SCA2, contrary to SCA1 and SCA3, the length of leukocyte telomeres does not reduce with age. We have observed that SCAs and HD show a differing behavior in LTL for each subtype, which could constitute relevant biomarkers if confirmed in larger cohorts and longitudinal studies.

Automated summary

SCA1, SCA2, and SCA3 have different effects on leukocyte telomere length (LTL), with SCA1 and SCA3 patients showing significant reduction in LTL and SCA2 patients showing significant increase in LTL. The relationship between LTL and age varies among the subtypes, with SCA1 patients having a significant negative relationship between LTL and age. The number of CAG repeats does not affect LTL in these SCAs. These findings suggest that LTL could serve as a potential biomarker for differentiating between SCAs and HD, but further research is needed for validation in larger cohorts and longitudinal studies.