期刊
BIOMOLECULES
卷 12, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/biom12070869
关键词
ATRA; atherosclerosis; adipocytes; RARs; immunity
Atherosclerosis is a major risk factor for heart attacks and stroke, and all-trans retinoic acid (ATRA) plays an important role in inflammatory cells involved in this process.
Atherosclerosis is a major risk factor for myocardial infarction and ischemic stroke, which are the leading cause of death worldwide. All-trans retinoic acid (ATRA) is a natural derivative of essential vitamin A. Numerous studies have shown that ATRA plays an important role in cell proliferation, cell apoptosis, cell differentiation, and embryonic development. All-trans retinoic acid (ATRA) is a ligand of retinoic acid receptors that regulates various biological processes by activating retinoic acid signals. In this paper, the metabolic processes of ATRA were reviewed, with emphasis on the effects of ATRA on inflammatory cells involved in the process of atherosclerosis.
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