Biotechnological Approaches to Optimize the Production of Amaryllidaceae Alkaloids

Amaryllidaceae alkaloids (AAs) are plant specialized metabolites with therapeutic properties exclusively produced by the Amaryllidaceae plant family. The two most studied representatives of the family are galanthamine, an acetylcholinesterase inhibitor used as a treatment of Alzheimer's disease, and lycorine, displaying potent in vitro and in vivo cytotoxic and antiviral properties. Unfortunately, the variable level of AAs' production in planta restricts most of the pharmaceutical applications. Several biotechnological alternatives, such as in vitro culture or synthetic biology, are being developed to enhance the production and fulfil the increasing demand for these AAs plant-derived drugs. In this review, current biotechnological approaches to produce different types of bioactive AAs are discussed.

Automated summary

Amaryllidaceae alkaloids (AAs) are therapeutic plant metabolites exclusively produced by the Amaryllidaceae plant family. The production variability of AAs in plants hinders their pharmaceutical applications. Biotechnological approaches such as in vitro culture and synthetic biology are being developed to enhance the production of these plant-derived drugs.