4.7 Review

Understanding Necroptosis in Pancreatic Diseases

期刊

BIOMOLECULES
卷 12, 期 6, 页码 -

出版社

MDPI
DOI: 10.3390/biom12060828

关键词

necroptosis; pancreatitis; pancreatic cancer; RIPK; MLKL; TNF

资金

  1. Science and Technology Projects of Chengguan District in Lanzhou [2020-2-11-4]
  2. Traditional Chinese Medicine Scientific Research Project of Gansu Province [GZKP-2020-28]

向作者/读者索取更多资源

This article introduces the role and molecular mechanisms of necroptosis in pancreatic diseases and explores its potential as a new therapeutic target.
Intermediate between apoptosis and necrosis, necroptosis is a regulated caspase-independent programmed cell death that induces an inflammatory response and mediates cancer development. As our understanding improves, its role in the physiopathology of numerous diseases, including pancreatic diseases, has been reconsidered, and especially in pancreatitis and pancreatic cancer. However, the exact pathogenesis remains elusive, even though some studies have been conducted on these diseases. Its unique mechanisms of action in diseases are expected to bring prospects for the treatment of pancreatic diseases. Therefore, it is imperative to further explore its molecular mechanism in pancreatic diseases in order to identify novel therapeutic options. This article introduces recent related research on necroptosis and pancreatic diseases, explores necroptosis-related molecular pathways, and provides a theoretical foundation for new therapeutic targets for pancreatic diseases.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据