4.7 Review

Role of Regulatory T Cells in Skeletal Muscle Regeneration: A Systematic Review

期刊

BIOMOLECULES
卷 12, 期 6, 页码 -

出版社

MDPI
DOI: 10.3390/biom12060817

关键词

T regulatory cell; skeletal muscle; muscle repair; regeneration; regulatory microenvironment

资金

  1. FAPERJ (Fundacao de Amparo a Pesquisa do Rio de Janeiro)
  2. CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico)
  3. Fluminense Federal University (UFF)
  4. FIOCRUZ
  5. FAPERJ
  6. UFF

向作者/读者索取更多资源

This systematic review summarizes the role of Treg in muscle repair and their therapeutic potential in skeletal muscle injuries. The review provides comprehensive analysis of the literature and guidance on methodology.
Muscle injuries are frequent in individuals with genetic myopathies and in athletes. Skeletal muscle regeneration depends on the activation and differentiation of satellite cells present in the basal lamina of muscle fibers. The skeletal muscle environment is critical for repair, metabolic and homeostatic function. Regulatory T cells (Treg) residing within skeletal muscle comprise a distinct and special cell population that modifies the inflammatory environment by secreting cytokines and amphiregulin, an epidermal growth factor receptor (EGFR) ligand that acts directly upon satellite cells, promoting tissue regeneration. This systematic review summarizes the current knowledge regarding the role of Treg in muscle repair and discusses their therapeutic potential in skeletal muscle injuries. A bibliographic search was carried out using the terms Treg and muscle regeneration and repair, covering all articles up to April 2021 indexed in the PubMed and EMBASE databases. The search included only published original research in human and experimental animal models, with further data analysis based on the PICO methodology, following PRISMA definitions and Cochrane guidelines.

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