Structures and Biological Activities of Alkaloids Produced by Mushrooms, a Fungal Subgroup

Alkaloids are a wide family of basic N-containing natural products, whose research has revealed bioactive compounds of pharmacological interest. Studies on these compounds have focused more attention on those produced by plants, although other types of organisms have also been proven to synthesize bioactive alkaloids, such as animals, marine organisms, bacteria, and fungi. This review covers the findings of the last 20 years (2002-2022) related to the isolation, structures, and biological activities of the alkaloids produced by mushrooms, a fungal subgroup, and their potential to develop drugs and agrochemicals. In some cases, the synthesis of the reviewed compounds and structure-activity relationship studies have been described.

Automated summary

This review summarizes the research findings on alkaloids produced by mushrooms in the last 20 years (2002-2022), including their isolation, structures, and biological activities, as well as their potential in drug and agrochemical development. The synthesis of some compounds and structure-activity relationship studies are also described.