4.7 Article

Djhsp60 Is Required for Planarian Regeneration and Homeostasis

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Biochemistry & Molecular Biology

Decoding Stem Cells: An Overview on Planarian Stem Cell Heterogeneity and Lineage Progression

M. Dolores Molina et al.

Summary: Planarians are flatworms capable of regenerating any part of their bodies, thanks to the presence of somatic pluripotent stem cells known as neoblasts. The study of neoblasts has been advanced through technologies like FACS isolation, RNAi analysis, and single-cell sequencing, leading to a deeper understanding of their biology and differentiation into specific cell types within planarians.

BIOMOLECULES (2021)

Article Biology

Ongoing repair of migration-coupled DNA damage allows planarian adult stem cells to reach wound sites

Sounak Sahu et al.

Summary: The study found that adult stem cells of planarian flatworms undergo changes in nuclear shape and increased DNA damage during migration, but this damage reduces once they reach the wound site. Stem cells with induced DNA damage prior to migration have delayed initiation and migrating cells are more sensitive to further DNA damage. RNAi-mediated knockdown of DNA repair pathway components impairs normal stem cell migration, showing that active DNA repair mechanisms are essential for successful migration.
Article Cell & Tissue Engineering

Mitochondrial state determines functionally divergent stem cell population in planaria

Mohamed Mohamed Haroon et al.

Summary: The study demonstrates that planarian pluripotent stem cells have low mitochondrial mass, which is a hallmark feature, and provides a mechanism to isolate live, functionally active PSCs from different cell cycle stages (G0/G1 and S, G2/M). Mitochondrial metabolism changes, characteristic of PSCs, are conserved in planaria and play a key role in organismal regeneration.

STEM CELL REPORTS (2021)

Article Biochemistry & Molecular Biology

A Spatiotemporal Characterisation of Redox Molecules in Planarians, with a Focus on the Role of Glutathione during Regeneration

Karolien Bijnens et al.

Summary: In this study, in vivo imaging was used to locate and analyze reactive oxygen species (ROS) during different physiological stages in the regenerative planarian Schmidtea mediterranea, revealing a well-equipped redox system in the gut and epidermis. The pharmacological inhibition or RNA interference of the redox balance showed alterations in the regeneration process, affecting tails more significantly. Focusing on glutathione, a reduction in its content led to regenerative failure with tissue lesions and underlying stem cell alterations. This highlights the intertwined relationship between ROS and antioxidants in animal physiology.

BIOMOLECULES (2021)

Review Neurosciences

Interplay Between Mitochondrial Oxidative Disorders and Proteostasis in Alzheimer's Disease

Emilio Llanos-Gonzalez et al.

FRONTIERS IN NEUROSCIENCE (2020)

Review Biochemistry & Molecular Biology

Complex Destabilization in the Mitochondrial Chaperonin Hsp60 Leads to Disease

Alejandro Rodriguez et al.

FRONTIERS IN MOLECULAR BIOSCIENCES (2020)

Article Ophthalmology

Sodium Iodate Disrupted the Mitochondrial-Lysosomal Axis in Cultured Retinal Pigment Epithelial Cells

Ying-Cheng Lin et al.

JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS (2018)

Article Multidisciplinary Sciences

Cell type transcriptome atlas for the planarian Schmidtea mediterranea

Christopher T. Fincher et al.

SCIENCE (2018)

Article Microbiology

Involvement of a host Cathepsin L in symbiont-induced cell death

Suzanne M. Peyer et al.

MICROBIOLOGYOPEN (2018)

Article Biochemistry & Molecular Biology

HSP60 is required for stemness and proper differentiation of mouse embryonic stem cells

Nan-Hee Seo et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2018)

Review Developmental Biology

The role of mitochondria in axon development and regeneration

George M. Smith et al.

DEVELOPMENTAL NEUROBIOLOGY (2018)

Review Biochemistry & Molecular Biology

BCL-2 family proteins: changing partners in the dance towards death

Justin Kale et al.

CELL DEATH AND DIFFERENTIATION (2018)

Review Medicine, Research & Experimental

The Mitochondrial Unfolded Protein Response: Role in Cellular Homeostasis and Disease

I. De et al.

CURRENT MOLECULAR MEDICINE (2017)

Article Biochemistry & Molecular Biology

Mitochondrial CCAR2/DBC1 is required for cell survival against rotenone-induced mitochondrial stress

Wootae Kim et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

Article Developmental Biology

Essential role for the planarian intestinal GATA transcription factor in stem cells and regeneration

Natasha M. Flores et al.

DEVELOPMENTAL BIOLOGY (2016)

Article Multidisciplinary Sciences

Mitochondrial function controls intestinal epithelial stemness and proliferation

Emanuel Berger et al.

NATURE COMMUNICATIONS (2016)

Article Biochemistry & Molecular Biology

Mitochondrial Heat Shock Protein (Hsp) 70 and Hsp10 Cooperate in the Formation of Hsp60 Complexes

Lena Boettinger et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

Article Cell Biology

Reactive Oxygen Species in Planarian Regeneration: An Upstream Necessity for Correct Patterning and Brain Formation

Nicky Pirotte et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2015)

Article Biochemistry & Molecular Biology

Mitochondrial NADP+-dependent isocitrate dehydrogenase knockdown inhibits tumorigenicity of melanoma cells

Sung Hwan Kim et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2014)

Article Gastroenterology & Hepatology

Heat shock protein 70 is required for optimal liver regeneration after partial hepatectomy in mice

Joshua H. Wolf et al.

LIVER TRANSPLANTATION (2014)

Article Chemistry, Medicinal

Effects of (-)-epicatechin and derivatives on nitric oxide mediated induction of mitochondrial proteins

Aldo Moreno-Ulloa et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2013)

Article Chemistry, Medicinal

Molecular Chaperone Disorders: Defective Hsp60 in Neurodegeneration

Peter Bross et al.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2013)

Article Biochemical Research Methods

Streaming fragment assignment for real-time analysis of sequencing experiments

Adam Roberts et al.

NATURE METHODS (2013)

Article Developmental Biology

Amputation induces stem cell mobilization to sites of injury during planarian regeneration

Otto C. Guedelhoefer et al.

DEVELOPMENT (2012)

Article Biochemical Research Methods

Fast gapped-read alignment with Bowtie 2

Ben Langmead et al.

NATURE METHODS (2012)

Article Biochemistry & Molecular Biology

Mitochondrial dysfunction induced by knockdown of mortalin is rescued by Parkin

Hui Yang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2011)

Article Biotechnology & Applied Microbiology

A proteomics approach to decipher the molecular nature of planarian stem cells

Enrique Fernandez-Taboada et al.

BMC GENOMICS (2011)

Article Biochemistry & Molecular Biology

The Human Mitochondrial Transcriptome

Tim R. Mercer et al.

Article Developmental Biology

Stem cell-based growth, regeneration, and remodeling of the planarian intestine

David J. Forsthoefel et al.

DEVELOPMENTAL BIOLOGY (2011)

Article Biochemistry & Molecular Biology

Autophagy and apoptosis in planarians

Cristina Gonzalez-Estevez et al.

APOPTOSIS (2010)

Article Biotechnology & Applied Microbiology

Differential expression analysis for sequence count data

Simon Anders et al.

GENOME BIOLOGY (2010)

Review Biochemistry & Molecular Biology

Importing Mitochondrial Proteins: Machineries and Mechanisms

Agnieszka Chacinska et al.

Article Developmental Biology

A mortalin-like gene is crucial for planarian stem cell viability

Maria Conte et al.

DEVELOPMENTAL BIOLOGY (2009)

Article Multidisciplinary Sciences

The p53-cathepsin axis cooperates with ROS to activate programmed necrotic death upon DNA damage

Ho-Chou Tu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Review Oncology

Hsp60 expression, new locations, functions and perspectives for cancer diagnosis and therapy

Francesco Cappello et al.

CANCER BIOLOGY & THERAPY (2008)

Article Biochemistry & Molecular Biology

The lysosomal-mitochondrial axis theory of postmitotic aging and cell death

Alexei Terman et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2006)

Article Cell Biology

Isolation of planarian X-ray-sensitive stem cells by fluorescence-activated cell sorting

Tetsutaro Hayashi et al.

DEVELOPMENT GROWTH & DIFFERENTIATION (2006)

Article Cell Biology

DjPiwi-1, a member of the PAZ-Piwi gene family, defines a subpopulation of planarian stem cells

Leonardo Rossi et al.

DEVELOPMENT GENES AND EVOLUTION (2006)

Review Oncology

Role of mitochondria as the gardens of cell death

R Kim et al.

CANCER CHEMOTHERAPY AND PHARMACOLOGY (2006)

Article Multidisciplinary Sciences

SMEDWI-2 is a PIWI-like protein that regulates planarian stem cells

PW Reddien et al.

SCIENCE (2005)

Article Multidisciplinary Sciences

Heat-shock protein 60 is required for blastema formation and maintenance during regeneration

S Makino et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Biochemistry & Molecular Biology

Human acyl-CoA dehydrogenase-9 plays a novel role in the mitochondrial β-oxidation of unsaturated fatty acids

R Ensenauer et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Anatomy & Morphology

Expression of heat-shock protein 70 during limb development and regeneration in the axolotl

M Lévesque et al.

DEVELOPMENTAL DYNAMICS (2005)

Article Cell Biology

Distribution of the stem cells (neoblasts) in the planarian Dugesia japonica

H Orii et al.

DEVELOPMENT GENES AND EVOLUTION (2005)