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Four-colour FRET reveals directionality in the Hsp90 multicomponent machinery
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Mutational analysis of TSC1 and TSC2 in Japanese patients with tuberous sclerosis complex revealed higher incidence of TSC1 patients than previously reported
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NATURE STRUCTURAL & MOLECULAR BIOLOGY (2013)
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Chrisostomos Prodromou
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The folliculin-FNIP1 pathway deleted in human Birt-Hogg-Dube syndrome is required for murine B-cell development
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BLOOD (2012)
Quantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition
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CELLULAR SIGNALLING (2012)
Disruption of Fnip1 Reveals a Metabolic Checkpoint Controlling B Lymphocyte Development
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IMMUNITY (2012)
Molecular chaperone complexes with antagonizing activities regulate stability and activity of the tumor suppressor LKB1
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ONCOGENE (2012)
BRCA1 and HSP90 cooperate in homologous and non-homologous DNA double-strand-break repair and G2/M checkpoint activation
Shane R. Stecklein et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
SAHA shows preferential cytotoxicity in mutant p53 cancer cells by destabilizing mutant p53 through inhibition of the HDAC6-Hsp90 chaperone axis
D. Li et al.
CELL DEATH AND DIFFERENTIATION (2011)
Tsc2 gene inactivation causes a more severe epilepsy phenotype than Tsc1 inactivation in a mouse model of Tuberous Sclerosis Complex
Ling-Hui Zeng et al.
HUMAN MOLECULAR GENETICS (2011)
Dynamic Interaction of Hsp90 with Its Client Protein p53
Sung Jean Park et al.
JOURNAL OF MOLECULAR BIOLOGY (2011)
Functional Inactivation of Endogenous MDM2 and CHIP by HSP90 Causes Aberrant Stabilization of Mutant p53 in Human Cancer Cells
Dun Li et al.
MOLECULAR CANCER RESEARCH (2011)
Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90
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NATURE CHEMICAL BIOLOGY (2011)
Structural analysis of the interaction between Hsp90 and the tumor suppressor protein p53
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NATURE STRUCTURAL & MOLECULAR BIOLOGY (2011)
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Sung Jean Park et al.
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PHYSIOLOGICAL REVIEWS (2011)
Geldanamycin Analog 17-DMAG Limits Apoptosis in Human Peripheral Blood Cells by Inhibition of p53 Activation and its Interaction with Heat-Shock Protein 90 kDa after Exposure to Ionizing Radiation
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RADIATION RESEARCH (2011)
Plenary Lecture Energy sensing by the AMP-activated protein kinase and its effects on muscle metabolism
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PROCEEDINGS OF THE NUTRITION SOCIETY (2011)
Heat shock protein 90 regulates the expression of Wilms tumor 1 protein in myeloid leukemias
Hima Bansal et al.
BLOOD (2010)
Heat Shock Protein 90 Inhibition Depletes LATS1 and LATS2, Two Regulators of the Mammalian Hippo Tumor Suppressor Pathway
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CANCER RESEARCH (2010)
Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes
Hiroyuki Takai et al.
GENES & DEVELOPMENT (2010)
ATP Binding to Hsp90 Is Sufficient for Effective Chaperoning of p53 Protein
Dawid Walerych et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Biological and Structural Basis for Aha1 Regulation of Hsp90 ATPase Activity in Maintaining Proteostasis in the Human Disease Cystic Fibrosis
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MOLECULAR BIOLOGY OF THE CELL (2010)
CK2 Phospho-Dependent Binding of R2TP Complex to TEL2 Is Essential for mTOR and SMG1 Stability
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MOLECULAR CELL (2010)
Inactivation of the FLCN Tumor Suppressor Gene Induces TFE3 Transcriptional Activity by Increasing Its Nuclear Localization
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PLOS ONE (2010)
Targeting the dynamic HSP90 complex in cancer
Jane Trepel et al.
NATURE REVIEWS CANCER (2010)
Tubulin acetylation favors Hsp90 recruitment to microtubules and stimulates the signaling function of the Hsp90 clients Akt/PKB and p53
Julien Giustiniani et al.
CELLULAR SIGNALLING (2009)
Impact of heat-shock protein 90 on cancer metastasis
Shinji Tsutsumi et al.
FUTURE ONCOLOGY (2009)
The tuberous sclerosis proteins regulate formation of the primary cilium via a rapamycin-insensitive and polycystin 1-independent pathway
Tiffiney R. Hartman et al.
HUMAN MOLECULAR GENETICS (2009)
Cooperative Regulation of the Interferon Regulatory Factor-1 Tumor Suppressor Protein by Core Components of the Molecular Chaperone Machinery
Vikram Narayan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
A Truncated Form of p23 Down-regulates Telomerase Activity via Disruption of Hsp90 Function
Sang Hyeok Woo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
The large conformational changes of Hsp90 are only weakly coupled to ATP hydrolysis
Moritz Mickler et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2009)
Dissection of the ATP-induced conformational cycle of the molecular chaperone Hsp90
Martin Hessling et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2009)
The TSC1-TSC2 complex: a molecular switchboard controlling cell growth
Jingxiang Huang et al.
BIOCHEMICAL JOURNAL (2008)
Identification and characterization of a novel folliculin-interacting protein FNIP2
Hisashi Hasumi et al.
GENE (2008)
The Hsp90 chaperone machinery
Sebastian Karl Wandinger et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Kidney-targeted Birt-Hogg-Dube gene inactivation in a mouse model: Erk1/2 and Akt-mTOR activation, cell hyperproliferation, and polycystic kidneys
Masaya Baba et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2008)
Hsp90-dependent activation of protein kinases is regulated by chaperone-targeted dephosphorylation of Cdc37
Cara K. Vaughan et al.
MOLECULAR CELL (2008)
Overlapping neurologic and cognitive phenotypes in patients with TSC1 or TSC2 mutations
F. E. Jansen et al.
NEUROLOGY (2008)
Inhibition of homologous recombination repair in irradiated tumor cells pretreated with Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)
Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis
Xiaodong Wang et al.
CELL (2006)
Structural analysis of E-coli hsp90 reveals dramatic nucleotide-dependent conformational rearrangements
Andrew K. Shiau et al.
CELL (2006)
Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling
Masaya Baba et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Tsc1 haploinsufficiency without mammalian target of rapamycin activation is sufficient for renal cyst formation in Tsc1+/- mice
Catherine Wilson et al.
CANCER RESEARCH (2006)
Localization of Sites of Interaction between p23 and Hsp90 in Solution
Maria A. Martinez-Yamout et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Crystal structure of an Hsp90-nucleotide-p23/Sba1 closed chaperone complex
MMU Ali et al.
NATURE (2006)
TSC1 stabilizes TSC2 by inhibiting the interaction between TSC2 and the HERC1 ubiquitin ligase
H Chong-Kopera et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
The co-chaperone p23 arrests the Hsp90 ATPase cycle to trap client proteins
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JOURNAL OF MOLECULAR BIOLOGY (2006)
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JOURNAL OF BIOCHEMISTRY (2006)
Folding and quality control of the VHL tumor suppressor proceed through distinct chaperone pathways
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CELL (2005)
Mutational analysis of the TSC1 and TSC2 genes in a diagnostic setting:: genotype-phenotype correlations and comparison of diagnostic DNA techniques in Tuberous Sclerosis Complex
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EUROPEAN JOURNAL OF HUMAN GENETICS (2005)
Co-chaperone regulation of conformational switching in the Hsp90 ATPase cycle
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JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Hsp90 regulates the activity of wild type p53 under physiological and elevated temperatures
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JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Hsp90 chaperones wild-type p53 tumor suppressor protein
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JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
The Co-chaperone Sba1 connects the ATPase reaction of Hsp90 to the progression of the chaperone cycle
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JOURNAL OF MOLECULAR BIOLOGY (2004)
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A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors
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NATURE (2003)
Tuberous sclerosis complex gene products, tuberin and hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb
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Heat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stability
J Boudeau et al.
BIOCHEMICAL JOURNAL (2003)
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CURRENT CANCER DRUG TARGETS (2003)
Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling
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CRINEPT-TROSY NMR reveals p53 core domain bound in an unfolded form to the chaperone Hsp90
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TSC1 and TSC2 mutations in tuberous sclerosis, the associated phenotypes and a model to explain observed TSC1/TSC2 frequency ratios
N Langkau et al.
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Evidence for separable functions of tuberous sclerosis gene products in mammalian cell cycle regulation
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HUMAN MOLECULAR GENETICS (2002)
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Pathological mutations in TSC1 and TSC2 disrupt the interaction between hamartin and tuberin
AK Hodges et al.
HUMAN MOLECULAR GENETICS (2001)
Co-chaperones Bag-1, Hop and Hsp40 regulate Hsc70 and Hsp9O interactions with wild-type or mutant p53
FW King et al.
EMBO JOURNAL (2001)
A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice
T Kobayashi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Mutational analysis in a cohort of 224 tuberous sclerosis patients indicates increased severity of TSC2, compared with TSC1, disease in multiple organs
SL Dabora et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2001)
The tuberous sclerosis-1 (TSC1) gene product hamartin suppresses cell growth and augments the expression of the TSC2 product tuberin by inhibiting its ubiquitination
G Benvenuto et al.
ONCOGENE (2000)
Distribution of Tsc1 protein detected by immunohistochemistry in various normal rat tissues and the renal carcinomas of Eker rat: Detection of limited colocalization with Tsc1 and Tsc2 gene products in vivo
T Fukuda et al.
LABORATORY INVESTIGATION (2000)
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