期刊
BIOMOLECULES
卷 12, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/biom12070928
关键词
tuberous sclerosis complex (TSC); Tsc1 (hamartin); Tsc2 (tuberin); heat shock protein 90 (Hsp90); FNIP1; FNIP2; co-chaperones; cancer; renal cell carcinoma; kidney cancer
资金
- National Institute of General Medical Sciences of the National Institutes of Health [R35GM139584]
- Carol M. Baldwin Breast Cancer Fund
- SUNY Upstate Medical University
- Upstate Foundation
This article reviews the literature on FNIP1, FNIP2, and Tsc1 as co-chaperones and discusses their potential impact on normal cellular function and human diseases.
Heat shock protein-90 (Hsp90) is an ATP-dependent molecular chaperone that is tightly regulated by a group of proteins termed co-chaperones. This chaperone system is essential for the stabilization and activation of many key signaling proteins. Recent identification of the co-chaperones FNIP1, FNIP2, and Tsc1 has broadened the spectrum of Hsp90 regulators. These new co-chaperones mediate the stability of critical tumor suppressors FLCN and Tsc2 as well as the various classes of Hsp90 kinase and non-kinase clients. Many early observations of the roles of FNIP1, FNIP2, and Tsc1 suggested functions independent of FLCN and Tsc2 but have not been fully delineated. Given the broad cellular impact of Hsp90-dependent signaling, it is possible to explain the cellular activities of these new co-chaperones by their influence on Hsp90 function. Here, we review the literature on FNIP1, FNIP2, and Tsc1 as co-chaperones and discuss the potential downstream impact of this regulation on normal cellular function and in human diseases.
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