期刊
VACCINES
卷 10, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/vaccines10060921
关键词
transplanted patients; SARS-CoV-2; BNT162b2 vaccine; third dose; kidney; DSA; anti-HLA antibodies
资金
- Fondazione Cariplo [2020-1374]
- Ministero della Salute, Ricerca Finalizzata grant BIAS [2020-12371760]
- Ricerca Corrente IRCCS Fondazione Policlinico San Matteo [RF-5X1000-2018-cod, 090000X120, 8073621]
This study investigated the role of a third dose of the BNT162b2 vaccine in kidney transplant recipients. The researchers found an increased immune response, especially in terms of T cell response to the Spike protein, after the third dose. However, the seroconversion rate remained below 50%. Mycophenolate treatment, steroid administration, and age appeared to be associated with a poor immune response.
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has severely impacted on public health, mainly on immunosuppressed patients, including solid organ transplant recipients. Vaccination represents a valuable tool for the prevention of severe SARS-CoV-2 infection, and the immunogenicity of mRNA vaccines has been evaluated in transplanted patients. In this study, we investigated the role of a third dose of the BNT162b2 vaccine in a cohort of kidney transplant recipients, analyzing both humoral and cell-mediated responses. We observed an increased immune response after the third dose of the vaccine, especially in terms of Spike-specific T cell response. The level of seroconversion remained lower than 50% even after the administration of the third dose. Mycophenolate treatment, steroid administration and age seemed to be associated with a poor immune response. In our cohort, 11/45 patients experienced a SARS-CoV-2 infection after the third vaccine dose. HLA antibodies appearance was recorded in 7 out 45 (15.5%) patients, but none of the patients developed acute renal rejection. Further studies for the evaluation of long-term immune responses are still ongoing, and the impact of a fourth dose of the vaccine will be evaluated.
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