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Article
Medicine, General & Internal
Jonathan Yap et al.
Summary: Data from the national registry in Singapore indicate an increased incidence of pericarditis and myocarditis in younger men after COVID-19 mRNA vaccination.
ANNALS ACADEMY OF MEDICINE SINGAPORE
(2022)
Article
Medicine, General & Internal
Francisco Tsz Tsun Lai et al.
Summary: This study found a higher association between BNT162b2 vaccination and carditis, while no similar association was found for CoronaVac. The risk of carditis after BNT162b2 vaccination was mainly observed after the second dose. This increased risk should be weighed against the benefits of vaccination.
ANNALS OF INTERNAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Dongngan T. Truong et al.
Summary: This study retrospectively analyzed the clinical characteristics and short-term outcomes of young individuals with suspected myocarditis after COVID-19 vaccination. The results showed that most cases of suspected myocarditis had a mild clinical course with rapid resolution of symptoms, and abnormal findings on cardiac MRI were frequent.
Article
Immunology
Gilbert T. Chua et al.
Summary: There is a significant increase in the risk of acute myocarditis/pericarditis following Comirnaty vaccination among Chinese male adolescents, especially after the second dose. It is recommended for Hong Kong adolescents to receive only one dose of the Comirnaty vaccine.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Virology
Wongi Woo et al.
Summary: Myocarditis after COVID-19 mRNA vaccination mainly affects young males, with milder clinical symptoms and favorable overall prognosis. Patients who received the BNT162b2 vaccine had fewer systemic symptoms and left ventricular dysfunction compared to those who received the mRNA-1273 vaccine.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Stephane Heymans et al.
Summary: The risk of acute myocarditis associated with COVID-19 mRNA vaccination is rare and usually resolves quickly, while the risks of hospitalization and death from COVID-19 are greater. Therefore, COVID-19 vaccination is recommended for adolescents and adults.
NATURE REVIEWS CARDIOLOGY
(2022)
Letter
Medicine, General & Internal
Dror Mevorach et al.
Summary: According to an active surveillance program by the Israeli Ministry of Health, the risk of myocarditis in adolescents within 21 days after receiving the first and second dose of BNT162b2 vaccine is higher among male recipients and lower among female recipients.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Immunology
Ulrikka Nygaard et al.
Summary: A nationwide study in Denmark found that the incidence of myopericarditis after Pfizer-BioNTech mRNA COVID-19 vaccination was higher among males aged 12-17 years compared to reports from the United States.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2022)
Article
Immunology
Young June Choe et al.
Summary: In a nationwide retrospective cohort study in South Korea, the BNT162b2 mRNA Covid-19 vaccine was found to be safe and effective in adolescents, significantly reducing the risk of SARS-CoV-2 infection and showing a high level of vaccine effectiveness.
Article
Immunology
Saskia Euser et al.
Summary: A survey study in the Netherlands found that 73% of youth aged 12-18 were willing to get vaccinated against COVID-19. Vaccination willingness was strongly related to age, perceived personal and societal benefits, and peers' and parents' vaccination uptake. Negative associations were found with perceived side-effects and potential long term consequences.
Article
Immunology
W. H. S. Wong et al.
Summary: This survey study explores the attitudes of Hong Kong adolescents towards COVID-19 vaccination, and finds that adolescents' intent to vaccinate is influenced by their parents' vaccination status, knowing someone diagnosed with COVID-19, and receiving the influenza vaccine. Safety and efficacy concerns as well as risk of infection are major factors contributing to vaccine hesitancy among adolescents.
Article
Cardiac & Cardiovascular Systems
Deborah Foltran et al.
Summary: This study aimed to investigate the risk of reporting pericarditis and/or myocarditis after mRNA COVID-19 vaccination in adolescents aged 12-17 years. The study found that the second dose of mRNA COVID-19 vaccine was associated with an increased risk of reporting pericarditis and/or myocarditis compared to the first dose, particularly in boys. There was no significant difference in risk between the two types of vaccines.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Raffaella Mormile
Summary: Recent reports have highlighted rare cases of myocarditis and pericarditis in male adolescents and young adults following COVID-19 mRNA vaccination. The development of acute myocarditis and pericarditis in these individuals may be attributed to age-related lower levels of T-bet and PD-1, predisposing them to autoreactive CD8+CTL release due to T-bet polymorphism. The higher incidence of myocarditis or pericarditis in men compared to women could potentially be explained by estrogen-induced upregulation of T-Bet and PD-1.
EXPERT REVIEW OF CARDIOVASCULAR THERAPY
(2022)
Article
Medicine, General & Internal
Kimberly H. Nguyen et al.
Summary: Between June and October 2021, there was a five-fold increase in COVID-19 hospitalization cases among children and adolescents. However, adolescent COVID-19 vaccination coverage has plateaued in the United States. The study analyzed trends in COVID-19 vaccination among adolescents ages 12-17, parental intention to vaccinate their children, and reasons for not intending to vaccinate from July to October 2021. Results showed a five percentage point increase in vaccination coverage among adolescents, but no significant changes in parental intention. Approximately one quarter of parents expressed uncertainty or reluctance to vaccinate their children. Lack of trust in the government and vaccines, as well as the belief that the vaccine is unnecessary or ineffective, were higher in October compared to July among parents who had not vaccinated their children.
ANNALS OF MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Onyedika J. Ilonze et al.
Summary: The clinical course and outcomes of myocarditis after COVID-19 vaccination vary. Retrospective data collection on 238 patients diagnosed with myocarditis within 60 days of mRNA vaccination showed that females presented at older ages and patients over 20 years old had a longer duration from vaccination to symptoms.
HEART FAILURE REVIEWS
(2022)
Letter
Pediatrics
Li Xue et al.
Article
Immunology
Francisco Tsz Tsun Lai et al.
Summary: A retrospective cohort study found that the risk of adverse events following BNT162b2 vaccination in adolescents aged 12-18 is not significantly increased, except for myocarditis and sleeping disturbances after the second dose.
EMERGING MICROBES & INFECTIONS
(2022)
Review
Immunology
Peng Gao et al.
Summary: According to the study, SARS-CoV-2 vaccines have shown good effectiveness and safety in children and adolescents. Vaccinating them can help protect against COVID-19 and slow the spread of the pandemic.
Article
Public, Environmental & Occupational Health
Micah B. Hahn et al.
Summary: The COVID-19 vaccine acceptance rate in remote Alaskan communities has been increasing, with 80.7% of participants reporting having received or planning to receive the vaccine. Despite initial concerns, most residents' attitudes towards vaccination have shifted over time.
INTERNATIONAL JOURNAL OF CIRCUMPOLAR HEALTH
(2022)
Editorial Material
Medicine, General & Internal
Tom Shimabukuro et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Salvatore Pepe et al.
HEART LUNG AND CIRCULATION
(2021)
Article
Medicine, General & Internal
D. Mevorach et al.
Summary: The incidence of myocarditis increased after receiving the BNT162b2 vaccine in Israel, particularly after the second dose among young male recipients. The clinical presentation of myocarditis after vaccination was usually mild.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Review
Immunology
Diane Gubernot et al.
Summary: The COVID-19 pandemic has led to global collaborative efforts to develop vaccines, with mass vaccination campaigns underway in multiple countries. Monitoring vaccine safety and understanding background incidence rates are crucial for assessing adverse events related to vaccination.
Article
Cardiac & Cardiovascular Systems
Biykem Bozkurt et al.
Summary: Myocarditis is a rare complication of COVID-19 mRNA vaccines, predominantly affecting young adult and adolescent males, with most patients showing improvement in symptoms. Possible mechanisms include molecular mimicry between viral proteins and self-antigens, dysregulated immune pathways, immune response to mRNA, and dysregulated cytokine expression.
Article
Pediatrics
Supriya S. Jain et al.
Summary: This study aimed to characterize the clinical presentation, short-term prognosis, and myocardial tissue changes in pediatric patients with C-VAM. The results showed that most patients had mild myocarditis and excellent short-term outcomes, with resolution of symptoms, arrhythmias, and ventricular dysfunction. Further studies are needed to understand the long-term implications of these myocardial tissue changes.
Article
Biotechnology & Applied Microbiology
Xiao Wan et al.
Summary: The study indicates that the majority of Chinese parents of 3-6 year old children are willing to vaccinate their children against COVID-19. Factors such as being female, recognizing their children in high-risk category, actively seeking vaccine-related information, believing in the safety of the vaccine, and understanding the preventive capabilities of the vaccine are associated with higher willingness to vaccinate their children.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Article
Public, Environmental & Occupational Health
Julia W. Gargano et al.
MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT
(2021)
Article
Immunology
Sarah Musa et al.
Summary: The study found that key factors influencing parental vaccine hesitancy towards the COVID-19 vaccine for 12-15 year olds include the adolescents' age, parents' nationality, and history of COVID-19 infection. Effective communication strategies targeting parents of younger adolescents, those from Gulf Countries, and parents of adolescents with chronic diseases or previous COVID-19 infection are crucial to increase vaccine uptake and build community trust.
Article
Medicine, General & Internal
Florence T. Bourgeois et al.
Summary: This retrospective cohort study analyzed hospitalized pediatric patients with COVID-19 in 6 countries, highlighting variability in hospitalization trends across countries as well as identifying common complications and laboratory abnormalities in infected children and youth.
Article
Pediatrics
Giuseppe Calcaterra et al.
Summary: Health regulators in the US and Europe are investigating the potential link between COVID-19 mRNA vaccines and myocarditis in adolescent males. There is currently no evidence to suggest that these cases of heart inflammation are related to other diseases.
Article
Medicine, General & Internal
Hwanhee Park et al.
Summary: The study found that the frequency of myocarditis/pericarditis was highest among male adolescent inpatients in Korea, with a male to female ratio of 3.2 in the 12-17 age group. Most patients required pediatric intensive care unit care, and some needed heart medication upon discharge. The mortality rate was low overall, but higher among adolescent patients.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2021)
Article
Cardiac & Cardiovascular Systems
Anita Arola et al.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2017)
Article
Medicine, General & Internal
David Moher et al.
ANNALS OF INTERNAL MEDICINE
(2009)
