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Article
Biochemistry & Molecular Biology
Wilfredo F. Garcia-Beltran et al.
Summary: Recent surveillance has identified the emergence of the SARS-CoV-2 Omicron variant, which carries up to 36 mutations in the spike protein and has the potential to evade vaccine-induced immunity. This study found that individuals vaccinated with mRNA vaccines exhibited strong neutralization of the Omicron variant, while most vaccinees had weak neutralization. The study also revealed that the Omicron variant infects more efficiently than other tested variants.
Article
Urology & Nephrology
Khalil El Karoui et al.
Summary: This study suggests that vaccination may provide a protective effect against severe forms of COVID-19 in dialysis patients, despite their altered immunologic responses to vaccines.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Urology & Nephrology
Ori Wand et al.
Summary: Breakthrough COVID-19 can occur in vaccinated individuals, particularly with the Delta variant. COVID-19 infection in hemodialysis patients is associated with immunosuppression and lower antibody levels after vaccination, leading to severe disease and higher mortality rates.
JOURNAL OF NEPHROLOGY
(2022)
Article
Urology & Nephrology
Maxime Espi et al.
Summary: The level of protection provided by two doses of COVID-19 mRNA vaccines in patients receiving maintenance hemodialysis (MHD) is uncertain. This study found that vaccination significantly reduced the incidence and severity of COVID-19, but 11% of patients infected after two doses still died. Lack of protection in SARS-CoV-2-naive patients could be due to defective T-cell response and failure to generate sufficient neutralizing antibodies after vaccination. Administering a third dose of vaccine improved protection in low/no responders. High responders did not show an increase in antibodies after the third dose but experienced more side effects. The antibody and T-cell response after two doses can guide personalized administration of the third dose in MHD patients.
KIDNEY INTERNATIONAL
(2022)
Letter
Medicine, General & Internal
Edward J. Carr et al.
Article
Biochemistry & Molecular Biology
Paul R. Wratil et al.
Summary: This study reports on the dynamics of neutralizing antibodies in individuals convalescing from coronavirus disease 2019 or who are vaccine-naive and subsequently vaccinated. The findings suggest that infection-plus-vaccination-induced hybrid immunity or triple immunization can induce high-quality antibodies with superior neutralization capacity against variants of concern, including omicron.
Article
Transplantation
Borja Quiroga et al.
Summary: This study aims to describe the humoral response and safety of COVID-19 vaccines in CKD patients. The results show that most CKD patients develop antibodies after vaccination, but kidney transplant patients have a lower antibody response rate, suggesting the need for additional isolation measures and booster doses of the vaccine.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Medicine, General & Internal
Nabil Ahmed et al.
Summary: This study examined the incidence, epidemiological characteristics, and mortality rate of COVID-19 among maintenance dialysis patients in Palestine. The study found a notably high incidence of COVID-19 among dialysis patients, particularly among those on hemodialysis. High rates of hospitalization, ICU admission, intubation, and death were observed. Age, gender, smoking, diabetes, and the use of central venous catheters for hemodialysis were identified as predictive factors for COVID-19-related mortality. Strict infection control measures and promotion of home dialysis are necessary to reduce the risk of infection.
ANNALS OF MEDICINE
(2022)
Letter
Urology & Nephrology
Borja Quiroga et al.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Letter
Urology & Nephrology
Okan Cinkilic et al.
KIDNEY INTERNATIONAL
(2022)
Letter
Urology & Nephrology
Moritz Anft et al.
KIDNEY INTERNATIONAL
(2022)
Article
Urology & Nephrology
Jean-Francois Verdier et al.
Summary: This study aimed to investigate the humoral response of haemodialysis patients who received the BNT162b2 mRNA vaccine. The results showed that patients who received two doses of the vaccine might not have sufficient humoral protection against SARS-CoV-2 and should receive a third (booster) dose.
Article
Rheumatology
Luuk Wieske et al.
Summary: Specific immunosuppressants may impair humoral responses after SARS-CoV-2 vaccination. Most patients receiving immunosuppressant therapy show similar humoral responses to controls after standard vaccination, although antibody titres may be moderately reduced. However, a third vaccination can enhance immune responses in patients with poor humoral responses.
LANCET RHEUMATOLOGY
(2022)
Article
Immunology
Johanna Erber et al.
Summary: This study investigated the prevalence of SARS-CoV-2 infection in hospital staff in Munich, Germany and found that staff engaged in direct patient care had a similar probability of being seropositive as non-patient-facing staff. Increased risk of infection was observed in staff who had interactions with infected coworkers or private contacts, as well as those who had exposure to COVID-19 patients without appropriate personal protective equipment. The study also identified that the infection hotspots for SARS-CoV-2-positive staff and patients only partially overlapped.
EMERGING INFECTIOUS DISEASES
(2022)
Article
Multidisciplinary Sciences
Nina Koerber et al.
Summary: Anti-viral immunity declines over time after SARS-CoV-2 infection, but convalescents can achieve enhanced immune response through vaccination. Virus-specific antibody titers decline rapidly, while virus-specific polyfunctional T cells persist.
NATURE COMMUNICATIONS
(2022)
Article
Medicine, General & Internal
Kwok-Hung Chan et al.
Summary: The study evaluated the performance of a surrogate SARS-CoV-2 NAb assay compared to the live virus microneutralization assay. The results showed high concordance between the surrogate assay and the traditional method in naturally infected individuals and vaccine recipients. The iFlash RBD NAb assay was found to be sensitive and reliable for measuring neutralizing antibodies in patients with COVID-19 and vaccinated individuals.
Article
Biochemistry & Molecular Biology
David S. Khoury et al.
Summary: The level of neutralizing antibodies is closely related to immune protection against COVID-19, playing a crucial role in protecting against detected infection and severe infection. Studies have shown that neutralizing titers will decline over time after vaccination, leading to decreased protection against SARS-CoV-2 infection.
Review
Food Science & Technology
Maxime Espi et al.
Article
Transplantation
Luuk B. Hilbrands et al.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2020)