☆ 4.5 Review

Air pollution, metabolites and respiratory health across the life-course

EUROPEAN RESPIRATORY REVIEW (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Environmental Sciences

Child serum metabolome and traffic-related air pollution exposure in pregnancy

Beate Ritz et al.

Summary: This study investigated the metabolic effects of air pollution exposure during pregnancy on neonates and found that neonates exposed to air pollution exhibit alterations in oxidative stress and inflammation pathways related to lipid metabolism.

ENVIRONMENTAL RESEARCH (2022)

添加到收藏夹

Article Respiratory System

Urinary metabotype of severe asthma evidences decreased carnitine metabolism independent of oral corticosteroid treatment in the U-BIOPRED study

Stacey N. Reinke et al.

Summary: This study investigates the impact of asthma severity and medication on metabolic processes using metabolomics analysis. The results reveal dysregulated metabolism in severe asthma, with differences observed between OCS-treated and non-treated patients. Altered carnitine metabolism is associated with mitochondrial dysfunction in severe asthma and is independent of OCS treatment.

EUROPEAN RESPIRATORY JOURNAL (2022)

添加到收藏夹

Article Engineering, Environmental

Dynamic molecular choreography induced by traffic exposure: A randomized, crossover trial using multi-omics profiling

Xihao Du et al.

Summary: The study conducted a randomized, crossover trial among healthy young students in Shanghai, China to investigate the biological mechanism of adverse health outcomes related to traffic-related air pollution (TRAP). The multi-omics analysis showed that exposure to TRAP is associated with changes in genome-wide transcription, protein, and metabolite profiles, affecting pathways such as inflammation, oxidative stress, and hormone signaling. The study demonstrated novel pathways activated in response to TRAP exposure, providing evidence of global molecular changes at the multi-omics level.

JOURNAL OF HAZARDOUS MATERIALS (2022)

添加到收藏夹

Article Respiratory System

Obesity, tidal volume, and pulmonary deposition of fine particulate matter in children with asthma

Nima Afshar-Mohajer et al.

Summary: A study found that obese children with asthma breathe at higher tidal volumes, leading to higher deposition rates of air pollutant PM2.5 in the lungs. This may partially explain why obese children with asthma are more sensitive to air pollution.

EUROPEAN RESPIRATORY JOURNAL (2022)

添加到收藏夹

Article Critical Care Medicine

Pathogenesis of chronic obstructive pulmonary disease: understanding the contributions of gene-environment interactions across the lifespan

Alva Agusti et al.

Summary: Recent research findings challenge the traditional view of chronic obstructive pulmonary disease (COPD) as solely caused by smoking in genetically susceptible individuals. Instead, COPD is now understood as the potential end result of gene-environment interactions accumulated over an individual's lifetime. Future research should aim to understand the dynamic interactions between genes and the environment by integrating information from basic and clinical omics with exposures over time. Additionally, COPD should be viewed as a clinical syndrome rather than a single disease.

LANCET RESPIRATORY MEDICINE (2022)

添加到收藏夹

Article Environmental Sciences

Integration of gene expression and DNA methylation identifies epigenetically controlled modules related to PM2.5 exposure

Simon Kebede Merid et al.

Summary: Exposure to PM2.5 at birth was found to be associated with differential gene expression in children and adolescents. Additionally, gene modules related to complex diseases were identified in relation to PM2.5 exposure.

ENVIRONMENT INTERNATIONAL (2021)

添加到收藏夹

Article Environmental Sciences

Metabolomic signatures of the long-term exposure to air pollution and temperature

Feiby L. Nassan et al.

Summary: Using a global untargeted metabolomic approach, this study identified significant metabolites and metabolic pathways associated with long-term exposure to PM2.5, NO2, and temperature. This is the largest metabolomics study on long-term air pollution to date, the first to report a metabolic signature of long-term temperature exposure, and the first to use independent component analysis (ICA) in the analysis.

ENVIRONMENTAL HEALTH (2021)

添加到收藏夹

Article Environmental Sciences

Metabolomics identifying biomarkers of PM2.5 exposure for vulnerable population: based on a prospective cohort study

Haiyan Chu et al.

Summary: This study found that long-term exposure to PM2.5 may lead to disturbances in phospholipid metabolism, and LysoPC (P-20:0) and LysoPC (P-18:1(9z)) may serve as biomarkers for PM2.5 exposure.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2021)

添加到收藏夹

Article Respiratory System

Long-term exposure to low-level air pollution and incidence of asthma: the ELAPSE project

Shuo Liu et al.

Summary: Long-term exposure to PM2.5, NO2, and BC air pollutants was associated with an increased risk of adult-onset asthma, even at levels below current limit values. Adjusted for potential confounders, the associations were significant.

EUROPEAN RESPIRATORY JOURNAL (2021)

添加到收藏夹

Article Environmental Sciences

Periconception air pollution, metabolomic biomarkers, and fertility among women undergoing assisted reproduction

Audrey J. Gaskins et al.

Summary: Research indicates that periconception air pollution exposure can affect women's metabolic changes, potentially mediating the impact of air pollution on fertility through pathways involving inflammation and oxidative stress.

ENVIRONMENT INTERNATIONAL (2021)

添加到收藏夹

Article Environmental Sciences

Metabolomic signatures of the short-term exposure to air pollution and temperature

Feiby L. Nassan et al.

Summary: This study is the first to report an untargeted metabolomic signature related to temperature exposure, the largest study to date on untargeted metabolomic signature of air pollution, and the first to use ICA. Short-term exposure to air pollution and temperature can affect several important plasma metabolites and metabolic pathways, involving inflammation and oxidative stress, immunity, and nucleic acid damage and repair.

ENVIRONMENTAL RESEARCH (2021)

添加到收藏夹

Editorial Material Respiratory System

Clean air for healthy lungs - an urgent call to action: European Respiratory Society position on the launch of the WHO 2021 Air Quality Guidelines

Zorana Jovanovic Andersen et al.

EUROPEAN RESPIRATORY JOURNAL (2021)

添加到收藏夹

Article Critical Care Medicine

Characteristics and Mechanisms of a Sphingolipid-associated Childhood Asthma Endotype

Daniela Rago et al.

Summary: This study explored a childhood asthma endotype characterized by reduced sphingolipid concentrations, early onset, and increased airway resistance. Lower concentrations of ceramides and sphingomyelins at 6 months correlated with an increased asthma risk before age 3, while reduced levels of key phosphosphingolipids at age 6 were associated with higher airway resistance. These associations were influenced by the 17q21 genotype and nasal gene expression of SPT.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Hallmarks of environmental insults

Annette Peters et al.

Summary: Environmental insults such as contaminated air, water, and food expose human beings to a plethora of chemicals and stressors, impacting health at all stages of life. The proposed eight hallmarks of environmental insults encompass oxidative stress, genomic alterations, epigenetic changes, and disruptions to various bodily functions, offering insight into the severe health effects induced by complex mixtures of environmental exposures.

CELL (2021)

添加到收藏夹

Article Environmental Sciences

Application of high-resolution metabolomics to identify biological pathways perturbed by traffic-related air pollution

Zhenjiang Li et al.

Summary: The study examined metabolic perturbations associated with short-term exposures to traffic-related air pollutants using high-resolution metabolomics. Results revealed that pollutants like nitrogen dioxide and elemental carbon are consistently associated with pathways related to nucleic acids damage/repair, nutrient metabolism, and acute inflammation.

ENVIRONMENTAL RESEARCH (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Application of Metabolomics in Pediatric Asthma: Prediction, Diagnosis and Personalized Treatment

Maria Michelle Papamichael et al.

Summary: Pediatric asthma is a major public health challenge, affecting 5-20% of children in Europe and attributed to genetic susceptibility and environmental factors. Metabolomics, as an emerging approach, can provide deeper insight into the pathophysiological mechanisms of asthma, facilitate the discovery of early diagnostic markers and personalized therapies. Analyzing intermediate metabolites in clinical practice may have a positive impact on pediatric asthma management.

METABOLITES (2021)

添加到收藏夹

Article Environmental Sciences

Fine particulate matter exposure and perturbation of serum metabolome: A longitudinal study in Baoding, China

Shu Huan et al.

Summary: A study on 63 healthy college students revealed that exposure to PM2.5 has significant effects on serum metabolomics, particularly impacting metabolic signaling related to oxidative stress and inflammation. Males may be more susceptible to these metabolic perturbations induced by higher PM2.5 exposure.

CHEMOSPHERE (2021)

添加到收藏夹

Article Environmental Sciences

Ambient PM2.5 species and ultrafine particle exposure and their differential metabolomic signatures

Feiby L. Nassan et al.

Summary: This study aimed to determine the relative contribution of different species of PM2.5 exposure to perturbed metabolic pathways. Results showed that specific PM2.5 species were associated with inflammation, oxidative stress, immunity, and nucleic acid damage and repair in plasma metabolites. These findings highlight the importance of considering specific sources of PM2.5 exposure in understanding its impact on metabolic pathways.

ENVIRONMENT INTERNATIONAL (2021)

添加到收藏夹

Article Environmental Sciences

Perturbation of amino acid metabolism mediates air pollution associated vascular dysfunction in healthy adults

Baihuan Feng et al.

Summary: The study investigated the effects of ambient air pollution on vascular function in 73 healthy adults living in Beijing between 2014 and 2016, highlighting the potential mediation effects of amino acids. Results showed that amino acids might mediate up to 48% of the changes in sICAM-1 associated with increased air pollution exposure, indicating that air pollution could prompt vascular dysfunction through perturbing amino acid metabolism.

ENVIRONMENTAL RESEARCH (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Global metabolome profiling of exhaled breath condensates in male smokers with asthma COPD overlap and prediction of the disease

Nilanjana Ghosh et al.

Summary: ACO patients have a distinct metabolic profile in exhaled breath condensate compared to asthma and COPD, which can serve as non-invasive biomarkers for differentiation. These metabolites can be used to establish a robust classification model for ACO.

SCIENTIFIC REPORTS (2021)

添加到收藏夹

Article Engineering, Environmental

Defining the Scope of Exposome Studies and Research Needs from a Multidisciplinary Perspective

Pei Zhang et al.

Summary: The concept of the exposome emphasizes the impact of the environment on health and disease, expanding from exposure assessment to include biological responses. From an international and multidisciplinary perspective, integration, standardization, and large investments are key to advancing exposomics.

ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Potential Metabolic Biomarkers in Adult Asthmatics

Soyoon Sim et al.

Summary: Asthma is a common chronic airway inflammation with multiple phenotypes caused by interactions of genetic, epigenetic, and environmental factors. Various determinants including genomics, transcriptomics, proteomics, and metabolomics may impact the pathogenesis of asthma. Lipid metabolism, particularly sphingolipid metabolites, has been suggested to play a role in lung dysfunction in asthma, specifically in obese asthma and aspirin-exacerbated respiratory disease.

METABOLITES (2021)

添加到收藏夹

Article Environmental Sciences

Developing the building blocks to elucidate the impact of the urban exposome on cardiometabolic-pulmonary disease: The EU EXPANSE project

Jelle Vlaanderen et al.

Summary: The EXPANSE project aims to study the impact of the urban exposome on major diseases in Europe, achieve personalized exposome assessment, evaluate the evolution of exposome and health, and assess the impact of changes in the urban exposome on disease burden.

ENVIRONMENTAL EPIDEMIOLOGY (2021)

添加到收藏夹

Article Respiratory System

Assessment of chronic bronchitis and risk factors in young adults: results from BAMSE

Gang Wang et al.

Summary: The prevalence of chronic bronchitis in young adults is 5.5%, with recurrent respiratory infections being a key factor. Besides smoking, factors such as air pollution exposure and exclusive breastfeeding are also associated with chronic bronchitis.

EUROPEAN RESPIRATORY JOURNAL (2021)

添加到收藏夹

Article Public, Environmental & Occupational Health

Use of Untargeted Metabolomics to Explore the Air Pollution-Related Disease Continuum

Lan Jin et al.

Summary: This review summarizes the application of untargeted metabolomics in identifying metabolic perturbations associated with air pollutant exposures, showing a link between air pollution and metabolic pathways related to oxidative stress and inflammation across various populations. More comprehensive metabolomic studies with larger sample sizes are needed to further explore the mechanisms of susceptibility in subpopulations and the specific adverse health effects of air pollution exposure.

CURRENT ENVIRONMENTAL HEALTH REPORTS (2021)

添加到收藏夹

Review Respiratory System

Metabolomics in chronic lung diseases

Shabarinath Nambiar et al.

RESPIROLOGY (2020)

添加到收藏夹

Editorial Material Respiratory System

The role of gene-environment interactions in lung disease: the urgent need for the exposome

Craig E. Wheelock et al.

EUROPEAN RESPIRATORY JOURNAL (2020)

添加到收藏夹

Editorial Material Public, Environmental & Occupational Health

Long-term effects of air pollution: an exposome meet-in-the-middle approach

Paolo Vineis et al.

INTERNATIONAL JOURNAL OF PUBLIC HEALTH (2020)

添加到收藏夹

Review Multidisciplinary Sciences

The exposome and health: Where chemistry meets biology

Roel Vermeulen et al.

SCIENCE (2020)

添加到收藏夹

Article Respiratory System

Sphingolipid, fatty acid and phospholipid metabolites are associated with disease severity and mTOR inhibition in lymphangioleiomyomatosis

Leonardo Bottolo et al.

THORAX (2020)

添加到收藏夹

Article Critical Care Medicine

Asthma genetics revisited: understanding disease mechanisms by studying ethnically diverse groups

Erik Melén

Lancet Respiratory Medicine (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Identifying Protein-metabolite Networks Associated with COPD Phenotypes

Emily Mastej et al.

METABOLITES (2020)

添加到收藏夹

Article Environmental Sciences

Genome-Wide DNA Methylation in Peripheral Blood and Long-Term Exposure to Source -Specific Transportation Noise and Air Pollution: The SAPALDIA Study

Ikenna C. Eze et al.

ENVIRONMENTAL HEALTH PERSPECTIVES (2020)

添加到收藏夹

Article Critical Care Medicine

Chronic obstructive pulmonary disease and related phenotypes: polygenic risk scores in population-based and case-control cohorts

Matthew Moll et al.

Lancet Respiratory Medicine (2020)

添加到收藏夹

Article Respiratory System

A cross-omics integrative study of metabolic signatures of chronic obstructive pulmonary disease

Ivana Prokic et al.

BMC PULMONARY MEDICINE (2020)

添加到收藏夹

Review Public, Environmental & Occupational Health

Air Pollution and Adverse Pregnancy and Birth Outcomes: Mediation Analysis Using Metabolomic Profiles

Kosuke Inoue et al.

CURRENT ENVIRONMENTAL HEALTH REPORTS (2020)

添加到收藏夹

Article Respiratory System

Metabolomic fingerprinting and systemic inflammatory profiling of asthma COPD overlap (ACO)

Nilanjana Ghosh et al.

RESPIRATORY RESEARCH (2020)

添加到收藏夹

Article Respiratory System

Outdoor Air Pollution and New-Onset Airway Disease An Official American Thoracic Society Workshop Report

George D. Thurston et al.

ANNALS OF THE AMERICAN THORACIC SOCIETY (2020)

添加到收藏夹

Review Medicine, Research & Experimental

Environmental exposures and mechanisms in allergy and asthma development

Liza Bronner Murrison et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

添加到收藏夹

Article Allergy

Linking COPD epidemiology with pediatric asthma care: Implications for the patient and the physician

Erik Melen et al.

PEDIATRIC ALLERGY AND IMMUNOLOGY (2019)

添加到收藏夹

Review Critical Care Medicine

Lung function trajectories in health and disease

Alvar Agusti et al.

LANCET RESPIRATORY MEDICINE (2019)

添加到收藏夹

Article Environmental Sciences

Perturbations of the arginine metabolome following exposures to traffic-related air pollution in a panel of commuters with and without asthma

Donghai Liang et al.

ENVIRONMENT INTERNATIONAL (2019)

添加到收藏夹

Article Environmental Sciences

Prenatal Particulate Air Pollution and DNA Methylation in Newborns: An Epigenome-Wide Meta-Analysis

Olena Gruzieva et al.

ENVIRONMENTAL HEALTH PERSPECTIVES (2019)

添加到收藏夹

Article Endocrinology & Metabolism

Metabolomic signatures of asthma-COPD overlap (ACO) are different from asthma and COPD

Nilanjana Ghosh et al.

METABOLOMICS (2019)

添加到收藏夹

Article Multidisciplinary Sciences

The mediating effect of immune markers on the association between ambient air pollution and adult-onset asthma

Nahid Mostafavi et al.

SCIENTIFIC REPORTS (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

Bronchoalveolar Lavage Fluid from COPD Patients Reveals More Compounds Associated with Disease than Matched Plasma

Eitan Halper-Stromberg et al.

METABOLITES (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

Metabolomics Identifies Novel Blood Biomarkers of Pulmonary Function and COPD in the General Population

Bing Yu et al.

METABOLITES (2019)

添加到收藏夹

Article Environmental Sciences

Urine metabolites associated with cardiovascular effects from exposure of size-fractioned particulate matter in a subway environment: A randomized crossover study

Yannan Zhang et al.

ENVIRONMENT INTERNATIONAL (2019)

添加到收藏夹

Article Environmental Sciences

Oxidative stress and inflammation mediate the effect of air pollution on cardio- and cerebrovascular disease: A prospective study in nonsmokers

Giovanni Fiorito et al.

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS (2018)

添加到收藏夹

Article Critical Care Medicine

An Integrative Transcriptomic and Metabolomic Study of Lung Function in Children With Asthma

Rachel S. Kelly et al.

CHEST (2018)

添加到收藏夹

Article Respiratory System

Increased urinary L-histidine in patients with asthma COPD overlap: a pilot study

Jee Youn Oh et al.

INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (2018)

添加到收藏夹

Article Respiratory System

Air pollution exposure and lung function until age 16 years: the PIAMA birth cohort study

Edith B. Milanzi et al.

EUROPEAN RESPIRATORY JOURNAL (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Metabolomics and transcriptomics pathway approach reveals outcome-specific perturbations in COPD

Charmion I. Cruickshank-Quinn et al.

SCIENTIFIC REPORTS (2018)

添加到收藏夹

Article Environmental Sciences

Epigenome-Wide Meta-Analysis of Methylation in Children Related to Prenatal NO2 Air Pollution Exposure

Olena Gruzieva et al.

ENVIRONMENTAL HEALTH PERSPECTIVES (2017)

添加到收藏夹

Article Environmental Sciences

Linking sources to early effects by profiling urine metabolome of residents living near oil refineries and coal-fired power plants

Chi-Hsin Sally Chen et al.

ENVIRONMENT INTERNATIONAL (2017)

添加到收藏夹

Article Environmental Sciences

Exposure to Traffic-Related Air Pollution and Serum Inflammatory Cytokines in Children

Olena Gruzieva et al.

ENVIRONMENTAL HEALTH PERSPECTIVES (2017)

添加到收藏夹

Article Environmental Sciences

The impact of ambient air pollution on the human blood metabolome

J. J. Vlaanderen et al.

ENVIRONMENTAL RESEARCH (2017)

添加到收藏夹

Article Medicine, General & Internal

Estimates and 25-year trends of the global burden of disease attributable to ambient air pollution: an analysis of data from the Global Burden of Diseases Study 2015

Aaron J. Cohen et al.

LANCET (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Hippurate as a metabolomic marker of gut microbiome diversity: Modulation by diet and relationship to metabolic syndrome

Tess Pallister et al.

SCIENTIFIC REPORTS (2017)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Particulate Matter Exposure and Stress Hormone Levels A Randomized, Double-Blind, Crossover Trial of Air Purification

Huichu Li et al.

CIRCULATION (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Metabolomic profiling of lung function in Costa-Rican children with asthma

Rachel S. Kelly et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2017)

添加到收藏夹

Review Allergy

Effects of Long-Term Exposure to Traffic-Related Air Pollution on Lung Function in Children

Erica S. Schultz et al.

CURRENT ALLERGY AND ASTHMA REPORTS (2017)

添加到收藏夹

Article Critical Care Medicine

Genome-Wide Interaction Analysis of Air Pollution Exposure and Childhood Asthma with Functional Follow-up

Anna Gref et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Peptides in Bronchoalveolar Lavage in Chronic Obstructive Pulmonary Disease

Chris H. Wendt et al.

PLOS ONE (2016)

添加到收藏夹

Article Chemistry, Multidisciplinary

Metabolic alterations in the sera of Chinese patients with mild persistent asthma: a GC-MS-based metabolomics analysis

Chun Chang et al.

ACTA PHARMACOLOGICA SINICA (2015)

添加到收藏夹

Letter Critical Care Medicine

Circulating Levels of Antioxidant Vitamins Correlate with Better Lung Function and Reduced Exposure to Ambient Pollution

Cristina Menni et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2015)

添加到收藏夹

Article Medicine, General & Internal

Lung-Function Trajectories Leading to Chronic Obstructive Pulmonary Disease

Peter Lange et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

添加到收藏夹

Article Biology

Causal Mediation Analysis with Multiple Mediators

R. M. Daniel et al.

BIOMETRICS (2015)

添加到收藏夹

Article Allergy

Childhood exposure to ambient polycyclic aromatic hydrocarbons is linked to epigenetic modifications and impaired systemic immunity in T cells

K. M. Hew et al.

CLINICAL AND EXPERIMENTAL ALLERGY (2015)

添加到收藏夹

Article Public, Environmental & Occupational Health

Metabolomic markers reveal novel pathways of ageing and early development in human populations

Cristina Menni et al.

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY (2013)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Meeting-in-the-middle using metabolic profiling - a strategy for the identification of intermediate biomarkers in cohort studies

Marc Chadeau-Hyam et al.

BIOMARKERS (2011)

添加到收藏夹

Article Biochemical Research Methods

1H Nuclear Magnetic Resonance Metabolomics Analysis Identifies Novel Urinary Biomarkers for Lung Function

Joseph L. McClay et al.

JOURNAL OF PROTEOME RESEARCH (2010)

添加到收藏夹

Article Statistics & Probability

Identification, Inference and Sensitivity Analysis for Causal Mediation Effects

Kosuke Imai et al.

STATISTICAL SCIENCE (2010)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.