期刊
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
卷 10, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fbioe.2022.945148
关键词
combretastatin A4 (CA4); mitoxantrone (MIT); metal-organic particles (MOPs); pH sensitive; synergistic effect
资金
- National Natural Science Foundation of China [81901221, 82001273]
- Natural Science Foundation of Hunan province [2021JJ41031]
A novel strategy for the preparation of metal-organic particle-based nanomedicine, with high drug loading and good targeting properties, has been developed. The in vivo experiments showed significantly enhanced antitumor efficiency and minimal side effects.
The strategy for dual drug-loaded nanomedicine with targeting properties was always complex. Herein, a novel strategy for the preparation of metal-organic particle-based nanomedicine has been developed, and combretastatin A4 (CA4) and mitoxantrone (MIT) loaded MOPs (CMMOPs) have been obtained. In this system, using merely Cu(II) as a bridge to connect and coordinate with the dual drugs has resulted in the CMMOPs possessing a fairly high drug load of almost 90%. Moreover, the coordination between Cu(II) and the drugs was stable at physiological pH but easily cleavable in the tumor acidic microenvironment, which would provide a good targeting property for CMMOPs. The in vivo experiments indicated that CMMOPs possessed a significantly enhanced antitumor efficiency with negligible side effects. The results suggest that CMMOPs could be a potential anticancer formulation for tumor-targeted drug delivery.
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