Surface polydopamine modification of bone defect repair materials: Characteristics and applications

Bone defects are a common challenge for clinical orthopedic surgeons. The existing bone defect repair materials are difficult to achieve satisfactory osseointegration between the material and the bone. Therefore, it is increasingly important to find effective methods to improve the integration of the materials with the bone and thus facilitate bone defect repair. Researchers have found that polydopamine (PDA) has a structure and properties similar to the adhesive proteins secreted by mussels in nature, with good biocompatibility, bioactivity, hydrophilicity, bio-adhesion and thermal stability. PDA is therefore expected to be used as a surface modification material for bone repair materials to improve the bonding of bone repair materials to the bone surface. This paper reviews research related to PDA-modified bone repair materials and looks at their future applications.

Automated summary

Bone defects pose a common challenge for orthopedic surgeons, as existing repair materials often fail to achieve satisfactory integration with the bone. Polydopamine (PDA) has been identified as a potential surface modification material for bone repair materials due to its similar structure and properties to natural adhesive proteins found in mussels. PDA exhibits good biocompatibility, bioactivity, hydrophilicity, bio-adhesion, and thermal stability, offering potential for improved bonding between bone repair materials and the bone surface.