期刊
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
卷 10, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fbioe.2022.898951
关键词
calcium sulfate; bioglass; magnesium; osteogenesis; bone reparation
资金
- National Key Scientific Instrument and Equipment Development Projects of China [2018YFC1106300]
A composite bone cement, cubic crystalline magnesium-doped calcium sulfate/bioglass (MgCS/BG), was prepared and found to have increased compressive strength and good bioactivity. It promotes the adhesion and differentiation of mesenchymal stem cells, and enhances bone defect repair and new bone formation.
Calcium sulfate (CS) bone cement has been shown to have good biocompatibility and can be used as a bone filler for repairing bone defects. However, its clinical application is limited due to its low compressive strength and weak bone repair activity. To this end, in this study, cubic crystalline magnesium-doped calcium sulfate (MgCS) was prepared and mixed with 45S5 bioglass (BG) to form a composite bone cement (MgCS/BG). The results show that cubic crystal calcium sulfate helps to increase the compressive strength of the composite bone cement to more than 60 MPa. More importantly, the obtained magnesium-doped composite bone cement can promote the adhesion and differentiation of mesenchymal stem cells and has good bioactivity. Through a skull defect model, it was found that MgCS/BG can significantly enhance bone defect repair and new bone formation. This new composite MgCS/BG is very promising for future translation into clinical applications.
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