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Effects of TGF-β1 and IL-1β on expression of ADAMTS enzymes and TIMP-3 in human intervertebral disc degeneration
Shi-Long Wang et al.
EXPERIMENTAL AND THERAPEUTIC MEDICINE (2013)
Conditional activation of β-catenin signaling in mice leads to severe defects in intervertebral disc tissue
Meina Wang et al.
ARTHRITIS AND RHEUMATISM (2012)
The association of lumbar intervertebral disc degeneration on magnetic resonance imaging with body mass index in overweight and obese adults: A population-based study
Dino Samartzis et al.
ARTHRITIS AND RHEUMATISM (2012)
Predictors of outcome after surgery with disc prosthesis and rehabilitation in patients with chronic low back pain and degenerative disc: 2-year follow-up
Christian Hellum et al.
EUROPEAN SPINE JOURNAL (2012)
Advances in Susceptibility Genetics of Intervertebral Degenerative Disc Disease
Yin'gang Zhang et al.
International Journal of Biological Sciences (2012)
Fracture of the vertebral endplates, but not equienergetic impact load, promotes disc degeneration in vitro
Stefan Dudli et al.
JOURNAL OF ORTHOPAEDIC RESEARCH (2012)
Interactions of environmental conditions and mechanical loads have influence on matrix turnover by nucleus pulposus cells
Cornelia Neidlinger-Wilke et al.
JOURNAL OF ORTHOPAEDIC RESEARCH (2012)
Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits
Jian Yang et al.
NATURE GENETICS (2012)
The ENCODE project
Natalie de Souza
NATURE METHODS (2012)
Lumbar intervertebral disc degeneration associated with axial and radiating low back pain in ageing SPARC-null mice
Magali Millecamps et al.
PAIN (2012)
Simulated-Physiological Loading Conditions Preserve Biological and Mechanical Properties of Caprine Lumbar Intervertebral Discs in Ex Vivo Culture
Cornelis P. L. Paul et al.
PLOS ONE (2012)
Association of the polymorphism of DR4 with the risk and severity of lumbar disc degeneration in the Chinese Han population
Haitao Tan et al.
SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION (2012)
Comparison of Animal Discs Used in Disc Research to Human Lumbar Disc Torsion Mechanics and Collagen Content
Brent L. Showalter et al.
SPINE (2012)
Genetics of the Degenerated Intervertebral Disc
Samuel Kalb et al.
WORLD NEUROSURGERY (2012)
Preparation of Intact Bovine Tail Intervertebral Discs for Organ Culture
Samantha C. W. Chan et al.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2012)
The association of aggrecan gene polymorphism with the risk of intervertebral disc degeneration
Nam Keun Kim et al.
ACTA NEUROCHIRURGICA (2011)
Progression of lumbar disc degeneration over a decade: a heritability study
Frances M. K. Williams et al.
ANNALS OF THE RHEUMATIC DISEASES (2011)
GDF5 Single-Nucleotide Polymorphism rs143383 Is Associated With Lumbar Disc Degeneration in Northern European Women
F. M. K. Williams et al.
ARTHRITIS AND RHEUMATISM (2011)
Association of FAS and FAS ligand polymorphisms with the susceptibility and severity of lumbar disc degeneration in Chinese Han population
Guang-bin Zhu et al.
BIOMARKERS (2011)
Genetic susceptibility of intervertebral disc degeneration among young Finnish adults
Anthi Kelempisioti et al.
BMC MEDICAL GENETICS (2011)
The effect of degenerative morphological changes of the intervertebral disc on the lumbar spine biomechanics: a poroelastic finite element investigation
Fabio Galbusera et al.
COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING (2011)
Caspase 9 gene polymorphism and susceptibility to lumbar disc disease in the Han population in northern China
Zheng-Ming Sun et al.
CONNECTIVE TISSUE RESEARCH (2011)
Interleukin-1β Induces Angiogenesis and Innervation in Human Intervertebral Disc Degeneration
Jae Man Lee et al.
JOURNAL OF ORTHOPAEDIC RESEARCH (2011)
Mechanical Loading Affects the Energy Metabolism of Intervertebral Disc Cells
Hanan N. Fernando et al.
JOURNAL OF ORTHOPAEDIC RESEARCH (2011)
Candidate Gene Association Study of Magnetic Resonance Imaging-based Hip Osteoarthritis (OA): Evidence for COL9A2 Gene as a Common Predisposing Factor for Hip OA and Lumbar Disc Degeneration
Annu Nakki et al.
JOURNAL OF RHEUMATOLOGY (2011)
Comparison of four methods to simulate swelling in poroelastic finite element models of intervertebral discs
Fabio Galbusera et al.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS (2011)
Complex loading affects intervertebral disc mechanics and biology
B. A. Walter et al.
OSTEOARTHRITIS AND CARTILAGE (2011)
Behavioral Signs of Chronic Back Pain in the SPARC-Null Mouse
Magali Millecamps et al.
SPINE (2011)
The involvement of interleukin-1 and interleukin-4 in the response of human annulus fibrosus cells to cyclic tensile strain: an altered mechanotransduction pathway with degeneration
Hamish T. J. Gilbert et al.
ARTHRITIS RESEARCH & THERAPY (2011)
The Effect of Sustained Compression on Oxygen Metabolic Transport in the Intervertebral Disc Decreases with Degenerative Changes
Andrea Malandrino et al.
PLOS COMPUTATIONAL BIOLOGY (2011)
Cartilage Intermediate Layer Protein Gene Is Associated With Lumbar Disc Degeneration in Male, but Not Female, Collegiate Athletes
Seok-Ki Min et al.
AMERICAN JOURNAL OF SPORTS MEDICINE (2010)
TNF-α and neuropathic pain - a review
Lawrence Leung et al.
JOURNAL OF NEUROINFLAMMATION (2010)
Hints of hidden heritability in GWAS
Greg Gibson
NATURE GENETICS (2010)
Expression of semaphorin 3A and its receptors in the human intervertebral disc: potential role in regulating neural ingrowth in the degenerate intervertebral disc
Sotonye K. Tolofari et al.
ARTHRITIS RESEARCH & THERAPY (2010)
Trait-Associated SNPs Are More Likely to Be eQTLs: Annotation to Enhance Discovery from GWAS
Dan L. Nicolae et al.
PLOS GENETICS (2010)
Modified Expression of the ADAMTS Enzymes and Tissue Inhibitor of Metalloproteinases 3 During Human Intervertebral Disc Degeneration
Aneta J. Pockert et al.
ARTHRITIS AND RHEUMATISM (2009)
Altered Integrin Mechanotransduction in Human Nucleus Pulposus Cells Derived From Degenerated Discs
Christine Lyn Le Maitre et al.
ARTHRITIS AND RHEUMATISM (2009)
Associations of 25 Structural, Degradative, and Inflammatory Candidate Genes With Lumbar Disc Desiccation, Bulging, and Height Narrowing
Tapio Videman et al.
ARTHRITIS AND RHEUMATISM (2009)
Association between the-1562 C/T Polymorphism of Matrix Metalloproteinase-9 Gene and Lumbar Disc Disease in the Young Adult Population in North China
Zheng-ming Sun et al.
CONNECTIVE TISSUE RESEARCH (2009)
Association of the Tag SNPs in the Human SKT Gene (KIAA1217) With Lumbar Disc Herniation
Tatsuki Karasugi et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2009)
Environmental Regulation of Notochordal Gene Expression in Nucleus Pulposus Cells
Anshu Rastogi et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2009)
The fate of bovine bone marrow stromal cells in hydrogels: a comparison to nucleus pulposus cells and articular chondrocytes
Stephan Zeiter et al.
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2009)
Sp1 Phosphorylation and Its Regulation of Gene Transcription
Nicole Y. Tan et al.
MOLECULAR AND CELLULAR BIOLOGY (2009)
Finding the missing heritability of complex diseases
Teri A. Manolio et al.
NATURE (2009)
Analysis of radial variations in material properties and matrix composition of chondrocyte-seeded agarose hydrogel constructs
T-A. N. Kelly et al.
OSTEOARTHRITIS AND CARTILAGE (2009)
A Continuous Observation of the Degenerative Process in the Intervertebral Disc of Smad3 Gene Knock-Out Mice
Chen-Guang Li et al.
SPINE (2009)
Prevalence and Pattern of Lumbar Magnetic Resonance Imaging Changes in a Population Study of One Thousand Forty-Three Individuals
Kenneth M. C. Cheung et al.
SPINE (2009)
A Phenotypic Comparison of Proteoglycan Production of Intervertebral Disc Cells Isolated from Rats, Rabbits, and Bovine Tails; Which Animal Model is Most Suitable to Study Tissue Engineering and Biological Repair of Human Disc Disorders?
Tsuyoshi Miyazaki et al.
TISSUE ENGINEERING PART A (2009)
Regulation of catabolic gene expression in normal and degenerate human intervertebral disc cells: implications for the pathogenesis of intervertebral disc degeneration
S. Jane Millward-Sadler et al.
ARTHRITIS RESEARCH & THERAPY (2009)
Expression of cartilage-derived morphogenetic protein in human intervertebral discs and its effect on matrix synthesis in degenerate human nucleus pulposus cells
Christine L. Le Maitre et al.
ARTHRITIS RESEARCH & THERAPY (2009)
Association of the asporin D14 allele with lumbar-disc degeneration in Asians
You-Qiang Song et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2008)
A functional polymorphism in THBS2 that affects alternative splicing and MMP binding is associated with lumbar-disc herniation
Yuichiro Hirose et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2008)
GraphCrunch: A tool for large network analyses
Tijana Milenkovic et al.
BMC BIOINFORMATICS (2008)
Regulation of Sp1 by cell cycle related proteins
Alicia Tapias et al.
CELL CYCLE (2008)
A porcine model of intervertebral disc degeneration induced by annular injury characterized with magnetic resonance imaging and histopathological findings
Seung-Hwan Yoon et al.
JOURNAL OF NEUROSURGERY-SPINE (2008)
Finite element analysis of the spine: Towards a framework of verification, validation and sensitivity analysis
Alison C. Jones et al.
MEDICAL ENGINEERING & PHYSICS (2008)
Investigation of the role of IL-1 and TNF in matrix degradation in the intervertebral disc
J. A. Hoyland et al.
RHEUMATOLOGY (2008)
Genetic factors are associated with Modic changes in endplates of lumbar vertebral bodies
Jaro Karppinen et al.
SPINE (2008)
Frequency-dependent behavior of the intervertebral disc in response to each of six degree of freedom dynamic loading - Solid phase and fluid phase contributions
John J. Costi et al.
SPINE (2008)
Comparison of animal discs used in disc research to human lumbar disc
Jesse C. Beckstein et al.
SPINE (2008)
Intervertebral disc cells as competent phagocytes in vitro: implications for cell death in disc degeneration
Philip Jones et al.
ARTHRITIS RESEARCH & THERAPY (2008)
Expression and regulation of neurotrophins in the nondegenerate and degenerate human intervertebral disc
Devina Purmessur et al.
ARTHRITIS RESEARCH & THERAPY (2008)
The influence of serum, glucose and oxygen on intervertebral disc cell growth in vitro: Implications for degenerative disc disease
William E. B. Johnson et al.
ARTHRITIS RESEARCH & THERAPY (2008)
Are animal models useful for studying human disc disorders/degeneration?
Mauro Alini et al.
EUROPEAN SPINE JOURNAL (2008)
Human cells derived from degenerate intervertebral discs respond differently to those derived from non-degenerate intervertebral discs following application of dynamic hydrostatic pressure
Christine Lyn Le Maitre et al.
BIORHEOLOGY (2008)
ISSLS prize winner: Repeated disc injury causes persistent inflammation
Jill A. Ulrich et al.
SPINE (2007)
A functional polymorphism in COL11A1, which encodes the α1 chain of type XI collagen, is associated with susceptibility to lumbar disc herniation
Futoshi Mio et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2007)
Influence of extracellular osmolarity and mechanical stimulation on gene expression of intervertebral disc cells
K. Wuertz et al.
JOURNAL OF ORTHOPAEDIC RESEARCH (2007)
Association between the-1306C/T polymorphism of matrix metalloproteinase-2 gene and lumbar disc disease in Chinese young adults
D. M. Dong et al.
EUROPEAN SPINE JOURNAL (2007)
Association between the aggrecan gene variable number of tandem repeats polymorphism and intervertebral disc degeneration
Svetlana Solovieva et al.
SPINE (2007)
Occupational and genetic risk factors associated with intervertebral disc disease
Iita M. Virtanen et al.
SPINE (2007)
Comparison of animals used in disc research to human lumbar disc geometry
Grace D. O'Connell et al.
SPINE (2007)
Catabolic cytokine expression in degenerate and herniated human intervertebral discs: IL-1 beta and TNF alpha expression profile
Christine Lyn Le Maitre et al.
ARTHRITIS RESEARCH & THERAPY (2007)
An in vitro organ culturing system for intervertebral disc explants with vertebral endplates -: A feasibility study with ovine caudal discs
Benjamin Gantenbein et al.
SPINE (2006)
TonEBP/OREBP is a regulator of nucleus pulposus cell function and survival in the intervertebral disc
Tsung-Ting Tsai et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
What is intervertebral disc degeneration, and what causes it?
Michael A. Adams et al.
SPINE (2006)
FANMOD: a tool for fast network motif detection
S Wernicke et al.
BIOINFORMATICS (2006)
Intervertebral disc degeneration in relation to the COL9A3 and the IL-1β gene polymorphisms
Svetlana Solovieva et al.
EUROPEAN SPINE JOURNAL (2006)
Histology and pathology of the human intervertebral disc
S Roberts et al.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME (2006)
Biologic modification of animal models of intervertebral disc degeneration
JW Larson et al.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME (2006)
Lumbar disc degeneration: Epidemiology and genetics
MC Battie et al.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME (2006)
Formation of a nucleus pulposus-cartilage endplate construct in vitro
DJ Hamilton et al.
BIOMATERIALS (2006)
Radiographic progression of lumbar spine disc degeneration is influenced by variation at inflammatory genes - A candidate SNP association study in the Chingford cohort
AM Valdes et al.
SPINE (2005)
MAVisto:: a tool for the exploration of network motifs
F Schreiber et al.
BIOINFORMATICS (2005)
A prospective, randomized, multicenter food and drug administration investigational device exemption study of lumbar total disc replacement with the CHARITE™ artificial disc versus lumbar fusion Part II:: Evaluation of radiographic outcomes and correlation of surgical technique accuracy with clinical outcomes
PC McAfee et al.
SPINE (2005)
A prospective, randomized, multicenter food and drug administration Investigational device exemptions study of lumbar total disc replacement with the CHARITE™ artificial disc versus lumbar fusion Part I:: Evaluation of clinical outcomes
S Blumenthal et al.
SPINE (2005)
Association of a COL1A1 polymorphism with lumbar disc disease in young military recruits -: art. no. e44
C Tilkeridis et al.
JOURNAL OF MEDICAL GENETICS (2005)
A functional SNP in CILP, encoding cartilage intermediate layer protein, is associated with susceptibility to lumbar disc disease
S Seki et al.
NATURE GENETICS (2005)
Human intervertebral disc aggrecan inhibits endothelial cell adhesion and cell migration In Vitro
WEB Johnson et al.
SPINE (2005)
Genetic variations in IL6 associate with intervertebral disc disease characterized by sciatica
N Noponen-Hietala et al.
PAIN (2005)
2004 Young Investigator Award winner: Vertebral endplate marrow contact channel occlusions and intervertebral disc degeneration
LM Benneker et al.
SPINE (2005)
The role of interleukin-1 in the pathogenesis of human intervertebral disc degeneration
CL Le Maitre et al.
ARTHRITIS RESEARCH & THERAPY (2005)
Expression and distribution of tumor necrosis factor alpha in human lumbar intervertebral discs: A study in surgical specimen and autopsy controls
C Weiler et al.
SPINE (2005)
VisANT: an online visualization and analysis tool for biological interaction data
ZJ Hu et al.
BMC BIOINFORMATICS (2004)
Experimental disc degeneration due to endplate injury
S Holm et al.
JOURNAL OF SPINAL DISORDERS & TECHNIQUES (2004)
Interleukin 1 polymorphisms and intervertebral disc degeneration
S Solovieva et al.
EPIDEMIOLOGY (2004)
TGF-β and TNF-α:: antagonistic cytokines controlling type I collagen gene expression
F Verrecchia et al.
CELLULAR SIGNALLING (2004)
Efficient sampling algorithm for estimating subgraph concentrations and detecting network motifs
N Kashtan et al.
BIOINFORMATICS (2004)
Effect of nutrient deprivation on the viability of intervertebral disc cells
SRS Bibby et al.
EUROPEAN SPINE JOURNAL (2004)
Lumbar disc degeneration -: Epidemiology and genetic influences
MC Battié et al.
SPINE (2004)
Animal models of intervertebral disc degeneration - Lessons learned
JC Lotz
SPINE (2004)
TopNet: a tool for comparing biological sub-networks, correlating protein properties with topological statistics
HY Yu et al.
NUCLEIC ACIDS RESEARCH (2004)
Collagen type I alpha 1 Sp1 polymorphism, osteoporosis, and intervertebral disc degeneration in older men and women
SMF Pluijm et al.
ANNALS OF THE RHEUMATIC DISEASES (2004)
Changes in vascularity of cartilage endplate of degenerated intervertebral discs in response to melatonin administration in rats
M Turgut et al.
NEUROSURGICAL REVIEW (2003)
The effect of cyclic compression on the mechanical properties of the inter-vertebral disc: An in vivo study in a rat tail model
CTS Ching et al.
CLINICAL BIOMECHANICS (2003)
Cytoscape: A software environment for integrated models of biomolecular interaction networks
P Shannon et al.
GENOME RESEARCH (2003)
Sequence variations in the collagen IX and XI genes are associated with degenerative lumbar spinal stenosis
N Noponen-Hietala et al.
ANNALS OF THE RHEUMATIC DISEASES (2003)
The role of the physicochemical environment in determining disc cell behaviour
JPG Urban
BIOCHEMICAL SOCIETY TRANSACTIONS (2002)
Human intervertebral disc aggrecan inhibits nerve growth in vitro
WEB Johnson et al.
ARTHRITIS AND RHEUMATISM (2002)
Nerve growth factor expression and innervation of the painful intervertebral disc
AJ Freemont et al.
JOURNAL OF PATHOLOGY (2002)
Matrix protein gene expression in intervertebral disc cells subjected to altered osmolarity
J Chen et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2002)
Candidate-gene approaches for studying complex genetic traits: practical considerations
HK Tabor et al.
NATURE REVIEWS GENETICS (2002)
Intervertebral disc degeneration adjacent to a lumbar fusion - An experimental rabbit model
FM Phillips et al.
JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME (2002)
2001 Volvo Award winner in basic science studies: Effect of nutrient supply on the viability of cells from the nucleus pulposus of the intervertebral disc
HA Horner et al.
SPINE (2001)
Association between sciatica and Propionibacterium acnes
A Stirling et al.
LANCET (2001)
The association of degeneration of the intervertebral disc with 5a/6a polymorphism in the promoter of the human matrix metalloproteinase-3 gene
M Takahashi et al.
JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME (2001)
Identification of a novel common genetic risk factor for lumbar disk disease
P Paassilta et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2001)
Cartilage proteoglycans
CB Knudson et al.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2001)
Nitric oxide mediates the change of proteoglycan synthesis in the human lumbar intervertebral disc in response to hydrostatic pressure
GZ Liu et al.
SPINE (2001)
IL-1 beta sensitizes intervertebral disc annulus cells to fluid-induced shear stress
MK Elfervig et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2001)
Height of lumbar discs measured from radiographs compared with degeneration and height classified from MR images
W Frobin et al.
EUROPEAN RADIOLOGY (2001)
COL9A2 allelotypes in intervertebral disc disease
C Wrocklage et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2000)
Systematic review of psychosocial factors at work and private life as risk factors for back pain
WE Hoogendoorn et al.
SPINE (2000)
Mechanical initiation of intervertebral disc degeneration
MA Adams et al.
SPINE (2000)
The vertebral end-plate: what do we know?
RJ Moore
EUROPEAN SPINE JOURNAL (2000)