4.7 Review

Diverse Control Mechanisms of the Interleukin-1 Cytokine Family

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Multidisciplinary Sciences

Gasdermin D pores are dynamically regulated by local phosphoinositide circuitry

Ana Beatriz Santa Cruz Garcia et al.

Summary: Gasdermin D forms pores in the plasma membrane that display phosphoinositide-dependent dynamics and can be controlled by living cells, potentially providing a therapeutic target for inflammatory diseases.

NATURE COMMUNICATIONS (2022)

Article Immunology

The persistence of interleukin-6 is regulated by a blood buffer system derived from dendritic cells

Ashraf S. Yousif et al.

Summary: The study identified conventional dendritic cells as a major source of circulating sIL-6R, which regulates IL-6 signaling through a T cell-independent pathway, providing important insights into modulating pro-inflammatory immune reactions.

IMMUNITY (2021)

Article Multidisciplinary Sciences

NINJ1 mediates plasma membrane rupture during lytic cell death

Nobuhiko Kayagaki et al.

Summary: Plasma membrane rupture is a cataclysmic event in lytic cell death, releasing damage-associated molecular patterns to propagate the inflammatory response. NINJ1 protein plays an essential role in inducing PMR, with Ninj1-deficient macrophages showing impaired release of intracellular proteins and distinctive ballooned morphology. This study overturns the long-held belief that cell death-related PMR is a passive event, highlighting the active role of NINJ1 in mediating PMR.

NATURE (2021)

Article Multidisciplinary Sciences

Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction

Kendall J. Condon et al.

Summary: Our study identified a catalog of genes that impact the mTORC1 pathway and clarified the multifaceted ways in which mTORC1 senses mitochondria dysfunction.AMPK and HRI are two of the key kinases that signal mitochondria distress to mTORC1, and their loss renders mTORC1 signaling largely resistant to mitochondria dysfunction induced by various inhibitors.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Review Cell Biology

Cellular metabolism in the defense against microbes

Lena Pernas

Summary: The study discusses the resistance of host cell metabolism against pathogens and highlights how rewiring metabolic processes can enhance cellular defenses and hinder microbial growth.

JOURNAL OF CELL SCIENCE (2021)

Article Cell Biology

Itaconate confers tolerance to late NLRP3 inflammasome activation

Monika Bambouskova et al.

Summary: Itaconate, induced upon TLR stimulation, regulates NLRP3 inflammasome activation and synergizes with iNOS, establishing tolerance to NLRP3 inflammasome in inflammatory macrophages. Mechanistically, itaconate prevents full caspase-1 activation and gasdermin D processing, potentially leading to pyroptotic cell death and tissue damage if not controlled.

CELL REPORTS (2021)

Article Microbiology

Genetic targeting of Card19 is linked to disrupted NINJ1 expression, impaired cell lysis, and increased susceptibility to Yersinia infection

Elisabet Bjanes et al.

Summary: Programmed cell death is crucial for tissue homeostasis and host defense, with pyroptosis being an inflammatory form involving cell lysis and release of cytokines. Genetic targeting of Card19 impacts adjacent gene Ninj1, regulating processes of cell lysis downstream of gasdermin cleavage and influencing susceptibility to bacterial infections.

PLOS PATHOGENS (2021)

Article Immunology

Virus-mediated inactivation of anti-apoptotic Bcl-2 family members promotes Gasdermin-E-dependent pyroptosis in barrier epithelial cells

Megan H. Orzalli et al.

Summary: During viral infection, inhibition of protein synthesis triggers pyroptosis in human keratinocytes, leading to the release of inflammatory cytokines. MCL-1 and BCL-xL act as sensors of translation shutdown, contributing to antiviral defense by inhibiting virus replication.

IMMUNITY (2021)

Article Multidisciplinary Sciences

Gasdermin D pore structure reveals preferential release of mature interleukin-1

Shiyu Xia et al.

Summary: Inflammasomes activate caspase-1 to cleave GSDMD and generate mature cytokines like IL-1 beta and IL-18, which are released through pores formed by GSDMD. The GSDMD pore mediates IL-1 release by electrostatic filtering, favoring the passage of mature cytokines over their precursors.

NATURE (2021)

Article Multidisciplinary Sciences

The ubiquitylation of IL-1β limits its cleavage by caspase-1 and targets it for proteasomal degradation

Swarna L. Vijayaraj et al.

Summary: IL-1β is regulated by ubiquitination to prevent excessive activity, reducing inflammation and potential immunopathological damage.

NATURE COMMUNICATIONS (2021)

Article Cell Biology

Gasdermin D mediates the maturation and release of IL-1α downstream of inflammasomes

Kohsuke Tsuchiya et al.

Summary: This study demonstrates that GSDMD is essential for the rapid maturation of IL-1α by nonparticulate inflammasome activators. Ablation of GSDMD prevents the maturation of IL-1α but not IL-1β. The maturation of IL-1α induced by inflammasomes relies on extracellular calcium and calpains, which are induced in a GSDMD-dependent manner.

CELL REPORTS (2021)

Article Cell Biology

Gasdermin E permits interleukin-1 beta release in distinct sublytic and pyroptotic phases

Bowen Zhou et al.

Summary: Gasdermin E (GSDME) functions as an independent conduit for interleukin-1b (IL-1b) release in cellular inflammasome activation, regardless of its cell death ability. Our study reveals that both NLRP3 and NLRP1 inflammasomes depend on both gasdermins for IL-1b processing and release, apart from their ability to induce cell lysis.

CELL REPORTS (2021)

Article Biochemistry & Molecular Biology

Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway

Charles L. Evavold et al.

Summary: The Ragulator-Rag complex is found to be necessary for GSDMD pore formation and pyroptosis in macrophages, promoting GSDMD oligomerization on the plasma membrane. Defects in GSDMD oligomerization and pore formation can be rescued by mitochondrial poisons that stimulate ROS production, and ROS modulation impacts the ability of inflammasome pathways to promote pore formation downstream of GSDMD cleavage.
Article Immunology

Evolution-inspired redesign of the LPS receptor caspase-4 into an interleukin-1β-converting enzyme

Pascal Devant et al.

Summary: Innate immune signaling pathways involve multiple proteins that promote inflammation, with the complexity being a prerequisite for pathway design. Through studying caspases that regulate inflammation, it was found that different caspases can complement each other, condensing a multistep pathway into a single protein.

SCIENCE IMMUNOLOGY (2021)

Review Immunology

Inflammasome signaling and regulation of interleukin-1 family cytokines

Amy H. Chan et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2020)

Article Biochemistry & Molecular Biology

Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis

Kun Wang et al.

Article Cell Biology

Galectin-3 Coordinates a Cellular System for Lysosomal Repair and Removal

Jingyue Jia et al.

DEVELOPMENTAL CELL (2020)

Article Biochemistry & Molecular Biology

A Translocation Pathway for Vesicle-Mediated Unconventional Protein Secretion

Min Zhang et al.

Article Multidisciplinary Sciences

cFLIPL protects macrophages from LPS-induced pyroptosis via inhibition of complex II formation

Hayley I. Muendlein et al.

SCIENCE (2020)

Article Cell Biology

A Two-Cell Model for IL-1β Release Mediated by Death-Receptor Signaling

Carlos A. Donado et al.

CELL REPORTS (2020)

Article Multidisciplinary Sciences

Gasdermin E suppresses tumour growth by activating anti-tumour immunity

Zhibin Zhang et al.

NATURE (2020)

Article Medicine, Research & Experimental

Epithelial-derived gasdermin D mediates nonlytic IL-1β release during experimental colitis

Katarzyna Bulek et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

Article Multidisciplinary Sciences

Succination inactivates gasdermin D and blocks pyroptosis

Fiachra Humphries et al.

SCIENCE (2020)

Article Biochemistry & Molecular Biology

Interleukin-1β Induces mtDNA Release to Activate Innate Immune Signaling via cGAS-STING

Lauren D. Aarreberg et al.

MOLECULAR CELL (2019)

Article Multidisciplinary Sciences

Caspase-1 initiates apoptosis in the absence of gasdermin D

Kohsuke Tsuchiya et al.

NATURE COMMUNICATIONS (2019)

Review Immunology

Inflammasomes: Threat-Assessment Organelles of the Innate Immune System

Charles L. Evavold et al.

IMMUNITY (2019)

Review Immunology

Overview of the IL-1 family in innate inflammation and acquired immunity

Charles A. Dinarello

IMMUNOLOGICAL REVIEWS (2018)

Article Immunology

The Gasdermin-D pore acts as a conduit for IL-1 secretion in mice

Rosalie Heilig et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2018)

Article Immunology

Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity

Dave Boucher et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2018)

Review Biochemistry & Molecular Biology

How Inflammasomes Inform Adaptive Immunity

Charles L. Evavold et al.

JOURNAL OF MOLECULAR BIOLOGY (2018)

Article Biochemistry & Molecular Biology

Galectins Control mTOR in Response to Endomembrane Damage

Jingyue Jia et al.

MOLECULAR CELL (2018)

Article Biochemistry & Molecular Biology

An Antiviral Branch of the IL-1 Signaling Pathway Restricts Immune-Evasive Virus Replication

Megan H. Orzalli et al.

MOLECULAR CELL (2018)

Article Multidisciplinary Sciences

Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection

Joseph Sarhan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Biochemistry & Molecular Biology

Dedicated SNAREs and specialized TRIM cargo receptors mediate secretory autophagy

Tomonori Kimura et al.

EMBO JOURNAL (2017)

Article Multidisciplinary Sciences

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

Yupeng Wang et al.

NATURE (2017)

Article Multidisciplinary Sciences

Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner

Stephanie A. Conos et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Review Cell Biology

Inflammasomes on the Crossroads of Innate Immune Recognition and Metabolic Control

Tomasz Prochnicki et al.

CELL METABOLISM (2017)

Article Biochemistry & Molecular Biology

ESCRT-III Acts Downstream of MLKL to Regulate Necroptotic Cell Death and Its Consequences

Yi-Nan Gong et al.

Article Biochemistry & Molecular Biology

Hexokinase Is an Innate Immune Receptor for the Detection of Bacterial Peptidoglycan

Andrea J. Wolf et al.

Article Biochemistry & Molecular Biology

Inflammasome-dependent IL-1β release depends upon membrane permeabilisation

F. Martin-Sanchez et al.

CELL DEATH AND DIFFERENTIATION (2016)

Article Biochemistry & Molecular Biology

Cell death is not essential for caspase-1-mediated interleukin-1β activation and secretion

S. A. Conos et al.

CELL DEATH AND DIFFERENTIATION (2016)

Article Biochemistry & Molecular Biology

GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death

Lorenzo Sborgi et al.

EMBO JOURNAL (2016)

Article Immunology

Human Monocytes Engage an Alternative Inflammasome Pathway

Moritz M. Gaidt et al.

IMMUNITY (2016)

Article Multidisciplinary Sciences

The amino acid sensor GCN2 controls gut inflammation by inhibiting inflammasome activation

Rajesh Ravindran et al.

NATURE (2016)

Article Multidisciplinary Sciences

Pore-forming activity and structural autoinhibition of the gasdermin family

Jingjin Ding et al.

NATURE (2016)

Article Multidisciplinary Sciences

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

Xing Liu et al.

NATURE (2016)

Article Multidisciplinary Sciences

GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes

Robin A. Aglietti et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Biochemistry & Molecular Biology

A Distinct Function of Regulatory T Cells in Tissue Protection

Nicholas Arpaia et al.

Article Biochemistry & Molecular Biology

Epithelial IL-18 Equilibrium Controls Barrier Function in Colitis

Roni Nowarski et al.

Article Immunology

Caspase-11 activates a canonical NLRP3 inflammasome by promoting K+ efflux

Sebastian Ruehl et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2015)

Article Multidisciplinary Sciences

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

Nobuhiko Kayagaki et al.

NATURE (2015)

Article Multidisciplinary Sciences

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

Jianjin Shi et al.

NATURE (2015)

Review Physiology

MEMBRANE REPAIR: MECHANISMS AND PATHOPHYSIOLOGY

Sandra T. Cooper et al.

PHYSIOLOGICAL REVIEWS (2015)

Article Multidisciplinary Sciences

Extracellular forms of IL-37 inhibit innate inflammation in vitro and in vivo but require the IL-1 family decoy receptor IL-1R8

Suzhao Li et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Immunology

Altered subcellular localization of IL-33 leads to non-resolving lethal inflammation

Juliana Bessa et al.

JOURNAL OF AUTOIMMUNITY (2014)

Article Immunology

The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation

Bernardo S. Franklin et al.

NATURE IMMUNOLOGY (2014)

Article Multidisciplinary Sciences

Role of caspase-1 in nuclear translocation of IL-37, release of the cytokine, and IL-37 inhibition of innate immune responses

Ana-Maria Bulau et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Biochemistry & Molecular Biology

AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC

V. Sagulenko et al.

CELL DEATH AND DIFFERENTIATION (2013)

Article Biochemistry & Molecular Biology

Endogenous IL-1α is a chromatin-associated protein in mouse macrophages

Celine Lamacchia et al.

CYTOKINE (2013)

Review Immunology

The Interleukin-1 Family: Back to the Future

Cecilia Garlanda et al.

IMMUNITY (2013)

Review Biochemistry & Molecular Biology

The Tangled Circuitry of Metabolism and Apoptosis

Joshua L. Andersen et al.

MOLECULAR CELL (2013)

Article Multidisciplinary Sciences

IL-38 binds to the IL-36 receptor and has biological effects on immune cells similar to IL-36 receptor antagonist

Frank L. van de Veerdonk et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Multidisciplinary Sciences

IL-33 is processed into mature bioactive forms by neutrophil elastase and cathepsin G

Emma Lefrancais et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Biochemistry & Molecular Biology

Autophagy-based unconventional secretory pathway for extracellular delivery of IL-1β

Nicolas Dupont et al.

EMBO JOURNAL (2011)

Article Biochemistry & Molecular Biology

Granzyme B-Dependent Proteolysis Acts as a Switch to Enhance the Proinflammatory Activity of IL-1α

Inna S. Afonina et al.

MOLECULAR CELL (2011)

Article Multidisciplinary Sciences

TFEB Links Autophagy to Lysosomal Biogenesis

Carmine Settembre et al.

SCIENCE (2011)

Article Biochemistry & Molecular Biology

Inhibition of Toll-like receptors TLR4 and 7 signaling pathways by SIGIRR: A computational approach

Jing Gong et al.

JOURNAL OF STRUCTURAL BIOLOGY (2010)

Article Immunology

IL-37 is a fundamental inhibitor of innate immunity

Marcel F. Nold et al.

NATURE IMMUNOLOGY (2010)

Article Immunology

Caspase-1, Caspase-8, and Calpain Are Dispensable for IL-33 Release by Macrophages

Tatsukuni Ohno et al.

JOURNAL OF IMMUNOLOGY (2009)

Article Multidisciplinary Sciences

The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1

Corinne Cayrol et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Multidisciplinary Sciences

A Gene Network Regulating Lysosomal Biogenesis and Function

Marco Sardiello et al.

SCIENCE (2009)

Article Biochemistry & Molecular Biology

Active caspase-1 is a regulator of unconventional protein secretion

Martin Keller et al.

Article Multidisciplinary Sciences

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

Tatsuya Saitoh et al.

NATURE (2008)

Article Multidisciplinary Sciences

IL-1 receptor accessory protein is essential for IL-33-induced activation of T lymphocytes and mast cells

Shafaqat Ali et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Immunology

Opposing activities of two novel members of the IL-1 ligand family regulate skin inflammation

Hal Blumberg et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2007)

Article Immunology

IL-1 receptor accessory protein and ST2 comprise the IL-33 receptor complex

Alissa A. Chackerian et al.

JOURNAL OF IMMUNOLOGY (2007)

Article Multidisciplinary Sciences

IL-33, the IL-1-like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factor in vivo

Virginie Carriere et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Multidisciplinary Sciences

The precursor form of IL-1α is an intracrine proinflammatory activator of transcription

A Werman et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Immunology

Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide

I Caramalho et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2003)

Article Multidisciplinary Sciences

The promoter of IL-18 binding protein:: Activation by an IFN-γ-induced complex of IFN regulatory factor 1 and CCAAT/enhancer binding protein β

V Hurgin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Article Physiology

Effect of interleukin-18 on mouse core body temperature

S Gatti et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2002)

Article Multidisciplinary Sciences

Structural requirements of six naturally occurring isoforms of the IL-18 binding protein to inhibit IL-18

SH Kim et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)

Article Biochemistry & Molecular Biology

Interferon-γ mediates gene expression of IL-18 binding protein in nonleukocytic cells

H Mühl et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2000)