4.7 Article

Protein Kinase CK2 represents a new target to boost Ibrutinib and Venetoclax induced cytotoxicity in mantle cell lymphoma

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Oncology

CSNK2 in cancer: pathophysiology and translational applications

Scott W. Strum et al.

Summary: CSNK2 is frequently dysregulated in cancer, influencing apoptosis evasion, proliferation, cell invasion/metastasis, and cell cycle control. It holds prognostic significance in various cancers, and inhibition in xenograft experiments shows positive treatment response.

BRITISH JOURNAL OF CANCER (2022)

Article Oncology

Regulation of B-Cell Receptor Signaling and Its Therapeutic Relevance in Aggressive B-Cell Lymphomas

Nuria Profitos-Peleja et al.

Summary: Dysregulated BCR signaling is a crucial factor in the survival of B-NHL tumors, and BCR-targeted therapies provide alternative treatment options. However, durable responses to these drugs are often not achieved. This review discusses the role of BCR signaling in B-NHLs, the mechanisms of BCR-targeted therapies, and the development of new treatment strategies.

CANCERS (2022)

Article Hematology

Mantle cell lymphoma in 2022-A comprehensive update on molecular pathogenesis, risk stratification, clinical approach, and current and novel treatments

Preetesh Jain et al.

Summary: The field of mantle cell lymphoma (MCL) has made remarkable progress in molecular pathogenesis, prognostication, and newer treatments. MCL consists of various clinical subtypes and has complex pathogenesis. Treatment options range from conventional chemotherapy to targeted therapy and cellular therapy.

AMERICAN JOURNAL OF HEMATOLOGY (2022)

Review Biochemistry & Molecular Biology

Targeting Protein Kinases in Blood Cancer: Focusing on CK1α and CK2

Zaira Spinello et al.

Summary: Disruption of protein kinase activity can lead to cancer development and progression, with CK1α and CK2 playing key roles in blood-origin tumors. Mutations in the genes encoding these kinases are rare, and they are not within the paradigm of oncogene dependency, presenting potential therapeutic targets in cancer treatment.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Oncology

Protein Kinase CK1α Sustains B-Cell Receptor Signaling in Mantle Cell Lymphoma

Sabrina Manni et al.

Summary: Mantle Cell Lymphoma (MCL) is an incurable B-cell malignancy with poor prognosis. Protein kinase CK1 alpha plays a crucial role in sustaining MCL growth by regulating BCR-related survival signaling cascades. Inhibition of CK1 alpha combined with Ibrutinib or Duvelisib can synergistically increase cytotoxicity and decrease BCR signaling activation in MCL cells.

FRONTIERS IN ONCOLOGY (2021)

Review Pharmacology & Pharmacy

Targeting BCL2 in Chronic Lymphocytic Leukemia and Other Hematologic Malignancies

Fevzi F. Yalniz et al.

Review Hematology

Ibrutinib resistance in mantle cell lymphoma: clinical, molecular and treatment aspects

Oshrat Hershkovitz-Rokah et al.

BRITISH JOURNAL OF HAEMATOLOGY (2018)

Review Oncology

NF-κB signaling and its relevance to the treatment of mantle cell lymphoma

Swathi Balaji et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2018)

Article Medicine, General & Internal

Ibrutinib plus Venetoclax for the Treatment of Mantle-Cell Lymphoma

Constantine S. Tam et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Review Cell Biology

Multifaceted Roles of GSK-3 in Cancer and Autophagy-Related Diseases

Romina Mancinelli et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2017)

Article Multidisciplinary Sciences

Unification of de novo and acquired ibrutinib resistance in mantle cell lymphoma

Xiaohong Zhao et al.

NATURE COMMUNICATIONS (2017)

Review Biochemistry & Molecular Biology

Targeting CK2-driven non-oncogene addiction in B-cell tumors

E. Mandato et al.

ONCOGENE (2016)

Review Oncology

ABT-199 (venetoclax) and BCL-2 inhibitors in clinical development

Shundong Cang et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2015)

Article Cell Biology

On CK2 regulation of chronic lymphocytic leukemia cell viability

Leila R. Martins et al.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2011)

Article Biochemistry & Molecular Biology

A Peptide-Based Target Screen Implicates the Protein Kinase CK2 in the Global Regulation of Caspase Signaling

James S. Duncan et al.

SCIENCE SIGNALING (2011)

Article Cell Biology

Activity of protein kinase CK2 uncouples Bid cleavage from caspase-8 activation

Christian T. Hellwig et al.

JOURNAL OF CELL SCIENCE (2010)

Article Biochemistry & Molecular Biology

Dephosphorylation and inactivation of Akt/PKB is counteracted by protein kinase CK2 in HEK 293T cells

Giovanni Di Maira et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2009)

Article Multidisciplinary Sciences

mTORC1 promotes survival through translational control of Mcl-1

John R. Mills et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Biochemistry & Molecular Biology

mir-29 regulates Mcl-1 protein expression and apoptosis

J. L. Mott et al.

ONCOGENE (2007)

Article Biochemistry & Molecular Biology

Translational repression of MCL-1 couples stress-induced eIF2α phosphorylation to mitochondrial apoptosis initiation

Ralph M. Fritsch et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Biochemistry & Molecular Biology

Phosphorylation of bid by casein kinases I and II regulates its cleavage by caspase 8

S Desagher et al.

MOLECULAR CELL (2001)

Article Biochemistry & Molecular Biology

Tumor necrosis factor α-induced phosphorylation of RelA/p65 on Ser529 is controlled by casein kinase II

D Wang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)