4.7 Article

Remote ischemic preconditioning causes transient cell cycle arrest and renal protection by a NF-κB-dependent Sema5B pathway

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JCI INSIGHT
卷 7, 期 14, 页码 -

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AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/jci.insight.158523

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  1. Center for Interdisciplinary Clinical Research (IZKF Munster) [Ross2/010/18]
  2. Deutsche Forschungsgemeinschaft [RO4537/4-1, ME 5413/1-1, PA 483/17-1, ZA428/17-1, SFB1009A05]

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Remote ischemic preconditioning (RIPC) provides renal protection by modulating HMGB1 levels. In mice, RIPC reduces renal ischemia-reperfusion injury and improves kidney function. This protection is mediated by activation of AMPKa and NF-.B, which leads to the upregulation of Sema5b.
Acute kidney injury increases morbidity and mortality, and previous studies have shown that remote ischemic preconditioning (RIPC) reduces the risk of acute kidney injury after cardiac surgery. RIPC increases urinary high mobility group box protein-1 (HMGB1) levels in patients, and this correlates with kidney protection. Here, we show that RIPC reduces renal ischemiareperfusion injury and improves kidney function in mice. Mechanistically, RIPC increases HMGB1 levels in the plasma and urine, and HMGB1 binds to TLR4 on renal tubular epithelial cells, inducing transcriptomic modulation of renal tubular epithelial cells and providing renal protection, whereas TLR4 activation on nonrenal cells was shown to contribute to renal injury. This protection is mediated by activation of induction of AMPKa and NF-.B; this induction contributes to the upregulation of Sema5b, which triggers a transient, protective G 1 cell cycle arrest. In cardiac surgery patients at high risk for postoperative acute kidney injury, increased HMGB1 and Sema5b levels after RIPC were associated with renal protection after surgery. The results may help to develop future clinical treatment options for acute kidney injury.

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