HINGEneering IgG for enhanced immune activation

Two recent studies in Science Immunology by Orr et al. and Foss et al. demonstrate that the hinge region of immunoglobulin G (IgG) is a major regulator of IgG2 and IgG3 activity, respectively. Engineering of the IgG hinge may therefore be useful for optimizing the activity of IgG subclasses.

Automated summary

Two recent studies in Science Immunology demonstrate that the hinge region of immunoglobulin G (IgG) is a major regulator of IgG2 and IgG3 activity. Engineering of the IgG hinge may be useful for optimizing the activity of IgG subclasses.