CXCL9 and CXCL10 bring the heat to tumors

CXCL9 and CXCL10 can be produced by antigen-presenting cells (dendritic cells or macrophages) and by tumor cells. Hoch et al. demonstrated that CXCL9 and CXCL10 co-localize with LAG3(+) T cells expressing CCL4 or CXCL13 and contribute to the generation of a hot tumor microenvironment.

Automated summary

CXCL9 and CXCL10 are produced by antigen-presenting cells and tumor cells, and they co-localize with LAG3(+) T cells expressing CCL4 or CXCL13, contributing to the generation of a hot tumor microenvironment.