Antibacterial and anticancer potential of mycosynthesized titanium dioxide (TiO2) nanoparticles using Hypsizygus ulmarius

The present study was to examine the antibacterial and anticancer potential of titanium dioxide mediated (TiO2) nanoparticles using Hypsizygus ulmarius. The nanoparticles were characterized using UV, XRD, FTIR, SEM, EDX, HR-TEM, PSA, and zeta potential. The UV-visible spectroscopy results exhibited a sharp absorbance peak range at 264 nm. The X-ray diffraction analysis reflected the presence of diffraction major peak range at (101), (103), (004), (200), (112), (200), (105), (211), (213), (314), (602), and (215) planes of face centered cubic TiO(2)NPs. The HR-TEM absorption was expressed the presence of spherical structure particles with a normal size of 80 nm. The EDX results of mycosynthesized TiO(2)NPs recorded the strong major intense signal which confirms the presence of pure Ti (85%). Mycosynthesized TiO(2)NPs have a zeta potential value of - 18.4 mV, it shows that they are stable in water. For antibacterial assay, the mycosynthesized TiO(2)NPs have broad spectrum of growth inhibition against tested human pathogenic bacteria viz., S. aureus (8.4 +/- 0.3), B. cereus (7.1 +/- 0.5), E. coli (6.2 +/- 0.3), and K. pneumoniae (4.0 +/- 0.1 mm). The anticancer activity results of green synthesized TiO(2)NPs proved as highly toxic for the HepG(2) cell line and show a reduced cell viability (85%) and L-50 value of 83.3 mu g/ml after 24 h treatment. Finally, outcome of the present investigation shows that the mycosynthesized titanium dioxide nanoparticles using mushroom extract served as an alternative and eco-friendly nano drugs in the near future.

Automated summary

The present study synthesized titanium dioxide nanoparticles using Hypsizygus ulmarius and examined their antibacterial and anticancer potential. The nanoparticles showed stable properties and broad-spectrum antibacterial activity, as well as high toxicity against HepG(2) cell line.