4.5 Review

Therapeutic application of carvacrol: A comprehensive review

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Review Veterinary Sciences

Thymol and carvacrol supplementation in poultry health and performance

Majid Gholami-Ahangaran et al.

Summary: This study discusses the role of thymol and carvacrol in poultry production, showing that these natural compounds have a wide range of biological activities, including promoting growth, improving feed utilization, and protecting the liver in chickens. Additionally, they can impact egg composition, quality, and chicken behavior.

VETERINARY MEDICINE AND SCIENCE (2022)

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Effects of Carvacrol in an Experimentally Induced Esophageal Burn Model: Expression of VEGF and Caspase-3 Proteins

Hikmet Zeytun et al.

Summary: The study demonstrated that carvacrol could enhance mitotic activity of basal cells in the epithelial layer, alleviate cell necrosis and inflammation, and offer protective effects on esophageal tissue structure in an experimental esophageal burn rat model.

JOURNAL OF INVESTIGATIVE SURGERY (2021)

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Safety and tolerability of carvacrol in healthy subjects: a phase I clinical study

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Summary: The study assessed the safety and tolerability of carvacrol in healthy individuals. Some biochemical parameters showed changes during treatment, but remained within normal range, indicating overall clinical safety and tolerability for this agent.

DRUG AND CHEMICAL TOXICOLOGY (2021)

Review Chemistry, Applied

A review on colloidal delivery vehicles using carvacrol as a model bioactive compound

Pu Wang et al.

Summary: Bioactive compounds face challenges in being applied in various industries, with colloidal delivery systems showing potential as a suitable approach to overcome solubility and stability issues.

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Carvacrol suppresses learning and memory dysfunction and hippocampal damages caused by chronic cerebral hypoperfusion

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NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2020)

Article Pharmacology & Pharmacy

Effects of the solid lipid nanoparticle of carvacrol on rodents with lung injury from smoke inhalation

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NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2020)

Review Biotechnology & Applied Microbiology

Poly(lactic acid)/carvacrol-based materials: preparation, physicochemical properties, and antimicrobial activity

Roberto Scaffaro et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2020)

Article Medicine, Research & Experimental

Potential anti-inflammatory and immunomodulatory effects of carvacrol against ovalbumin-induced asthma in rats

Yousra M. Ezz-Eldin et al.

LIFE SCIENCES (2020)

Article Gastroenterology & Hepatology

Carvacrol ameliorates acute campylobacteriosis in a clinical murine infection model

Soraya Mousavi et al.

GUT PATHOGENS (2020)

Article Medicine, Research & Experimental

Carvacrol protects against diabetes-induced hypercontractility in the aorta through activation of the PI3K/Akt pathway

Yun Liu et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

Article Pharmacology & Pharmacy

Inhibitory effect of carvacrol on lipopolysaccharide-induced memory impairment in rats

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KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY (2020)

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Effects of thymol and carvacrol on sperm quality and oxidant/antioxidant balance in rats

Mehmet Guvenc et al.

ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY (2019)

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The ameliorative effect of carvacrol on oxidative stress and germ cell apoptosis in testicular tissue of adult diabetic rats

Hamed Shoorei et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

Article Food Science & Technology

Carvacrol/β-cyclodextrin inclusion complex inhibits cell proliferation and migration of prostate cancer cells

Gabriela G. G. Trindade et al.

FOOD AND CHEMICAL TOXICOLOGY (2019)

Article Food Science & Technology

Combined effects of thymol, carvacrol and packaging on the shelf-life of marinated chicken

Layal Karam et al.

INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY (2019)

Article Pharmacology & Pharmacy

Inhibition of salt appetite in sodium-depleted rats by carvacrol: Involvement of noradrenergic and serotonergic pathways

Filip de Souza Palli et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2019)

Article Biochemistry & Molecular Biology

Oral administration of carvacrol/β-cyclodextrin complex protects against 6-hydroxydopamine-induced dopaminergic denervation

Camila Tiefensee Ribeiro et al.

NEUROCHEMISTRY INTERNATIONAL (2019)

Article Food Science & Technology

Carvacrol loaded halloysite coatings for antimicrobial food packaging applications

Buket Alkan Tas et al.

FOOD PACKAGING AND SHELF LIFE (2019)

Article Food Science & Technology

Carvacrol inhibits cytochrome P450 and protects against binge alcohol-induced liver toxicity

Imran Khan et al.

FOOD AND CHEMICAL TOXICOLOGY (2019)

Article Pharmacology & Pharmacy

Carvacrol Attenuates Diabetic Cardiomyopathy by Modulating the PI3K/AKT/GLUT4 Pathway in Diabetic Mice

Ning Hou et al.

FRONTIERS IN PHARMACOLOGY (2019)

Article Chemistry, Medicinal

Heterocyclic β-keto sulfide derivatives of carvacrol: Synthesis and copper (II) ion reducing capacity

Alexander H. Cocolas et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2019)

Article Immunology

Design, synthesis and pharmacological evaluation of CVIB, a codrug of carvacrol and ibuprofen as a novel anti-inflammatory agent

Michelle de Oliveira Pedrosa Rolim et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2019)

Article Biochemistry & Molecular Biology

Development of antimicrobial and antioxidant electrospun soluble potato starch nanofibers loaded with carvacrol

Laura Martins Fonseca et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

Article Food Science & Technology

Use of allyl-isothiocyanate and carvacrol to preserve fresh chicken meat during chilling storage

Khabat Noori Hussein et al.

CZECH JOURNAL OF FOOD SCIENCES (2019)

Article Biochemistry & Molecular Biology

Carvacrol suppresses inflammatory responses in rheumatoid arthritis fibroblast-like synoviocytes

Yu Li et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2019)

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Carvacrol inhibits cadmium toxicity through combating against caspase dependent/independent apoptosis in PC12 cells

Subrata Banik et al.

FOOD AND CHEMICAL TOXICOLOGY (2019)

Article Medicine, General & Internal

Antiproliferative and Anti-invasion Effects of Carvacrol on PC3 Human Prostate Cancer Cells through Reducing pSTAT3, pAKT, and pERK1/2 Signaling Proteins

Esfandiar Heidarian et al.

INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE (2019)

Article Toxicology

Benzo(a)pyrene induces lung toxicity and inflammation in mice: prevention by carvacrol

P. Barnwal et al.

HUMAN & EXPERIMENTAL TOXICOLOGY (2018)

Article Food Science & Technology

Antimicrobial Carvacrol in Solution Blow-Spun Fish-Skin Gelatin Nanofibers

Fei Liu et al.

JOURNAL OF FOOD SCIENCE (2018)

Review Chemistry, Medicinal

Carvacrol and human health: A comprehensive review

Mehdi Sharifi-Rad et al.

PHYTOTHERAPY RESEARCH (2018)

Article Multidisciplinary Sciences

Carvacrol reduces adipogenic differentiation by modulating autophagy and ChREBP expression

Sonia Spalletta et al.

PLOS ONE (2018)

Review Endocrinology & Metabolism

Diabetic cardiomyopathy: a hyperglycaemia- and insulin-resistance-induced heart disease

Guanghong Jia et al.

DIABETOLOGIA (2018)

Review Biochemistry & Molecular Biology

Analgesic-Like Activity of Essential Oil Constituents: An Update

Rita de Cassia da Silveira e Sa et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Article Microbiology

Carvacrol and thymol: strong antimicrobial agents against resistant isolates

Mohammad Y. Memar et al.

REVIEWS IN MEDICAL MICROBIOLOGY (2017)

Review Food Science & Technology

Oregano Essential Oil as an Antimicrobial and Antioxidant Additive in Food Products

I. Rodriguez-Garcia et al.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2016)

Article Biotechnology & Applied Microbiology

The carvacrol ameliorates acute pancreatitis-induced liver injury via antioxidant response

Murat Bakir et al.

CYTOTECHNOLOGY (2016)

Article Biochemistry & Molecular Biology

Thymol and Carvacrol Prevent Doxorubicin-Induced Cardiotoxicity by Abrogation of Oxidative Stress, Inflammation, and Apoptosis in Rats

El-Sayed M. El-Sayed et al.

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2016)

Article Biochemistry & Molecular Biology

Carvacrol reduces irinotecan-induced intestinal mucositis through inhibition of inflammation and oxidative damage via TRPA1 receptor activation

Elenice M. Alvarenga et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2016)

Article Food Science & Technology

Carvacrol attenuates acute kidney injury induced by cisplatin through suppression of ERK and PI3K/Akt activation

Iva Potocnjak et al.

FOOD AND CHEMICAL TOXICOLOGY (2016)

Article Food Science & Technology

Genotoxicity evaluation of carvacrol in rats using a combined micronucleus and comet assay

Maria Llana-Ruiz-Cabello et al.

FOOD AND CHEMICAL TOXICOLOGY (2016)

Article Biochemistry & Molecular Biology

Ameliorative Effect of Carvacrol on Cisplatin-Induced Reproductive Damage in Male Rats

Emrah Hicazi Aksu et al.

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2016)

Article Biochemical Research Methods

Protective Effects of Carvacrol against Oxidative Stress Induced by Chronic Stress in Rat's Brain, Liver, and Kidney

Saeed Samarghandian et al.

BIOCHEMISTRY RESEARCH INTERNATIONAL (2016)

Article Veterinary Sciences

THE EFFECT OF CARVACROL ON INFLAMMATORY PAIN AND MOTOR COORDINATION IN RATS

Mirjana Milovanovic et al.

ACTA VETERINARIA-BEOGRAD (2016)

Article Pharmacology & Pharmacy

Participation of the TRP channel in the cardiovascular effects induced by carvacrol in normotensive rat

Bruna Priscilla Vasconcelos Dantas et al.

VASCULAR PHARMACOLOGY (2015)

Review Food Science & Technology

The Bioactivity and Toxicological Actions of Carvacrol

Zacharias E. Suntres et al.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2015)

Article Pharmacology & Pharmacy

Modulation of Cytokine Production and Transcription Factors Activities in Human Jurkat T Cells by Thymol and Carvacrol

Nasser Gholijani et al.

ADVANCED PHARMACEUTICAL BULLETIN (2015)

Article Integrative & Complementary Medicine

CARVACROL AMELIORATES THE PPAR-A AND CYTOCHROME P450 EXPRESSION ON D-GALACTOSAMINE INDUCED HEPATOTOXICITY RATS

Balakrishnan Aristatile et al.

AFRICAN JOURNAL OF TRADITIONAL COMPLEMENTARY AND ALTERNATIVE MEDICINES (2014)

Article Biochemistry & Molecular Biology

Modulation of Pb(II) Caused Aortal Constriction by Eugenol and Carvacrol

Hiba Shabir et al.

BIOLOGICAL TRACE ELEMENT RESEARCH (2014)

Article Biotechnology & Applied Microbiology

Carvacrol partially reverses symptoms of diabetes in STZ-induced diabetic rats

Gokhan Bayramoglu et al.

CYTOTECHNOLOGY (2014)

Article Biotechnology & Applied Microbiology

Antiviral efficacy and mechanisms of action of oregano essential oil and its primary component carvacrol against murine norovirus

D. H. Gilling et al.

JOURNAL OF APPLIED MICROBIOLOGY (2014)

Article Pharmacology & Pharmacy

Carvacrol Protects against Acute Myocardial Infarction of Rats via Anti-oxidative and Anti-apoptotic Pathways

Wei Yu et al.

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2013)

Article Biochemistry & Molecular Biology

Carvacrol Attenuates Diabetes-Associated Cognitive Deficits in Rats

Wenjing Deng et al.

JOURNAL OF MOLECULAR NEUROSCIENCE (2013)

Article Biochemistry & Molecular Biology

Carvacrol: From Ancient Flavoring to Neuromodulatory Agent

Margherita Zotti et al.

MOLECULES (2013)

Article Biotechnology & Applied Microbiology

Anti-proliferative and pro-apoptotic effect of carvacrol on human hepatocellular carcinoma cell line HepG-2

Qing-hua Yin et al.

CYTOTECHNOLOGY (2012)

Article Chemistry, Medicinal

Anti-Inflammatory and Anti-Ulcer Activities of Carvacrol, a Monoterpene Present in the Essential Oil of Oregano

Francilene V. Silva et al.

JOURNAL OF MEDICINAL FOOD (2012)

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Gastroprotective activity of carvacrol on experimentally induced gastric lesions in rodents

Irisdalva S. Oliveira et al.

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2012)

Article Food Science & Technology

The antimicrobial activity of microencapsulated thymol and carvacrol

Abel Guarda et al.

INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY (2011)

Article Biochemistry & Molecular Biology

Potential Antibacterial Activity of Carvacrol-Loaded Poly(DL-lactide-co-glycolide) (PLGA) Nanoparticles against Microbial Biofilm

Antonio Iannitelli et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2011)

Article Pharmacology & Pharmacy

Vasorelaxant effects of the monoterpenic phenol isomers, carvacrol and thymol, on rat isolated aorta

D. Peixoto-Neves et al.

FUNDAMENTAL & CLINICAL PHARMACOLOGY (2010)

Article Biochemistry & Molecular Biology

Carvacrol, a component of thyme oil, activates PPAR alpha and gamma and suppresses COX-2 expression

Mariko Hotta et al.

JOURNAL OF LIPID RESEARCH (2010)