Fibroblast growth factor 21 and bone homeostasis

Fibroblast growth factor 21 (FGF21), a member of the FGF subfamily, is produced primarily in the liver and adipose tissue. The main function of FGF21 is to regulate energy meta-bolism of carbohydrates and lipids in the body through endocrine and other means, making FGF21 have potential clinical value in the treatment of metabolic disorders. Although FGF21 and its receptors play a role in the regulation of bone homeostasis through a variety of signaling pathways, a large number of studies have reported that the abuse of FGF21 and its analogues and the abnormal expression of FGF21 in vivo may be associated with bone abnormalities. Due to limited research information on the effect of FGF21 on bone metabolism regulation, the role of FGF21 in the process of bone homeostasis regu-lation and the mechanism of its occurrence and development have not been fully clarified. Certainly, the various roles played by FGF21 in the regulation of bone homeostasis deserve increasing attention. In this review, we summarize the basic physiological knowledge of FGF21 and the effects of FGF21 on metabolic homeostasis of the skeletal system in animal and human studies. The information provided in this review may prove beneficial for the intervention of bone diseases.

Automated summary

FGF21 is primarily produced in the liver and adipose tissue and plays a crucial role in regulating energy metabolism of carbohydrates and lipids in the body. It has potential clinical value in treating metabolic disorders. However, the abuse and abnormal expression of FGF21 may be associated with bone abnormalities. The role of FGF21 in bone metabolism regulation and its mechanism are still not fully understood, but worthy of increasing attention.