☆ 4.4 Review

Pembrolizumab-induced Stevens-Johnson syndrome in advanced squamous cell carcinoma of the lung: A case report and review of literature

WORLD JOURNAL OF CLINICAL CASES (2022)

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Article Ophthalmology

Pembrolizumab-induced Stevens-Johnson Syndrome with Severe Ocular Complications

Soyoung Ryu et al.

Summary: This case report highlights a unique case of Stevens-Johnson syndrome with severe ocular complications induced by pembrolizumab, an immune checkpoint inhibitor. The patient's symptoms improved after cessation of pembrolizumab treatment and administration of steroids systemically. Immune checkpoint inhibitors have been widely used in cancer treatment, but may lead to adverse events, such as SJS with severe ocular complications.

OCULAR IMMUNOLOGY AND INFLAMMATION (2022)

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Letter Allergy

Early high-dose intravenous corticosteroids rapidly arrest Stevens Johnson syndrome and drug reaction with eosinophilia and systemic symptoms recurrence on drug re-exposure

Rannakoe J. Lehloenya et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2021)

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Review Immunology

The Roles of Immunoregulatory Networks in Severe Drug Hypersensitivity

Yun-Shiuan Olivia Hsu et al.

Summary: The immunomodulatory effects of regulatory T cells and co-signaling receptors are important in balancing immunogenic and immunotolerant responses, which may be disrupted in autoimmune and infectious diseases. Drug hypersensitivity has a wide range of manifestations, from mild to severe, and recent studies suggest that insufficient regulation by Tregs may play a role in severe hypersensitivity reactions.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Oncology

Analysis of immune-mediated reactions in patients with non-small cell lung cancer treated with nivolumab and its association with effectiveness

Susana Cortijo-Cascajares et al.

Summary: This study focused on immune-related adverse events (irAEs) in non-small cell lung cancer (NSCLC) patients treated with nivolumab. The results showed that patients who developed irAEs had longer progression free survival (PFS) and overall survival (OS) compared to those without irAEs, with statistically significant differences. Furthermore, patients who experienced two or more irAEs derived the greatest benefit in terms of treatment effectiveness.

JOURNAL OF ONCOLOGY PHARMACY PRACTICE (2021)

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Article Medicine, General & Internal

Clinical Aspects of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis With Severe Ocular Complications in Taiwan

David Hui-Kang Ma et al.

Summary: Recent advancements in the treatment of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) have shown progress in improving ophthalmic outcomes. A study of 119 patients at Chang Gung Memorial Hospital Linkou Branch from 2010 to 2020 revealed a high incidence of severe ocular complications (SOCs) in the acute stage, with antiepileptic drugs being a common cause. Furthermore, early treatment with etanercept and amniotic membrane transplantation (AMT) showed promising outcomes in reducing chronic ocular sequelae in SJS/TEN patients.

FRONTIERS IN MEDICINE (2021)

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Article Oncology

Pembrolizumab plus pemetrexed-platinum for metastatic nonsquamous non-small-cell lung cancer: KEYNOTE-189 Japan Study

Hidehito Horinouchi et al.

Summary: In the global and Japan extension studies of KEYNOTE-189, pembrolizumab plus pemetrexed-platinum significantly improved overall survival and progression-free survival in Japanese patients with previously untreated metastatic nonsquamous non-small-cell lung cancer, with manageable safety.

CANCER SCIENCE (2021)

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Article Dermatology

Pembrolizumab-Induced Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis in a Patient With Metastatic Cervical Squamous Cell Carcinoma: A Case Report

Shamika Robinson et al.

AMERICAN JOURNAL OF DERMATOPATHOLOGY (2020)

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Review Oncology

Combination Therapy of Ipilimumab and Nivolumab-associated Toxic Epidermal Necrolysis (TEN) in a Patient With Metastatic Melanoma: A Case Report and Literature Review

Ian T. Logan et al.

JOURNAL OF IMMUNOTHERAPY (2020)

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Review Dermatology

Stevens-Johnson syndrome and toxic epidermal necrolysis-like reactions to checkpoint inhibitors: a systematic review

Nolan J. Maloney et al.

INTERNATIONAL JOURNAL OF DERMATOLOGY (2020)

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Review Dermatology

Toxic Epidermal Necrolysis and Steven-Johnson Syndrome: A Comprehensive Review

Olivia A. Charlton et al.

ADVANCES IN WOUND CARE (2020)

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Article Oncology

Management of immune checkpoint inhibitor-related dermatologic adverse events

Xiaoyan Si et al.

THORACIC CANCER (2020)

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Article Oncology

Multisystem Immune-Related Adverse Events Associated With Immune Checkpoint Inhibitors for Treatment of Non-Small Cell Lung Cancer

Bairavi Shankar et al.

JAMA ONCOLOGY (2020)

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Article Medicine, General & Internal

Stevens Johnson Syndrome in a Patient with Giant Cell Arteritis During Short Term Tocilizumab Therapy

Niranjani Venkateswaran et al.

CUREUS JOURNAL OF MEDICAL SCIENCE (2020)

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Article Medicine, General & Internal

Stevens-Johnson Syndrome-Like Reaction After Exposure to Pembrolizumab and Recombinant Zoster Vaccine in a Patient With Metastatic Lung Cancer

Ivy Riano et al.

JOURNAL OF INVESTIGATIVE MEDICINE HIGH IMPACT CASE REPORTS (2020)

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Article Medicine, General & Internal

Therapeutic Effects of Mesenchymal Stem Cells on a Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Model

So-Young Park et al.

JOURNAL OF KOREAN MEDICAL SCIENCE (2020)

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Review Dermatology

Efficacy and safety of cyclosporine in Stevens-Johnson syndrome and toxic epidermal necrolysis

Morgan Gilbert et al.

DERMATOLOGIC THERAPY (2019)

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Review Allergy

Principles of prophylactic and therapeutic management of skin toxicity during treatment with checkpoint inhibitors

Grazyna Kaminska-Winciorek et al.

POSTEPY DERMATOLOGII I ALERGOLOGII (2019)

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Article Dermatology

Severe Cutaneous Adverse Reactions: A Single-Center Retrospective Study of 173 Patients in China

Zhongyi Xu et al.

ANNALS OF DERMATOLOGY (2019)

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Editorial Material Oncology

Stevens-Johnson Syndrome Induced by Pembrolizumab in a Lung Cancer Patient

Naoki Haratake et al.

JOURNAL OF THORACIC ONCOLOGY (2018)

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Letter Rheumatology

High proportion of drug hypersensitivity reactions to sulfasalazine following its use in anti-PD-1-associated inflammatory arthritis

Mark Ford et al.

RHEUMATOLOGY (2018)

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Article Dermatology

Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis: A Multicenter Retrospective Study of 377 Adult Patients from the United States

Robert G. Micheletti et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2018)

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Letter Oncology

Stevens-Johnson syndrome during nivolumab treatment of NSCLC

M. Salati et al.

ANNALS OF ONCOLOGY (2018)

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Article Oncology

Pembrolizumab-induced Stevens-Johnson syndrome in non-melanoma patients

Stephanie Saw et al.

EUROPEAN JOURNAL OF CANCER (2017)

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Article Dermatology

Epidermal programmed cell death-ligand 1 expression in TEN associated with nivolumab therapy

Karina L. Vivar et al.

JOURNAL OF CUTANEOUS PATHOLOGY (2017)

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Article Dermatology

Cyclosporine Use in Epidermal Necrolysis Is Associated with an Important Mortality Reduction: Evidence from Three Different Approaches

Carlos Gonzalez-Herrada et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2017)

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Article Medicine, General & Internal

Pembrolizumab for the Treatment of Non-Small-Cell Lung Cancer

Edward B. Garon et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

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