Suitability Classification of Retinal Fundus Images for Diabetic Retinopathy Using Deep Learning

Diabetic retinopathy (DR) is the primary cause of blindness in developing and developed countries. Early-stage DR detection reduces the risk of blindness in Diabetes Mellitus (DM) patients. There has been a sharp rise in the prevalence of DM in recent years, especially in low- and middle-income countries. In this context, automated artificial intelligence-based DM screening is a crucial tool to help classify the considerable amount of Retinal Fundus Images (RFI). However, retinal image quality assessment has shown to be fundamental in real-world DR screening processes to avoid out-of-distribution data, drift, and images lacking relevant anatomical information. This work analyzes the spatial domain features and image quality assessment metrics for carrying out Deep Learning (DL) classification and detecting notable features in RFI. In addition, a novel lightweight convolutional neural network is proposed specifically for binary classification at a low computational cost. The training results are comparable to state-of-the-art neural networks, which are widely used in DL applications. The implemented architecture achieves 98.6% area under the curve, and 97.66%, and 98.33% sensitivity and specificity, respectively. Moreover, the object detection model trained achieves 94.5% mean average precision. Furthermore, the proposed approach can be integrated into any automated RFI analysis system.

Automated summary

Diabetic retinopathy is a major cause of blindness, and automated diabetes screening plays a crucial role in identifying lesions and reducing the risk of blindness. This study proposes a deep learning-based algorithm that analyzes spatial domain features and image quality assessment metrics to perform efficient diabetes screening and detect significant features with low computational cost, achieving high sensitivity and specificity.