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Disrupted Alpha-Ketoglutarate Homeostasis: Understanding Kidney Diseases from the View of Metabolism and Beyond

出版社

DOVE MEDICAL PRESS LTD
DOI: 10.2147/DMSO.S369090

关键词

alpha-ketoglutarate; kidney diseases; metabolism; diabetic nephropathy; acute kidney injury

资金

  1. National Natural Science Foundation of China [82100769]
  2. Science and Technology Planning Project of Zhanjiang City [2021A05064]

向作者/读者索取更多资源

Alpha-ketoglutarate (AKG) is a key intermediate in various metabolic pathways, participating in metabolism and signaling pathways. Kidney diseases are linked to metabolic disorders, and recent research focuses on the protective effects of AKG on healthy aging, which provides potential strategies for developing novel therapies.
Alpha-ketoglutarate (AKG) is a key intermediate of various metabolic pathways including tricarboxylic acid (TCA) cycle, anabolic and catabolic reactions of amino acids, and collagen biosynthesis. Meanwhile, AKG also participates in multiple signaling pathways related to cellular redox regulation, epigenetic processes, and inflammation response. Emerging evidence has shown that kidney diseases like diabetic nephropathy and renal ischemia/reperfusion injury are associated with metabolic disorders. In consistence with metabolic role of AKG, further metabolomics study demonstrated a dysregulated AKG level in kidney diseases. Intriguingly, earlier studies during the years of 1980s and 1990s indicated that AKG may benefit wound healing and surgery recovery. Recently, interests on AKG are arising again due to its protective roles on healthy ageing, which may shed light on developing novel therapeutic strategies against age-related diseases including renal diseases. This review will summarize the physiological and pathological properties of AKG, as well as the underlying molecular mechanisms, with a special emphasis on kidney diseases.

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